Editorial: Vitamin D and mineral ion homeostasis: endocrine dysregulation in chronic diseases DOI Creative Commons
Rahnuma Ahmad,

Bara Sarraj,

Mohammed S. Razzaque

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 21, 2025

This 'Research Topic' is intended to bring together experts share their experiences in explaining the roles and regulations of vitamin D mineral ions various chronic human diseases. A total 15 articles by 102 authors have been published this accomplish objectives. Seven those detail functional aspects D, two explain kidney stone-related complications, another discuss parathyroid pathology, remaining elaborate ion dysregulation disease pathologies. Micronutrients, including trace elements, work optimize biological biochemical functions body. Essential components such as calcium, phosphate, zinc, iron, selenium magnesium, well vitamins, play crucial maintaining metabolic balance within Delicate interactions these nutrients are vital for physiological functioning systems organs. Vitamin has a U-shaped effect on both inflammation calcium-phosphate metabolism. was recently demonstrated 25(OH)D 1,25(OH)2D large cross-sectional study (5). Consequently, it not surprising that supplementation does benefit everyone. Clear benefits from observed patients with deficiency (6,7). However, who already adequate levels usually do additional supplementation. highlights need status assessment (CKD) avoid under-and over- long-term hypoparathyroidism resulting thyroidectomy comorbidities subjects without following thyroidectomy. Those noted greater risk suffering disease, cardiovascular nephrolithiasis. lower incident fractures. Disease may be due hypercalciuria formation calcium phosphate deposits deposition renal tubules.Hypocalcemia PTH at vascular cardiac lead complications (10). On other hand, hypercalcemia hypocalciuria also result symptoms fatigue, weakness, increased coronary heart chondrocalcinosis, pancreatitis, femoral fractures (11). Magnesium inadequacy can disrupt regulation hormone (PTH) which turn affects RANK/RANKL/OPG signaling pathway. results osteoclastic activity, contributing bone loss development osteoporosis (14). Studies indicate magnesium increase density prevent further loss; neuroprotective effects cognitive decline reported (15). Therefore, represents an easy cost-effective strategy delay progression osteoporosis, particularly elderly individuals (16).liver (NAFLD) stone formation. Although they no significant link between two, proposed mechanisms oxidative stress, insulin resistance, lipotoxicity, could contribute NAFLD. Additionally, elevated blood lipid hyperuricemia. Zhiyi et al. adiposity markers correlated Lipid parameters strongly predict hyperuricemia, especially women.Elevated triglycerides metabolism disorders impair function, reducing uric acid excretion causing Knowing serum metabolic, cardiovascular, autoimmune, disorders.Both venous capillary used testing (17) potassium intake, levels, survival hemodialysis patients, dietary restrictions. They plant-based foods high potassium, potatoes melons, contain carbohydrates plasma through release. Animal-based but low carbohydrates, leading levels.In occurs primarily feces (18). Meat consumption worsen uremia cause constipation nitridecontaining products, whereas diet help reduce uremic toxins fiber intake (19). The concluded there little direct association patients.They recommended considerations should focus only content type food its overall nutrient profile.The Research Topic highlighted clinical minerals vitamins balance.Minerals health, proper depends nutrients. Additional research into diseases related needed gain deeper understanding conditions associated (20)(21)(22)(23)(24).Additionally, identifying populations deficiencies encouraging diets rich potentially onset will open new avenues preventive medicine. Finally, topic provides valuable insights while highlighting areas where more fully understand complex relationships health.

Language: Английский

Neuroprotective effects of magnesium: implications for neuroinflammation and cognitive decline DOI Creative Commons

Veer Patel,

Nuraly Akimbekov, William B. Grant

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 25, 2024

Neurodegenerative diseases, which are characterized by progressive neuronal loss and cognitive decline, a significant concern for the aging population. Neuroinflammation, shared characteristic of these is implicated in their pathogenesis. This article briefly summarizes role magnesium, an essential mineral involved numerous enzymatic reactions critical bioactivity, context neuroinflammation decline. The potential neuroprotective effects including mechanisms neuroprotection magnesium through maintaining ion homeostasis, reducing inflammation, preventing excitotoxicity, also described. Additionally, we discuss impact inadequate on its as therapeutic agent attenuating decline to improve neurodegenerative conditions.

