Genetic Insights into Breast Cancer in Northeastern Mexico: Unveiling Gene–Environment Interactions and Their Links to Obesity and Metabolic Diseases DOI Open Access
Hugo L. Gallardo‐Blanco, María Lourdes Garza-Rodríguez, Diana Cristina Pérez-Ibave

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(6), P. 982 - 982

Published: March 14, 2025

Background: Breast cancer (BC), one of the most common cancers, has increased in Mexico during past decade, along with other chronic and metabolic diseases. Methods: Herein, we analyzed 121 SNPs (85 related to BC and/or glucose-associated pathways 36 SNP classified as ancestry markers) 92 confirmed cases 126 unaffected women from Northeastern Mexico. The relationship these BC, considering BMI, menopause status, age cofactors, was explored using a gene–environment (G × E) interaction multi-locus model. Results: Twelve gene variants were significantly associated BC: three located exome (rs3856806 PPARG, rs12792229 MMP8, rs5218 KCNJ11-ABCC8), nine non-coding regions, which are involved accelerated decay mRNA transcripts, regulatory flanking regions (rs3917542 PON1; rs3750804 rs3750805 TCF7L2; rs1121980 rs3751812 FTO; rs12946618 RPTOR; rs2833483 SCAF4; rs11652805 AMZ2P1-GNA13; rs1800955 SCT-DEAF1-DRD4). Conclusions: This study identified an association between menopause, (above 45), obesity, overweight status implicated diabetes mellitus, insulin resistance, inflammation, remodeling extracellular matrix.

Language: Английский

The Proteins of mRNA Modification: Writers, Readers, and Erasers DOI Creative Commons
Mathieu N. Flamand, Matthew Tegowski, Kate D. Meyer

et al.

Annual Review of Biochemistry, Journal Year: 2023, Volume and Issue: 92(1), P. 145 - 173

Published: April 17, 2023

Over the past decade, mRNA modifications have emerged as important regulators of gene expression control in cells. Fueled large part by development tools for detecting RNA transcriptome wide, researchers uncovered a diverse epitranscriptome that serves an additional layer regulation beyond simple sequence. Here, we review proteins write, read, and erase these marks, with particular focus on most abundant internal modification, N6-methyladenosine (m6A). We first describe discovery key enzymes deposit remove m6A other discuss how our understanding has shaped views modification dynamics. then current models function reader knowledge evolved. Finally, highlight future directions field questions remain unanswered.

Language: Английский

Citations

91
The promise of new anti-obesity therapies arising from knowledge of genetic obesity traits DOI Open Access
Anke Hinney, Antje Körner, Pamela Fischer‐Posovszky

et al.

Nature Reviews Endocrinology, Journal Year: 2022, Volume and Issue: 18(10), P. 623 - 637

Published: July 28, 2022

Language: Английский

Citations

78
Obesity, Bone Loss, and Periodontitis: The Interlink DOI Creative Commons
Pengfei Zhao, Aimin Xu, WK Leung

et al.

Biomolecules, Journal Year: 2022, Volume and Issue: 12(7), P. 865 - 865

Published: June 22, 2022

Obesity and periodontitis are both common health concerns that have given rise to considerable economic societal burden worldwide. There established negative relationships between bone metabolism obesity, obesity diabetes mellitus (DM), DM periodontitis, name a few, with osteoporosis being considered long-term complication of obesity. In the oral cavity, metabolic disorders primarily display as increased risks for alveolar loss. Obesity-driven loss mandibular been observed in animal models without inoculation periodontopathogens. Clinical reports also indicated possible association periodontitis. This review systematically summarizes clinical periodontium changes, including obese individuals. Relevant laboratory-based focusing on biological interlinks obesity-associated remodeling via processes like hyperinflammation, immune dysregulation, microbial dysbiosis, were reviewed. We discuss potential mechanism underlying obesity-enhanced from systemic periodontal perspectives, delineating practical considerations managing disease patients.

Language: Английский

Citations

64
The Role of Cow’s Milk Consumption in Breast Cancer Initiation and Progression DOI Creative Commons
Bodo C. Melnik, Swen Malte John, Pedro Carrera‐Bastos

et al.

