Current Advances in the Therapeutic Potential of Scutellarin: Novel Applications, Mechanisms, and Future Challenges.

Phytomedicine Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100754 - 100754

Published: Jan. 1, 2025

Language: Английский

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A Recent Review On: Effect of Nutrients On Brain Function and Development

Indus journal of bioscience research., Journal Year: 2025, Volume and Issue: 3(1), P. 125 - 135

Published: Jan. 16, 2025

Recent studies have demonstrated the important role that nutrition plays in maintaining cognitive health by highlighting substantial effects of different nutrients on brain growth and function. Research articles from Google scholar, scihub, PUBMED was searched for food development Important are connected to neurodevelopment, synaptic plasticity, general function include omega-3 fatty acids, B vitamins, antioxidants, vital minerals. The structure depend especially DHA, neurotransmitter production resilience supported vitamins. Vitamins E C examples antioxidants reduce oxidative stress support neurons. Cognitive deficits linked mineral shortages, those involving iron zinc. This review summarizes research relationship between long-term problems nutritional deficiencies, particularly during developmental stages. Additionally, diets high particular better mental outcomes lowers risks various illnesses caused neurodegeneration. Overall, this highlights how crucial a balanced diet is promoting throughout life.

Language: Английский

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Editorial: Vitamin D and mineral ion homeostasis: endocrine dysregulation in chronic diseases

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 21, 2025

This 'Research Topic' is intended to bring together experts share their experiences in explaining the roles and regulations of vitamin D mineral ions various chronic human diseases. A total 15 articles by 102 authors have been published this accomplish objectives. Seven those detail functional aspects D, two explain kidney stone-related complications, another discuss parathyroid pathology, remaining elaborate ion dysregulation disease pathologies. Micronutrients, including trace elements, work optimize biological biochemical functions body. Essential components such as calcium, phosphate, zinc, iron, selenium magnesium, well vitamins, play crucial maintaining metabolic balance within Delicate interactions these nutrients are vital for physiological functioning systems organs. Vitamin has a U-shaped effect on both inflammation calcium-phosphate metabolism. was recently demonstrated 25(OH)D 1,25(OH)2D large cross-sectional study (5). Consequently, it not surprising that supplementation does benefit everyone. Clear benefits from observed patients with deficiency (6,7). However, who already adequate levels usually do additional supplementation. highlights need status assessment (CKD) avoid under-and over- long-term hypoparathyroidism resulting thyroidectomy comorbidities subjects without following thyroidectomy. Those noted greater risk suffering disease, cardiovascular nephrolithiasis. lower incident fractures. Disease may be due hypercalciuria formation calcium phosphate deposits deposition renal tubules.Hypocalcemia PTH at vascular cardiac lead complications (10). On other hand, hypercalcemia hypocalciuria also result symptoms fatigue, weakness, increased coronary heart chondrocalcinosis, pancreatitis, femoral fractures (11). Magnesium inadequacy can disrupt regulation hormone (PTH) which turn affects RANK/RANKL/OPG signaling pathway. results osteoclastic activity, contributing bone loss development osteoporosis (14). Studies indicate magnesium increase density prevent further loss; neuroprotective effects cognitive decline reported (15). Therefore, represents an easy cost-effective strategy delay progression osteoporosis, particularly elderly individuals (16).liver (NAFLD) stone formation. Although they no significant link between two, proposed mechanisms oxidative stress, insulin resistance, lipotoxicity, could contribute NAFLD. Additionally, elevated blood lipid hyperuricemia. Zhiyi et al. adiposity markers correlated Lipid parameters strongly predict hyperuricemia, especially women.Elevated triglycerides metabolism disorders impair function, reducing uric acid excretion causing Knowing serum metabolic, cardiovascular, autoimmune, disorders.Both venous capillary used testing (17) potassium intake, levels, survival hemodialysis patients, dietary restrictions. They plant-based foods high potassium, potatoes melons, contain carbohydrates plasma through release. Animal-based but low carbohydrates, leading levels.In occurs primarily feces (18). Meat consumption worsen uremia cause constipation nitridecontaining products, whereas diet help reduce uremic toxins fiber intake (19). The concluded there little direct association patients.They recommended considerations should focus only content type food its overall nutrient profile.The Research Topic highlighted clinical minerals vitamins balance.Minerals health, proper depends nutrients. Additional research into diseases related needed gain deeper understanding conditions associated (20)(21)(22)(23)(24).Additionally, identifying populations deficiencies encouraging diets rich potentially onset will open new avenues preventive medicine. Finally, topic provides valuable insights while highlighting areas where more fully understand complex relationships health.

