The Polygenic Hazard Score Mediates the Association between Plasma Neurofilament Light Chain and Brain Morphometry in dementia spectrum DOI

Hamide Nasiri,

Mohammad Hossein Azaraein,

Shayan Shakeri

et al.

Archives of Gerontology and Geriatrics, Journal Year: 2024, Volume and Issue: 130, P. 105703 - 105703

Published: Nov. 25, 2024

Language: Английский

Dietary patterns and blood-based biomarkers of Alzheimer's disease in cognitively intact older adults: Findings from a population-based study DOI Creative Commons
Aleš Mrhar, Adrián Carballo‐Casla, Giulia Grande

et al.

The Journal of Prevention of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown, P. 100124 - 100124

Published: March 1, 2025

Diet can impact cognitive aging, but comprehensive data from human studies is lacking and the underlying biological mechanisms are still not fully understood. To investigate associations between two dietary patterns consistently linked to inflammation brain health [the Mediterranean diet (MDS) inflammatory potential of (EDII)] five blood-based biomarkers Alzheimer´s disease (AD) in a sample dementia-free community-dwelling older adults. We used cross-sectional Swedish National Study on Aging Care Kungsholmen (SNAC-K). Participants who were institutionalized, had dementia or Parkinson's disease, missing and/or excluded. Our study consisted 1907 adults ≥60 years old. Adherence MDS EDII was assessed using validated food frequency questionnaire. T-tau, p-tau181, Aβ 42/40, NfL, GFAP measured serum. Associations estimated through quantile regression models at 25th, 50th, 75th percentiles biomarkers' levels, adjusted for confounders stratified by sex, age, APOE-e4 genotype. In whole sample, higher adherence associated with lower levels p-tau181 50th [β (95% CI) per 1-SD increment = -0.028 (-0.053, -0.002) -0.036 (-0.072, -0.001), respectively], while NfL percentile =0.031 (0.008, 0.053)]. other only apparent their distribution. Subgroup analyses showed: 1) stronger inverse association carriers than non-carriers, 2) an participants ≥78 years. seems be AD pathology cognitively intact Some more presence genetic predisposition advanced age.

Language: Английский

Citations

0
Plasma GFAP, NfL, and p-tau181 levels as early biomarkers of dementia in Chinese adults: Shenzhen community cohort study DOI Creative Commons

Chunhua Liang,

Xueqin Yan,

Jing Tian

et al.

Aging Clinical and Experimental Research, Journal Year: 2025, Volume and Issue: 37(1)

Published: March 26, 2025

Language: Английский

Citations

0
The association between rs6859 in NECTIN2 gene and Alzheimer’s disease is partly mediated by pTau DOI Creative Commons
Aravind Lathika Rajendrakumar, Konstantin G. Arbeev,

Olivia Bagley

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Aug. 6, 2024

Emerging evidence suggests a connection between vulnerability to infections and Alzheimer's disease (AD). The nectin cell adhesion molecule 2

Language: Английский

Citations

3
Deformability of Heterogeneous Red Blood Cells in Aging and Related Pathologies DOI Creative Commons
Dmitry S. Prudinnik,

Aigul Kussanova,

Ivan A. Vorobjev

et al.

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2024

Aging is interrelated with changes in red blood cell parameters and functionality. In this article, we focus on cells (RBCs) provide a review of the known associated characterization RBC deformability aging related pathologies. The biophysical complement commonly used biochemical may contribute to better understanding process. power measurement approach well established clinical settings. Measuring RBCs' has advantage relative simplicity, it reflects complex effects developing erythrocytes during aging. However, pathological conditions also promote heterogeneity features have certain impact variance erythrocyte properties. possible applications as an early biomarker states are discussed, modulating PIEZO1 therapeutic target suggested. shape can serve proxy for evaluation, leveraging single-cell analysis imaging flow cytometry artificial intelligence algorithms. RBCs progress humans will dynamics

Language: Английский

Citations

1
Pathologic and clinical correlates of region-specific brain GFAP in Alzheimer’s disease DOI Creative Commons
Jared Phillips, Rebecca L. Winfree,

Mabel Seto

et al.

