Sex differences and testosterone interfere with the structure of the gut microbiota through the bile acid signaling pathway DOI Creative Commons
Xueqing Duan, You-Qi Nie, Xin Xie

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 18, 2024

Background The gut microbiome has a significant impact on human wellness, contributing to the emergence and progression of range health issues including inflammatory autoimmune conditions, metabolic disorders, cardiovascular problems, psychiatric disorders. Notably, clinical observations have revealed that these illnesses can display differences in incidence presentation between genders. present study aimed evaluate whether composition microbiota is associated with sex-specific elucidate mechanism. Methods 16S-rRNA-sequencing technology, hormone analysis, transplantation, gonadectomy, treatment were employed investigate correlation sex or hormones. Meanwhile, genes proteins involved bile acid signaling pathway analyzed both liver ileum tissues. Results diversity from jejunum feces level hormones serum differed sexes young middle-aged Sprague Dawley (SD) rats. However, no similar phenomenon was found geriatric Interestingly, young, middle-aged, old rats, bacterial Gut replacement also suggested hormones, particularly testosterone (T), influenced mRNA protein (specifically SHP , FXR CYP7A1 ASBT ) exhibited gender-specific differences, T may play role mediating expression this pathway. Conclusion Sex-specific structure are mediated by through pathway, pointing potential targets for disease prevention management techniques indicating levels alter via

Language: Английский

Serum testosterone partially mediates the adverse effects of organophosphate pesticides exposure on growth indicators of children and adolescents DOI

Zhenao Zhang,

Xiaoya Sun,

Jingyi Ren

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 294, P. 118073 - 118073

Published: March 29, 2025

Language: Английский

Citations

0
Associations of pentachlorophenol exposure during pregnancy with maternal and infant reproductive hormones based on a birth cohort DOI

Yitao Huo,

Yanjian Wan, Ying Li

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 932, P. 172723 - 172723

Published: April 25, 2024

Language: Английский

Citations

2
Morbidities and mortality among hospitalized patients with hypopituitarism: Prevalence, causes and management DOI Creative Commons
Fahim Ebrahimi, Lukas Andereggen, Emanuel Christ

et al.

Reviews in Endocrine and Metabolic Disorders, Journal Year: 2024, Volume and Issue: 25(3), P. 599 - 608

Published: May 27, 2024

Abstract Hypopituitarism is a highly heterogeneous multisystem disorder that can have major impact on long-term morbidity and mortality, but even more so during acute medical conditions requiring hospitalization. Recent studies suggest significant in-hospital burden with prolonged length of stay, increased rate intensive care unit (ICU) admission, initiation mechanical ventilation − all which may lead to an risk mortality. On the one hand, patients hypopituitarism are often burdened by metabolic complications, including obesity, hypertension, dyslipidemia, hyperglycemia, alone, or in combination, known significantly alter relevant physiological mechanisms, metabolism, innate adaptive immune responses, coagulation, wound healing, thereby contributing adverse outcomes. other depending extent number pituitary hormone deficiencies, early recognition deficiencies appropriate management replacement strategy within well-organized multidisciplinary team stronger determinants short-term outcomes hospitalization this vulnerable patient population. This review aims provide up-to-date summary recent advances pathophysiologic understanding, clinical implications, recommendations for optimized hospitalized hypopituitarism.

Language: Английский

Citations

1
Evolution of biosynthetic human insulin and its analogues for diabetes management DOI

Dileep Francis,

Aksa Mariyam Chacko,

Anagha Anoop

et al.

Advances in protein chemistry and structural biology, Journal Year: 2024, Volume and Issue: unknown, P. 191 - 256

Published: Jan. 1, 2024

Language: Английский

Citations

1
Sex differences and testosterone interfere with the structure of the gut microbiota through the bile acid signaling pathway DOI Creative Commons
Xueqing Duan, You-Qi Nie, Xin Xie

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 18, 2024

Background The gut microbiome has a significant impact on human wellness, contributing to the emergence and progression of range health issues including inflammatory autoimmune conditions, metabolic disorders, cardiovascular problems, psychiatric disorders. Notably, clinical observations have revealed that these illnesses can display differences in incidence presentation between genders. present study aimed evaluate whether composition microbiota is associated with sex-specific elucidate mechanism. Methods 16S-rRNA-sequencing technology, hormone analysis, transplantation, gonadectomy, treatment were employed investigate correlation sex or hormones. Meanwhile, genes proteins involved bile acid signaling pathway analyzed both liver ileum tissues. Results diversity from jejunum feces level hormones serum differed sexes young middle-aged Sprague Dawley (SD) rats. However, no similar phenomenon was found geriatric Interestingly, young, middle-aged, old rats, bacterial Gut replacement also suggested hormones, particularly testosterone (T), influenced mRNA protein (specifically SHP , FXR CYP7A1 ASBT ) exhibited gender-specific differences, T may play role mediating expression this pathway. Conclusion Sex-specific structure are mediated by through pathway, pointing potential targets for disease prevention management techniques indicating levels alter via

Language: Английский

Citations

0