Language: Английский

Citations

7
Pre-Type 1 Diabetes in Adolescents and Teens: Screening, Nutritional Interventions, Beta-Cell Preservation, and Psychosocial Impacts DOI Open Access

Brody Sundheim,

Krish Hirani,

M Blaschke

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(2), P. 383 - 383

Published: Jan. 9, 2025

Type 1 Diabetes (T1D) is a progressive autoimmune disease often identified in childhood or adolescence, with early stages detectable through pre-diabetic markers such as autoantibodies and subclinical beta-cell dysfunction. The identification of the pre-T1D stage critical for preventing complications, diabetic ketoacidosis, enabling timely interventions that may alter progression. This review examines multifaceted approach to managing T1D risk adolescents teens, emphasizing detection, nutritional interventions, preservation strategies, psychosocial support. Screening T1D-associated offers predictive insight into risk, particularly when combined education family resources promote lifestyle adjustments. Although alone are not capable T1D, certain weight management specific choices, have shown potential preserve insulin sensitivity, reduce inflammation, mitigate metabolic strain. Pharmacological including immune-modulating drugs like teplizumab, alongside emerging regenerative cell-based therapies, offer delay onset by protecting function. social psychological impacts diagnosis also significant, affecting adolescents' quality life, dynamics, mental health. Supportive counseling, cognitive-behavioral therapy (CBT), group support, recommended emotional burden pre-diabetes. Future directions call integrating universal targeted screening programs within schools primary care, advancing research nutrition promoting policies enhance access preventive resources. Advocacy insurance coverage screening, health services crucial support families risk. By addressing these areas, healthcare systems can intervention, improve preservation, overall well-being at T1D.

Language: Английский

Citations

0
Editorial: Vitamin D and mineral ion homeostasis: endocrine dysregulation in chronic diseases DOI Creative Commons
Rahnuma Ahmad,

Bara Sarraj,

Mohammed S. Razzaque

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 21, 2025

This 'Research Topic' is intended to bring together experts share their experiences in explaining the roles and regulations of vitamin D mineral ions various chronic human diseases. A total 15 articles by 102 authors have been published this accomplish objectives. Seven those detail functional aspects D, two explain kidney stone-related complications, another discuss parathyroid pathology, remaining elaborate ion dysregulation disease pathologies. Micronutrients, including trace elements, work optimize biological biochemical functions body. Essential components such as calcium, phosphate, zinc, iron, selenium magnesium, well vitamins, play crucial maintaining metabolic balance within Delicate interactions these nutrients are vital for physiological functioning systems organs. Vitamin has a U-shaped effect on both inflammation calcium-phosphate metabolism. was recently demonstrated 25(OH)D 1,25(OH)2D large cross-sectional study (5). Consequently, it not surprising that supplementation does benefit everyone. Clear benefits from observed patients with deficiency (6,7). However, who already adequate levels usually do additional supplementation. highlights need status assessment (CKD) avoid under-and over- long-term hypoparathyroidism resulting thyroidectomy comorbidities subjects without following thyroidectomy. Those noted greater risk suffering disease, cardiovascular nephrolithiasis. lower incident fractures. Disease may be due hypercalciuria formation calcium phosphate deposits deposition renal tubules.Hypocalcemia PTH at vascular cardiac lead complications (10). On other hand, hypercalcemia hypocalciuria also result symptoms fatigue, weakness, increased coronary heart chondrocalcinosis, pancreatitis, femoral fractures (11). Magnesium inadequacy can disrupt regulation hormone (PTH) which turn affects RANK/RANKL/OPG signaling pathway. results osteoclastic activity, contributing bone loss development osteoporosis (14). Studies indicate magnesium increase density prevent further loss; neuroprotective effects cognitive decline reported (15). Therefore, represents an easy cost-effective strategy delay progression osteoporosis, particularly elderly individuals (16).liver (NAFLD) stone formation. Although they no significant link between two, proposed mechanisms oxidative stress, insulin resistance, lipotoxicity, could contribute NAFLD. Additionally, elevated blood lipid hyperuricemia. Zhiyi et al. adiposity markers correlated Lipid parameters strongly predict hyperuricemia, especially women.Elevated triglycerides metabolism disorders impair function, reducing uric acid excretion causing Knowing serum metabolic, cardiovascular, autoimmune, disorders.Both venous capillary used testing (17) potassium intake, levels, survival hemodialysis patients, dietary restrictions. They plant-based foods high potassium, potatoes melons, contain carbohydrates plasma through release. Animal-based but low carbohydrates, leading levels.In occurs primarily feces (18). Meat consumption worsen uremia cause constipation nitridecontaining products, whereas diet help reduce uremic toxins fiber intake (19). The concluded there little direct association patients.They recommended considerations should focus only content type food its overall nutrient profile.The Research Topic highlighted clinical minerals vitamins balance.Minerals health, proper depends nutrients. Additional research into diseases related needed gain deeper understanding conditions associated (20)(21)(22)(23)(24).Additionally, identifying populations deficiencies encouraging diets rich potentially onset will open new avenues preventive medicine. Finally, topic provides valuable insights while highlighting areas where more fully understand complex relationships health.

Language: Английский

Citations

0