Nutraceuticals and Functional Foods: A Comprehensive Review of Their Role in Bone Health

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5873 - 5873

Published: May 28, 2024

Bone health is the result of a tightly regulated balance between bone modeling and remodeling, alterations these processes have been observed in several diseases both adult pediatric populations. The imbalance remodeling can ultimately lead to osteoporosis, which most often associated with aging, but contributing factors already act during developmental age, when over third mass accumulated. maintenance an adequate influenced by genetic environmental factors, such as physical activity diet, particularly intake calcium vitamin D. In addition, it has claimed that integration specific nutraceuticals resveratrol, anthocyanins, isoflavones, lycopene, curcumin, lutein, β-carotene bioactive compounds from diet honey, tea, dried plums, blueberry, olive oil be efficient strategies for loss prevention. Nutraceuticals functional foods are largely used provide medical or benefits, there urge determine products clinical evidence strong safety profile. aim this review explore scientific positive role food health, focusing on molecular mechanisms real-world studies.

Language: Английский

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Therapeutic Potential of Quercetin as an Antioxidant for Bone-Muscle-Tendon Regeneration and Aging

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2024

Quercetin (QC), a naturally occurring bioflavonoid found in various fruits and vegetables, possesses many potential health benefits, primarily attributed to its robust antioxidant properties. The generation of oxidative stress bone cells is key modulator their physiological behavior. Moreover, status influences the pathophysiology mineralized tissues. Increasing scientific evidence demonstrates that manipulating redox balance might be an effective technique for developing disease therapies. QC abilities skeletal muscle significantly enhance regeneration reduce atrophy. In addition, has been shown have protective effects against stress, inflammation, apoptosis, matrix degradation tendons, helping maintain structural integrity functionality tendons. Thus, properties crucial addressing age-related musculoskeletal disorders like osteoporosis, sarcopenia, tendon-related inflammatory conditions. Understanding how signaling pathways involved disorders, including effect on bone, muscle, tendon differentiation, provide insights into diverse advantages promoting tissue preventing cellular damage. Therefore, this study reviewed intricate relationship among repair, affected by antioxidative QC, tissues improve overall bones, muscles, tendons system. Also, reviewing ongoing clinical trials systems encouraging. Given positive health, further investigations controlled human intervention studies are necessary explore therapeutic optimum strength.

Language: Английский

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Effects of Roselle (Hibiscus sabdariffa Linn.) flower extracts on various inflammatory and bone apposition biomarkers during orthodontic tooth movement: An experimental animal study

Journal of Oral Biology and Craniofacial Research, Journal Year: 2025, Volume and Issue: 15(2), P. 412 - 420

Published: Feb. 22, 2025

Language: Английский

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Nano formulation of Sophora japonica extract stimulates osteogenic activity in osteoblasts

Journal of Food Science and Technology, Journal Year: 2025, Volume and Issue: unknown

Published: April 12, 2025

Language: Английский

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Comparison of dose and time effects of flavonoids, alone or in combination, on the induction of mineralization markers in human osteoblast-like cells

Archives of Oral Biology, Journal Year: 2025, Volume and Issue: 175, P. 106285 - 106285

Published: May 5, 2025

Language: Английский

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Liposome-Mediated Delivery Improves the Efficacy of Lisosan G against Retinopathy in Diabetic Mice

Cells, Journal Year: 2023, Volume and Issue: 12(20), P. 2448 - 2448

Published: Oct. 13, 2023

Nutraceuticals are natural substances whose anti-oxidant and anti-inflammatory properties may be used to treat retinal pathologies. Their efficacy is limited by poor bioavailability, which could improved using nanocarriers. Lisosan G (LG), a fermented powder from whole grains, protects the retina diabetic retinopathy (DR)-induced damage. For this study, we tested whether encapsulation of LG in liposomes (LipoLG) increase its protective effects. Diabetes was induced mice via streptozotocin administration, were allowed freely drink water or dispersion two different doses LipoLG. Electroretinographic recordings after 6 weeks showed that only highest dose partially protect diabetes-induced functional deficits, while both LipoLG effective. An evaluation molecular markers oxidative stress, inflammation, apoptosis, vascular endothelial growth factor, blood-retinal barrier confirmed protected DR-induced changes, virtually complete prevention obtained with either These data indicate contrasting DR greatly enhanced lay ground for new dietary supplements therapeutic effects against DR.