Language: Английский

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Magnesium and Migraine

Nutrients, Journal Year: 2025, Volume and Issue: 17(4), P. 725 - 725

Published: Feb. 18, 2025

Migraine is a widespread and intricate neurological condition that involves various factors marked by recurring headache episodes. among the ten conditions accounting for greatest disability in whole population, leading cause of children adolescents aged 5–19 years, second adults 20–59 years. Magnesium deficiency also very common resulting from diverse reasons, including insufficient dietary consumption or increased loss through gastrointestinal renal system. Accumulated evidence case reports, case–control studies, observational randomized, placebo-controlled trials has shown effectiveness magnesium supplementation alleviating migraine, both acutely chronically. Mechanisms may help explain these results include potential link between deficit spreading cortical depression, vascular changes, oxidative stress, chronic inflammation, nervous excitation, neurotransmitter release, electrolyte imbalances. This article aims to provide comprehensive review available on links considering role pathogenesis migraine utility its prevention treatment.

Language: Английский

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Dietary magnesium intake affects the association between dietary vitamin A and depression: a cross-sectional study

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 1, 2025

Depression represents a significant global health burden, ranking as one of the leading causes disability worldwide, and nutrition plays key role in mental health. Vitamin A, essential for immune neurological function, has shown conflicting associations with depression. Magnesium, neurotransmission neuroprotection, is associated reduced risk Importantly, magnesium required activation enzymes involved vitamin A metabolism, suggesting potential interaction between these nutrients However, this remains poorly understood. This study investigates how intake modifies relationship depression, aim elucidating their combined effects informing personalized dietary strategies depression prevention. Data were extracted from National Health Nutrition Examination Survey (NHANES) conducted 2005 2016, involving total 60,936 participants. The final analysis included 25,277 adults aged ≥20 years (Female: 12,581, Male:12,696), excluding pregnant women, individuals under 20, those incomplete data. was assessed using Patient Questionnaire-9 (PHQ-9), supplemented by self-reporting questionnaires. Dietary via recall interview at mobile examination center (MEC). intake, treated continuous variable, categorized based on median value. Stratified analyses sex levels low: <310 mg/day; high: ≥310 Male: <400 ≥400 mg/day). Our cross-sectional showed that women low higher (OR: 0.83, 95% CI: 0.76-0.92, p < 0.001), whereas no association observed high group. Men did not show such an interaction. There also reducing incidence (p-value = 0.145). suggests sex-specific modulating risk. highlights nutritional interventions management. Further randomized controlled trials are warranted to confirm findings.

Language: Английский

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The role of magnesium in pancreatic beta-cell function and homeostasis

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Sept. 25, 2024

Magnesium plays an essential role in glucose utilization and insulin signaling. Recent advances have revealed a greater prevalence of hypomagnesemia general, low intracellular magnesium levels individuals with diabetes contribute to β-cell dysfunction resistance. This article describes the documented effects on various aspects β-cells homeostasis. Studies demonstrated that deficiency is associated reduced pancreatic activity increased resistance patients type 2 diabetes. Additionally, involved many cellular events, including energy homeostasis, protein synthesis, DNA stability. Furthermore, critical for proper signaling, can lead dysregulation ATP-sensitive potassium (KATP) channels β-cells, impairing secretion. Therefore, maintaining adequate crucial overall health preventing metabolic disorders such as

Language: Английский

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Effects and mechanisms of APP and its cleavage product Aβ in the comorbidity of sarcopenia and Alzheimer’s disease

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Nov. 25, 2024

Sarcopenia and AD are both classic degenerative diseases, there is growing epidemiological evidence of their comorbidity with aging; however, the mechanisms underlying biology commonality have not yet been thoroughly investigated. APP a membrane protein that expressed in tissues only nervous system but also NMJ muscle. Deposition its proteolytic cleavage product, Aβ, has described as central component pathogenesis. Recent studies shown excessive accumulation aberrant expression muscle lead to pathological lesions, pathogenic mechanism by which products act skeletal less well understood. By summarizing analyzing literature concerning role, pathogenicity muscles, we aimed explore intrinsic myocerebral comorbidities provide new perspectives theoretical foundations for prevention treatment sarcopenia comorbidities.

Language: Английский

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