International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(23), P. 13196 - 13196
Published: Dec. 8, 2024
Diabetic
retinopathy
(DR)
is
a
leading
cause
of
blindness.
The
pathogenesis
diabetic
multifactorial
and
incompletely
understood.
Accordingly,
treatment
options
are
limited.
Recent
data
suggest
that
dopamine
might
play
role
in
the
development
progression
DR.
In
present
review,
we
discuss
these
comment
on
potential
modulation
management
this
devastating
microvascular
complication
diabetes
mellitus.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(5), P. 1055 - 1055
Published: May 10, 2024
Cardiovascular
diseases
remain
the
leading
cause
of
death
worldwide,
with
ischemic
heart
disease
(IHD)
as
most
common.
Ischemia-induced
angiogenesis
is
a
process
in
which
vascular
endothelial
growth
factor
(VEGF)
plays
crucial
role.
To
conduct
research
field
VEGF’s
association
cardiovascular
diseases,
it
vital
to
understand
its
role
physiological
and
pathological
processes
heart.
VEGF-based
therapies
have
demonstrated
promising
preclinical
studies.
However,
their
potential
human
currently
under
discussion.
Furthermore,
VEGF
considered
biomarker
for
collateral
circulation
assessment
failure
(HF)
mortality.
Additionally,
involved
angiogenesis,
there
need
elucidate
impact
VEGF-targeted
terms
side
effects.
Journal of Clinical Medicine,
Journal Year:
2025,
Volume and Issue:
14(3), P. 683 - 683
Published: Jan. 21, 2025
This
narrative
review
focuses
on
innovative
treatment
approaches
to
diabetic
retinopathy
meet
the
urgent
demand
for
advancements
in
managing
both
early
and
late
stages
of
disease.
Recent
studies
highlight
potential
adipose
stem
cells
their
secreted
factors
mitigating
retinal
complications
diabetes,
with
promising
results
improving
visual
acuity
reducing
inflammation
angiogenesis
retinopathy.
However,
caution
is
warranted
regarding
safety
long-term
therapeutic
effects
transplantation.
Bone
marrow
mesenchymal
can
also
mitigate
damage
Studies
demonstrate
that
bone
cells-derived
exosomes
suppress
Wnt/β-catenin
pathway,
oxidative
stress,
inflammation,
retina,
offering
promise
future
treatments.
Nanotechnology
has
ability
precisely
target
retina
minimize
systemic
side
effects.
Nanoparticles
nanocarriers
offer
improved
bioavailability,
sustained
release
therapeutics,
synergistic
They
be
a
new
way
effective
prevention
Activation
modulation
PPARα
as
means
been
widely
investigated
recent
years
demonstrated
clinical
trials.
activation
turned
out
method
treating
dyslipidemia,
insulin
sensitivity.
The
combination
modulators
small
molecules
offers
an
interesting
perspective
diseases’
therapy.
Life,
Journal Year:
2025,
Volume and Issue:
15(2), P. 263 - 263
Published: Feb. 9, 2025
Diabetic
retinopathy
(DR),
a
leading
cause
of
vision
impairment
worldwide,
is
characterized
by
progressive
damage
to
the
retina
due
prolonged
hyperglycemia.
Despite
advances
in
treatment,
current
interventions
largely
target
late-stage
vascular
complications,
leaving
underlying
neurodegenerative
processes
insufficiently
addressed.
This
article
explores
crucial
role
neuronal
survival,
axonal
growth,
and
synaptic
plasticity
neuroprotective
potential
Brain-Derived
Neurotrophic
Factor
(BDNF)
as
therapeutic
strategy
for
enhancing
retinal
resilience
DR.
Furthermore,
it
discusses
innovative
delivery
methods
BDNF,
such
gene
therapy
nanocarriers,
which
may
overcome
challenges
achieving
sustained
targeted
levels
retina,
focusing
on
early
intervention
preserve
function
prevent
loss.
Medicina,
Journal Year:
2025,
Volume and Issue:
61(1), P. 157 - 157
Published: Jan. 18, 2025
Background
and
Objectives:
Diabetic
retinopathy
(DR)
is
a
common
diabetes
complication
leading
cause
of
blindness.
Although
bariatric
surgery
(BS)
well
studied
for
management,
its
effects
on
DR
onset
progression,
particularly
long-term
outcomes,
remain
underexplored.
This
review
seeks
to
evaluate
the
short-
retinal
outcomes
BS
in
diabetic
patients.
Materials
Methods:
A
systematic
search
PubMed,
Web
Science,
Cochrane
Library
was
conducted
following
PRISMA
2020
guidelines,
including
use
checklist
flow
diagram.
The
included
English-language
articles
(2014–2024)
using
keywords
like
“diabetic
retinopathy”
“bariatric
surgery”.
excluded
studies
published
languages
other
than
English,
as
reviews,
case
reports,
those
lacking
adequate
data
or
relevance.
risk
bias
determined
by
Downs
Black
checklist.
literature
conducted,
results
were
organized
displayed
tables
summarize
compare
main
findings.
Results:
After
screening
158
articles,
13
involving
17,903
patients
selected,
focusing
progression
regression.
Short-term
suggest
that
may
stabilize
improve
but
poses
risks
worsening
advanced
cases,
requiring
careful
monitoring.
