Does diabetes modify the triglyceride–glucose index associated with cardiovascular events and mortality? A meta-analysis of 50 cohorts involving 7,239,790 participants

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 27, 2025

Abstract Introduction Previous studies highlighted the association between triglyceride–glucose (TyG) index and cardiovascular events in patients with diabetes. However, whether diabetes affects TyG-cardiovascular diseases (CVD) is still unclear. This study aimed to evaluate TyG CVD risk, stratified by status, as well potential modifying effect of diabetic status. Methods/design The PubMed, Cochrane Library, Embase databases were searched for on associations mortality without from inception December 2, 2024. random effects model was employed pool sizes. Results A total 50 cohort (7,239,790 participants) included. mean age participants 31.46 years (diabetes mellitus [DM]: 65.18; non-DM: 31.23), 40.66% female (DM: 36.07%; 40.70%). (HR: 1.72 vs. 1.55, P = 0.55), major adverse cerebrovascular 2.02 1.91, 0.84), stroke 1.46 1.39, 0.77) death 1.85 1.60, 0.56) similar among DM non-DM individuals. ischemic heart disease (IHD) 2.20 1.57, 0.03) all-cause 1.94 1.24, 0.01) stronger than patients. Conclusion showed events, mortality, independent low moderate certainty. IHD individuals Future should explore role index-associated outcomes mortality. Graphical abstract

Language: Английский

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The association of triglyceride-glucose index and combined obesity indicators with chest pain and risk of cardiovascular disease in American population with pre-diabetes or diabetes

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 6, 2024

To investigate the correlation of triglyceride-glucose (TyG) index and its combined obesity indicators with chest pain cardiovascular disease (CVD) in pre-diabetes diabetes population.

Language: Английский

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Association between triglyceride-glucose index and its combination with obesity indicators and depression: findings from NHANES 2005–2020

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: March 10, 2025

Background The relationship between the triglyceride-glucose (TyG) index, its combination with obesity indicators, and depression remains understudied in American population. Methods This cross-sectional study analyzed data from 10,423 adults National Health Nutrition Examination Survey (NHANES) conducted 2005 2020. We employed multivariable logistic regression analysis, smoothing techniques, generalized additive models, stratified analyses, sensitivity analyses to examine TyG, (TyG-WC, TyG-WHtR, TyG-BMI) depression. Results results indicate that TyG TyG-WC, TyG-BMI, exhibited a significant statistical association depressive symptoms (all P for trend < 0.001). Specifically, one-unit increase index correlated 37% risk of (95% CI: 1.21–1.55), TyG-WC 3.26 times 2.22–4.80), TyG-WHtR 27% 1.18–1.36), TyG-BMI 2.30 1.72–3.08). There was nonlinear correlation nonlinearity 0.001), except linear (P linearity Conclusion Monitoring may facilitate assessment prevention.

Language: Английский

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The Impact of the Triglyceride-Glucose Index on the Development of Depression in Patients with Coronary Atherosclerotic Heart Disease

Neuropsychiatric Disease and Treatment, Journal Year: 2024, Volume and Issue: Volume 20, P. 2105 - 2113

Published: Nov. 1, 2024

Depression is common among patients with coronary atherosclerotic heart disease and a prevalent mental health issue, particularly those cardiovascular diseases. commonly associated elevated blood glucose lipid levels. The triglyceride-glucose index novel indicator reflecting insulin resistance, which has been proven in numerous studies to be

Language: Английский

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