A systematic review on gut microbiota in type 2 diabetes mellitus

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 17, 2025

The gut microbiota play crucial roles in the digestion and degradation of nutrients, synthesis biological agents, development immune system, maintenance gastrointestinal integrity. Gut dysbiosis is thought to be associated with type 2 diabetes mellitus (T2DM), one world's fastest growing diseases. aim this systematic review identify differences composition diversity individuals T2DM. A search was conducted studies reporting on difference between T2DM healthy controls. Relevant were evaluated, their characteristics results extracted using a standardized data extraction form. assessed for risk bias findings reported narratively. 58 observational published 2010 2024 included. Beta commonly different individuals. Genera Lactobacillus, Escherichia-Shigella, Enterococcus, Subdoligranulum Fusobacteria found positively associated; while Akkermansia, Bifidobacterium, Bacteroides, Roseburia, Faecalibacteirum Prevotella negatively This demonstrates strong association dysbiosis, as evidenced by differential microbial abundances altered indices. Among these taxa, Escherichia-Shigella consistently T2DM, whereas Faecalibacterium prausnitzii appears offer protective effect against However, heterogeneity nature preclude establishment causative relationships. Future research should incorporate age, diet medication-matched controls, include functional analysis microbes. https://www.crd.york.ac.uk/prospero/, identifier CRD42023459937.

Language: Английский

Global bibliometric analysis of traditional Chinese medicine regulating gut microbiota in the treatment of diabetes from 2004 to 2024

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 23, 2025

Objectives The therapeutic efficacy of Traditional Chinese Medicine (TCM) in modulating gut microbiota for diabetes treatment has garnered increasing scholarly attention. This study aims to meticulously examine current research trajectories and focal areas from 2004 2024, providing a foundational framework future inquiries. Methods A comprehensive search documents published between 2024 was conducted using the Web Science database. resulting data were analyzed visualized R software, VOSviewer, CiteSpace. Results included total 751 documents. From 2022, number annual publications showed continuous upward trend (2004: n = 1 2022: 159), 2023 (n 141) decreased slightly previous year. China emerged as leading country terms article 430). Additionally, United States played prominent role international collaborations. Frontiers Pharmacology 31) most frequently journal, while Nature 1,147) achieved highest citation count. Key identified keywords obesity, insulin resistance, inflammation, oxidative stress. Conclusion Three key focuses this domain include: effects active constituents TCM on via modulation, underlying mechanisms through which influences management, targeted regulation specific bacterial populations by diabetes.

Language: Английский

Diphenyl diselenide protects against diabetic kidney disease through modulating gut microbiota dysbiosis in streptozotocin-induced diabetic rats

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 3, 2024

Diphenyl diselenide (DPDS) ameliorates nephropathy in streptozotocin (STZ)-induced type 1 diabetic rats by inhibiting oxidative stress and inflammatory reactions. However, it has not been clarified whether DPDS alleviates kidney disease (DKD) is related to the inhibition of extracellular matrix (ECM) production regulation intestinal flora disorder.

Language: Английский