Acta Neuropathologica, Journal Year: 2024, Volume and Issue: 148(1)

Published: Nov. 24, 2024

Abstract Plasma glial fibrillary acidic protein (GFAP) is an emerging biomarker of Alzheimer’s disease (AD), with higher blood GFAP levels linked to faster cognitive decline, particularly among individuals high brain amyloid burden. However, few studies have examined expression clarify if peripheral associations reflect changes. This study aimed correlate region-specific mRNA ( n = 917) and abundance (n=386) diverse neuropathological measures at autopsy in the Religious Orders Study Rush Memory Aging Project (ROS/MAP) characterize interaction between burden on downstream outcomes. We assessed gene dorsolateral prefrontal cortex, caudate nucleus, posterior cingulate cortex respect core AD pathology (amyloid-β tau), cerebrovascular (microinfarcts, macroinfarcts, cerebral angiopathy [CAA]), proteinopathic (TDP-43, Lewy bodies), These were further level using tandem-mass tag proteomic measurements from cortex. also interactions neuropathology Cortical significantly upregulated participants a neuropathologically confirmed diagnosis (all P FDR < 3.5e−4), but not positive for tau negative > 0.05). Higher cortical associated increased pathology, CAA decline 3.3e−3). GFAP’s phosphorylated cognition influenced by burden, being most pronounced amyloid-positive individuals, confirming previous vivo observations. No observed outcomes nucleus. Our results support findings suggest that are individuals.

Language: Английский

Citations

1
The association between rs6859 in NECTIN2 gene and Alzheimers disease is partly mediated by pTau DOI Creative Commons
Aravind Lathika Rajendrakumar, Konstantin G. Arbeev,

Olivia Bagley

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 22, 2024

Emerging evidence suggests a connection between vulnerability to infections and Alzheimer's disease (AD). The nectin cell adhesion molecule 2

Language: Английский

Citations

0
Plasma GFAP, NfL, and p-tau181 levels as early biomarkers of dementia in Chinese adults: Shenzhen community cohort study DOI Creative Commons

Chunhua Liang,

Xueqing Yan, Jing Tian

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 30, 2024

Abstract Background Although blood-based biomarkers can be used to detect early Alzheimer’s disease (AD), population differences affect their clinical value in diagnosis of the spectrum. Aims To examine potential plasma different stages along AD continuum a Chinese Methods We enrolled 113 adults from Shenzhen community (53 cognitively unimpaired [CU], 45 with mild cognitive impairment [MCI], and 15 AD). single-molecule array technique levels glial fibrillary acidic protein (GFAP), neurofilament light (NfL), phosphorylated-tau181 (p-tau181), performed APOE genotyping. assessed association between scores, receiver operating characteristic curves measure performance for diagnosis. Results The GFAP, NfL, p-tau181 increased significantly were slightly higher MCI than CU (GFAP p = 0.811, NfL 0.909, 0.696). GFAP negatively correlated scores. Blood markers demonstrated identifying or MCI. Plasma displayed highest diagnostic AD. Predictions more robust when blood combined indicators (age, sex, body mass index, years education, APOE ε4 carrier status). Discussion expression continuum. Importantly, could identify individuals general population, superior predictive age sex. Conclusions are useful screening adults.

Language: Английский

Citations

0
The Polygenic Hazard Score Mediates the Association between Plasma Neurofilament Light Chain and Brain Morphometry in dementia spectrum DOI

Hamide Nasiri,

Mohammad Hossein Azaraein,

Shayan Shakeri

et al.

Archives of Gerontology and Geriatrics, Journal Year: 2024, Volume and Issue: 130, P. 105703 - 105703

Published: Nov. 25, 2024

Language: Английский

Citations

0