Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15
Published: Dec. 10, 2024
The association between the triglyceride-glucose (TyG) index and mortality in general population remains controversial, with inconsistent findings across studies.
Language: Английский
Diabetology & Metabolic Syndrome, Journal Year: 2025, Volume and Issue: 17(1)
Published: Feb. 15, 2025
The significant burden of cardiovascular diseases underscores the necessity for identifying novel predictive markers that can forecast both and mortality. In recent years, TyG-obesity-related parameters have gained special attention in this regard. This study aimed to assess association between TyG-waist circumference (TyG-WC) A comprehensive search was performed databases including PubMed, Scopus, Web Science from their inception until October 6, 2024. key outcomes interest included all-cause mortality, diseases, myocardial infarction, stroke, coronary artery peripheral heart failure. pooled risk ratio (RR) with corresponding 95% confidence intervals (CI) calculated. Meta-analysis carried out using StataMP 14.0. total 17 studies were analysis. number participants ranged 2,224 95,342. meta-analysis revealed TyG-WC is significantly associated an increased diseases. However, only one addressed relationship failure a positive correlation. indicates could serve as promising predictor along Given its accessibility, may be practical tool screening purposes.
Language: Английский
Citations
1
Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)
Published: Feb. 28, 2025
Cardiovascular-kidney-metabolic (CKM) syndrome has been recently proposed by American Heart Association recently. The triglyceride glucose (TyG) index and TyG-related indices combined with obesity indicators have proven to be associated the incidence of cardiovascular diseases (CVD). However, there are few studies explore whether these associations exist among people CKM stages 0–3. A total 7,364 participants from China Health Retirement Longitudinal Study were included. Cox hazard regression restricted cubic spline used analyze CVD incidence. To compare predictive performance, time-dependent Harrell's C-indices, net reclassification integrated discrimination improvement conducted. was 20.55% over nine years. TyG single all modified capable predicting RCS analyses showed that had linear relationships waist circumference (TyG-WC) or waist-to-height ratio (TyG-WHtR) still existed in stage 1, 2 3. TyG-WC (C-index: 0.621, p < 0.001) TyG-WHtR almost highest C-indices incidence, compared 0.611, body mass 0.616, 0.001). independent predictors It found better especially ratio.
Language: Английский
Citations
1
Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16
Published: Jan. 31, 2025
The association between triglyceride-glucose (TYG) and its composite obesity indexes cardio-renal disease in the American population remains insufficiently researched. This study examined a cohort of 11,491 adults aged 20 years older from 2003-2018 National Health Nutrition Examination Survey (NHANES). To explore associations TYG, TyG-Waist-to-Height Ratio (TyG-WHtR), TyG-Body Mass Index (TyG-BMI), TyG-Waist Circumference (TyG-WC), chronic kidney (CKD), cardiovascular (CVD), cardiorenal syndrome (CRS), we utilized weighted multivariate logistic regression, restricted cubic spline (RCS), Receiver operating characteristic (ROC), subgroup analyses. Adjusted for confounding factors, there are positive likelihood CKD, CVD, CRS, as well TYG indexes. index was correlated most strongly with CKD (OR 1.42, 95% CI 1.11, 1.82; P = 0.007), while TyG-WHtR had strongest correlations CVD 1.63, 1.19, 2.22; 0.003) CRS 1.44, 1.00, 2.08; 0.055). A nonlinear connection found by RCS analysis (P overall < 0.001, 0.05), predominantly linear > 0.05). Based on ROC curves, TyG-WC emerged more reliable diagnostic tools than cardiac renal diseases. According to analyses, TyG measurements were associated younger individuals (≤ 50), males, those diabetes mellitus interaction an increased risk disease, indicating enhanced accuracy. These metrics provide effective tool identifying early improving stratification.