Language: Английский

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The Comparative Study of the Administration of the Combination Preparation of Isoflavones and Hyaluronic Acid in Menopausal Women for the Treatment of the Symptoms of Menopause, Urogenital Atrophy and Oteoporosis in Relation to Existing Hormone Replacement Therapies

Materia Socio Medica, Journal Year: 2023, Volume and Issue: 35(3), P. 206 - 206

Published: Jan. 1, 2023

Background: Menopause is characterized by a series of symptoms and effects from the various systems organs, for which, decline in estrogen production ovaries considered responsible. Objective: The aim this study was to make comparative administration combination preparation isoflavones hyaluronic acid menopausal women treatment menopause, urogenital atrophy osteoporosis relation existing hormone replacement therapies. Methods: In five-year, double-blind, placebo-controlled clinical study, total 274 postmenopausal were enrolled classified into three groups. Participants group A, 96 who did not receive Hormone Replacement Therapy (HRT), second group, 92 received daily with tibolone (2.5 mg) as monotherapy, third 86 pharmaceutical formulation 120 mg isoflavones. MF11RCE 80 mg. Results: our significant reduction found both groups B C participants preparations compared A HRT. Furthermore, no difference efficacy observed between administered tibolone. Conclusion: has same symptoms.

Language: Английский

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Novel and potential therapy options for a range of cancer diseases: Using Flavonoid

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: unknown, P. 154997 - 154997

Published: Nov. 1, 2023

Language: Английский

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Insights into Osteogenesis Induced by Crude Brassicaceae Seeds Extracts: A Role for Glucosinolates

Nutrients, Journal Year: 2024, Volume and Issue: 16(20), P. 3457 - 3457

Published: Oct. 12, 2024

Background/Objectives: Crude extracts from the Brassica genus have recently emerged as promising phytochemicals for preventing bone loss. While most documented evidence suggests that their general biological activity is due to glucosinolates’ (GLSs’) hydrolysis products, direct of GLSs beginning be uncovered. However, contribution bone-sparing crude Brassicaceae has seldom been addressed. Here, we aimed gain insights into this gap by studying in same vitro model human osteogenesis effect two seed (Eruca sativa and Lepidium sativum) obtained defatted meals, comparing them isolated represented composition, glucoerucin (GER) glucotropaeolin (GTL), Eruca sativum, respectively. Methods: Osteogenic differentiation mesenchymal stromal cells (hMSCs) was assessed alizarin red staining assay real-time PCR, respectively, evaluating mineral apposition mRNA expression specific osteogenic genes. Results: Both increased differentiation, indicating stimulating can at least partially attributed GLSs. Moreover, these data extend previous unhydrolyzed glucoraphanin (GRA) on other types GLSs: GER GTL. Notably, E. extract GTL induced higher stimulation than sativum GER, Conclusions: Overall, study expands knowledge possible application Brassica-derived bioactive molecules natural alternatives prevention treatment bone-loss pathologies.

Language: Английский

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ANTIOXIDANT PROPERTIES OF OSTEOGENIC APATITE-POLYMER BIOMATERIALS FUNCTIONALIZED WITH PHYTOCOMPOUNDS

Eastern Ukrainian Medical Journal, Journal Year: 2024, Volume and Issue: 12(4), P. 742 - 756

Published: Jan. 1, 2024

Background. Innovative methods of regenerating damaged bone involve the use new materials with incorporated biologically active molecules, stem cells, carbon and metal nanoparticles. Ceramics based on calcium orthophosphates are an alternative to native tissue, their modification nanoparticles (NPs) improve properties functionality composites is a trend in science biomaterials. The known toxic effect NPs human body by provoking oxidative stress through formation reactive oxygen species (ROS), excessive amount which causes DNA damage death surrounding cells requires search for effective antioxidants Materials Methods. study was conducted review literature compounds plant origin, characterized high antioxidant activity osteoconductive properties, biomedical engineering. Results. To accelerate implant osseointegration, it important protect from stress, increases inflammation can lead rejection. antioxidants, namely polyphenolic compounds, biocompatibility biomaterials increase properties. provides data such phytocompounds as extracts medicinal plants (Fructus chebulae, Aloe vera, Camelia sinensis, Salvia officinalis), naringin, quercetin, kaempferol, resveratrol, catechins. By functionalizing biomaterials, appropriate concentration bioactive implantation zone maintained, release controlled, contributes neutralization ROS, proliferation osteogenic differentiation potential, osteoclasts suppressed, various signaling pathways regulated. Conclusions. analysis sources has shown that promising used synthesis innovative biocomposite materials. combination polyphenols improves biocompatibility, osteoconductivity osteoinductivity ability reduce promote tissue regeneration, including bone, makes them biomolecular

Language: Английский

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