Bioactivity, Molecular Mechanism, and Targeted Delivery of Flavonoids for Bone Loss

Nutrients, Journal Year: 2023, Volume and Issue: 15(4), P. 919 - 919

Published: Feb. 12, 2023

Skeletal disabilities are a prominent burden on the present population with an increasing life span. Advances in osteopathy have provided various medical support for bone-related diseases, including pharmacological and prosthesis interventions. However, therapeutics post-surgery complications often reported due to side effects associated modern-day therapies. Thus, therapies utilizing natural means fewer toxic or other key acceptable Flavonoids constitute class of bioactive compounds found dietary supplements, their attributes been well appreciated. Recently, flavonoids’ role is gaining renowned interest its effect bone remodeling. A wide range flavonoids has play pivotal major signaling pathways, such as wingless-related integration site (Wnt)/β-catenin, morphogenetic protein (BMP)/transforming growth factor (TGF)-β, mitogen-activated kinase (MAPK), etc. reduced bioavailability absorption limitations inhibiting use against complications. Recent utilization nanotechnological approaches delivery methods (biomaterial scaffolds, micelles) target control release can enhance flavonoids. we tried recapitulate understanding regulating mechanisms affecting remodeling utilized therapeutical potential treating loss.

Language: Английский

Screening of superior anti‐osteoporotic flavonoids from Epimedii Folium with dual effects of reversing iron overload and promoting osteogenesis

Biomedical Chromatography, Journal Year: 2023, Volume and Issue: 37(9)

Published: June 5, 2023

Abstract Iron overload is a risk factor for postmenopausal osteoporosis (PMOP) and lowering iron levels to regulate the labile plasma preferred therapy. Icariin (ICA), baohuoside I (BHS) icaritin (ICT) are three flavonoids obtained from Epimedii Folium that efficient in facilitating osteogenesis. In this study, an active flavonoid with dual effects of reversing promoting osteogenesis was screened based on pharmacokinetics, complexation properties potential downregulate overload, PMOP. As result, vivo absorption compounds ICA > ICT BHS, while exposure muscle bone BHS ICA. vitro showed only complexed Fe (III) at 1:1 ratio 3‐OH ICT–Fe complex ( m / z 424.3750) identified by UPLC–Q‐TOF–MS. dynamic detection also concentration complexes varied plasma. The behavioral blunting loss zebrafish induced were significantly reversed dose‐dependent manner. Pharmacokinetic–pharmacodynamic analysis negatively correlated serum ferritin positively osteogenic markers including alkaline phosphatase, osteocalcin osteoprotegerin. Bone ovariectomized rats altered after intervention, reduced improved marker levels. These results demonstrated had favorable musculoskeletal penetration capability shrink iron, showing superior performance anti‐PMOP through

Language: Английский

Exploring the boost of steaming with wine on Ligustri Lucidi Fructus in treating postmenopausal osteoporosis based on superior “multi-component structure” and iron/bone metabolism coregulation

Phytomedicine, Journal Year: 2023, Volume and Issue: 123, P. 155275 - 155275

Published: Dec. 12, 2023

Language: Английский