Language: Английский
Citations
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Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: 375, P. 390 - 396
Published: Jan. 20, 2025
Language: Английский
Citations
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World Journal of Diabetes, Journal Year: 2025, Volume and Issue: 16(3)
Published: Jan. 20, 2025
BACKGROUND Recent studies have indicated that triglyceride glucose (TyG)-waist height ratio (WHtR) and TyG-waist circumference (TyG-WC) are effective indicators for evaluating insulin resistance. However, research on the association in TyG-WHtR, TyG-WC, risk prognosis of major adverse cardiovascular events (MACEs) type 2 diabetes mellitus (T2DM) cases limited. AIM To clarify relation MACEs overall mortality T2DM patients. METHODS Information this investigation was obtained from Action to Control Cardiovascular Risk Diabetes (ACCORD)/ACCORD Follow-On (ACCORDION) study database. The Cox regression model applied assess among TyG-WC future cases. RCS analysis utilized explore nonlinear correlation. Subgroup interaction analyses were conducted prove robustness. receiver operating characteristic curves additional predicting value TyG-WHtR TyG-WC. RESULTS After full adjustment confounding variables, highest baseline cohort respectively exhibited a 1.353-fold 1.420-fold higher mortality, than lowest quartile group. Similarly, showed 1.314-fold 1.480-fold respectively. Each 1 SD increase significantly related an 11.7% 14.9% enhance mortality. corresponded 11.5% 16.6% Including these two indexes conventional models improved predictive power CONCLUSION promising predictors
Language: Английский
Citations
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Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16
Published: Jan. 22, 2025
Aims Research on the triglyceride-glucose (TyG) index in patients with stable coronary artery disease (SCAD) remains relatively limited. Therefore, this study aims to investigate association of TyG and its derived indicators, including baseline index, triglyceride glucose-body mass (TyG-BMI), mean glucose index-standard deviation (TyG-SD), prognosis SCAD undergoing percutaneous intervention (PCI). Methods This retrospective enrolled 2,306 patients. The Cox proportional hazards model was utilized evaluate between four indicators major adverse cardiovascular cerebrovascular events (MACCE). predictive ability for MACCE assessed using time-dependent receiver operating characteristic (ROC) curve. Kaplan-Meier survival analysis employed assess prognostic differences among groups. Results After a median follow-up 26.1 months, total 352 (15.3%) experienced MACCE. regression revealed that under fully adjusted model, when were stratified by tertiles, highest tertile each indicator had significantly increased risk compared those lowest tertile. Specifically, hazard ratio 1.653 (95% confidence intervals (CI): 1.234-2.214), TyG-BMI 2.467 (95%CI: 1.849-3.293), 2.451 1.794-3.349), TyG-SD 1.896 1.430-2.513). Time-dependent ROC curve demonstrated strongest at time point. results showed grouped there significant cumulative incidence three groups (P < 0.05). Conclusion Higher levels independently positively associated PCI. Among these greatest value Consequently, tracking long-term trends may be prioritized clinical practice.
Language: Английский
Citations
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BMC Medical Informatics and Decision Making, Journal Year: 2025, Volume and Issue: 25(1)
Published: Feb. 3, 2025
Language: Английский
Citations
0
Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)
Published: March 7, 2025
The incidence of heart failure (HF), a cardiovascular disease, has been widely reported to be gradually increasing. Although the triglyceride-glucose (TyG) index is associated with risk HF, this relationship may affected by differences in nutritional status among individuals varying levels obesity. Waist circumference combined TyG more accurately HF. This study analyzed data from 8769 participants 2011–2020 National Health and Nutrition Examination Survey (NHANES). After weighting data, multivariable logistic regressions were used calculate associations between HF TyG-waist (TyG-WC) indices adults different body mass (BMIs). Restricted cubic splines employed assess for linear or nonlinear relationships. Receiver operating characteristic (ROC) curves demonstrate efficacy models indices. Net Reclassification Index (NRI) was measure improvement TyG-WC relative models. Integrated Discriminant Improvement (IDI) supports conclusion. positively (TyG: odds ratio [OR], 1.765; 95% CI], 1.390–2.242; P < 0.001; TyG-WC: OR, 1.003; CI, 1.002–1.004; 0.001), except In Model 4 (OR, 1.238; 0.941–1.629; = 0.124). BMI categorize population into normal underweight overweight obese groups. groups, (OR) increased as value increased. However, high low ORs. According ROC, NRI, IDI analyses, weight groups (area under curve [AUC]: 0.6724; CI: 0.4991-0.6400), whereas alone not (AUC: 0.5695; 0.6115–0.7334). 4, adjusted all covariates, had slightly better ability than (NRI: -0.4112; -0.6818- -0.1406; 0.05; IDI: -0.0072; 95%CI: -0.0228-0.0083; 0.36256). populations, 0.3089; 0.1726–0.4451; 0.0084; 0.0017–0.0151; 0.05). sensitivity only 41.8%. association these two influenced BMI. normal-weight higher imply improved status. Therefore, should WC both can HF; however, less sensitive when alone.
Language: Английский
Citations
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Immunology, Journal Year: 2025, Volume and Issue: unknown
Published: March 24, 2025
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality globally. Recent groundbreaking preclinical clinical research underscores the pivotal role metabolite remodelling in pathology CVD. This metabolic transformation not only directly fuels progression CVD but also profoundly influences immune response within cardiovascular system. In this review, we focused on complex interactions between alterations responses during course Furthermore, explore potential therapeutic interventions that could be developed based understanding dysregulation By targeting these immunological pathways, novel strategies for prevention treatment CVDs might to improve patient outcomes reduce global burden disease.
Language: Английский
Citations
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Acta Diabetologica, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0