However,
findings
are
inconsistent,
with
evidence
both
regression
progression.
These
variations
highlight
need
further
research.
Discussion:
generally
improves
effect
depends
preoperative
severity
glycemic
control.
Further
should
explore
additional
factors
better
predict
post-surgery.
Conclusions:
weight
blood
pressure,
control,
potentially
benefiting
DR.
uncertain
due
conflicting
Rapid
changes
after
pose
Large-scale,
longitudinal
needed
clarify
role
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 8, 2025
Abstract
In
recent
years,
nanomaterials
have
demonstrated
broad
prospects
in
the
diagnosis
and
treatment
of
retinal
diseases
due
to
their
unique
physicochemical
properties,
such
as
small‐size
effects,
high
biocompatibility,
functional
surfaces.
Retinal
are
often
accompanied
by
complex
pathological
microenvironments,
where
conventional
diagnostic
therapeutic
approaches
face
challenges
low
drug
delivery
efficiency,
risks
associated
with
invasive
procedures,
difficulties
real‐time
monitoring.
Nanomaterials
hold
promise
addressing
these
limitations
traditional
therapies,
thereby
improving
precision
efficacy.
The
applications
diagnostics
summarized,
they
enable
high‐resolution
imaging
carrying
fluorescent
probes
or
contrast
agents
act
biosensors
sensitively
detect
disease‐related
biomarkers,
facilitating
early
dynamic
therapeutics,
functionalized
nanocarriers
can
precisely
deliver
drugs,
genes,
antioxidant
molecules
target
cells,
significantly
enhancing
outcomes
while
reducing
systemic
toxicity.
Additionally,
nanofiber
materials
possess
properties
that
make
them
particularly
suitable
for
regeneration
tissue
engineering.
By
loading
neurotrophic
factors
into
scaffolds,
regenerative
effects
be
amplified,
promoting
repair
neurons.
Despite
immense
potential,
clinical
translation
still
requires
long‐term
biosafety,
scalable
manufacturing
processes,
optimization
targeting
efficiency.
Discover Nano,
Journal Year:
2025,
Volume and Issue:
20(1)
Published: May 3, 2025
Ocular
drug
delivery
is
a
significant
challenge
due
to
the
intricate
anatomy
of
eye
and
various
physiological
barriers.
Conventional
therapeutic
approaches,
while
effective
some
extent,
often
fall
short
in
effectively
targeting
ocular
diseases,
resulting
suboptimal
outcomes
factors
such
as
poor
bioavailability,
frequent
dosing
requirements,
systemic
side
effects,
limited
penetration
through
This
review
elucidates
eye's
physiology,
prevalent
traditional
modalities,
inherent
pharmacokinetic
pharmacodynamic
limitations
associated
with
these
modalities.
Subsequently,
it
delves
into
nanotechnology-based
solutions,
presenting
breakthroughs
nanoformulations
nanocrystals,
liposomes,
dendrimers,
nanoemulsions
that
have
demonstrated
enhanced
stability,
controlled
release,
deeper
penetration.
Additionally,
explores
range
nanosized
carriers,
including
nano-structured
lipid
hydrogels,
nanogels,
nanoenzymes,
microparticles,
conjugates,
exosomes,
nanosuspensions,
viral
vectors,
polymeric
nanoparticles,
their
applications.
Unique
insights
include
emerging
innovations
nanowafers
transcorneal
iontophoresis,
which
indicate
paradigm
shifts
non-invasive
delivery.
Furthermore,
sheds
light
on
advantages
platforms
addressing
challenges
Though
nano-based
systems
are
drawing
increasing
attention
potential
enhance
bioavailability
efficacy,
ends
up
emphasizing
imperative
need
for
further
research
drive
innovation
improve
patient
ophthalmology.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(9), P. 2053 - 2053
Published: Sept. 10, 2024
Diabetic
retinopathy
(DR)
is
a
leading
cause
of
blindness,
yet
its
molecular
mechanisms
are
unclear.
Extracellular
vesicles
(EVs)
contribute
to
dysfunction
in
DR,
but
the
characteristics
and
functions
vitreous
EVs
This
study
investigated
inflammatory
properties
type
2
diabetic
(db)
EVs.
isolated
from
db
non-db
donors
were
used
for
nanoparticle
tracking
analysis
(NTA),
transmission
electron
microscopy
(TEM),
immunogold
staining,
Western
blotting,
proteomic
by
mass
spectrometry.
Intracellular
uptake
differentiated
macrophages
was
evaluated
using
ExoGlow
membrane
labeling,
impact
on
macrophage
(THP-1)
activation
assessed
cytokine
levels
RT-qPCR.
NTA
TEM
showed
non-aggregated
with
heterogeneous
size
range
below
200
nm.
blot
detected
EV
markers
(Alix,
Annexin
V,
HSP70,
Flotillin
1)
an
upregulation
Cldn5
While
incorporated
into
macrophages,
treatment
THP-1
cells
significantly
increased
mRNA
TNFα
IL-1β
compared
Proteomic
gene
enrichment
indicated
pro-inflammatory
Our
results
suggest
potential
involvement
EC-derived
Cldn5+
triggering
inflammation,
offering
novel
mechanism
involved
presenting
possible
therapeutic
avenue
DR.