Current Nutrition Reports, Journal Year: 2023, Volume and Issue: 12(1), P. 122 - 140

Published: Feb. 2, 2023

Abstract Purpose of Review This review evaluates cow milk’s impact on breast carcinogenesis by linking recent epidemiological evidence and new insights into the molecular signaling milk its constituents in cancer (BCa) pathogenesis. Recent Findings prospective cohort studies support association between cow’s consumption risk estrogen receptor- α -positive (ER + ) BCa. Milk is a complex biological fluid that increases systemic insulin-like growth factor 1 (IGF-1), insulin signaling, interacting hormonal promoters Further potential oncogenic components commercial include exosomal microRNAs (miR-148a-3p, miR-21-5p), bovine meat factors, aflatoxin M1, bisphenol A, pesticides, micro- nanoplastics. Individuals with BRCA1 loss-of-function mutations FTO IGF1 gain-of-function polymorphisms enhancing IGF-1/mTORC1 may be at increased for milk-induced ER Summary pathobiochemical identify as critical Large meta-analyses gathering individuals different ethnic origins derived from dairy cows varying genetic backgrounds diverse feeding procedures well missing data thermal processing (pasteurization versus ultra-heat treatment) make multi-national unsuitable BCa estimations susceptible populations. Future are required consider all vulnerable periods to exposure, beginning during perinatal period puberty, since these most mammary gland morphogenesis. Notwithstanding need better including detailed information human carcinogenesis, available suggests dietary guidelines have reconsidered.

Language: Английский

Citations

23
Unraveling Adipose Tissue Dysfunction: Molecular Mechanisms, Novel Biomarkers, and Therapeutic Targets for Liver Fat Deposition DOI Creative Commons
Marta Lopez‐Yus,

C. Hörndler,

Sofía Borlán

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(5), P. 380 - 380

Published: Feb. 22, 2024

Adipose tissue (AT), once considered a mere fat storage organ, is now recognized as dynamic and complex entity crucial for regulating human physiology, including metabolic processes, energy balance, immune responses. It comprises mainly two types: white adipose (WAT) brown (BAT) thermogenesis, with beige adipocytes demonstrating the plasticity of these cells. WAT, beyond lipid storage, involved in various activities, notably lipogenesis lipolysis, critical maintaining homeostasis. also functions an endocrine secreting adipokines that influence metabolic, inflammatory, processes. However, dysfunction especially related to obesity, leads disturbances, inability properly store excess lipids, resulting ectopic deposition organs like liver, contributing non-alcoholic fatty liver disease (NAFLD). This narrative review delves into multifaceted roles its composition, functions, pathophysiology WAT dysfunction. explores diagnostic approaches adipose-related disorders, emphasizing importance accurately assessing AT distribution understanding relationships between compartments health. Furthermore, it discusses therapeutic strategies, innovative therapeutics adipose-derived mesenchymal stem cells (ADMSCs)-based treatments gene therapy, highlighting potential precision medicine targeting obesity associated complications.

Language: Английский

Citations

14
RNA methylation‐related inhibitors: Biological basis and therapeutic potential for cancer therapy DOI Creative Commons

Huanxiang Chen,

Hongyang Liu,

Chenxing Zhang

et al.

Clinical and Translational Medicine, Journal Year: 2024, Volume and Issue: 14(4)

Published: April 1, 2024

Abstract RNA methylation is widespread in nature. Abnormal expression of proteins associated with strongly a number human diseases including cancer. Increasing evidence suggests that targeting holds promise for cancer treatment. This review specifically describes several common modifications, such as the relatively well‐studied N6‐methyladenosine, well 5‐methylcytosine and pseudouridine (Ψ). The regulatory factors involved these modifications their roles are also comprehensively discussed. We summarise diverse functions across different types RNAs. Furthermore, we elucidate structural characteristics along development specific inhibitors them. Additionally, recent advancements small molecule presented to underscore immense potential clinical significance enhancing therapeutic efficacy against Key Points In this paper, important related systematically summarised. Several modification were progression, relationships cell migration, invasion, drug resistance immune environment regulators have been proposed studies summarised detail, which great treatment future.

Language: Английский

Citations

9
Therapeutic Potential of FTO Demethylase in Metabolism and Disease Pathways DOI

Chaitanya Sree Somala,

S. Sathyapriya,

Nagaraj Bharathkumar

et al.

The Protein Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 9, 2025

Language: Английский

Citations

1
Protective Effect of Semaglutide on Obesity-Induced Renal Disease and Obesity-Induced Kidney Renal Clear Cell Carcinoma DOI Creative Commons
Shuqi Wang, Mengmeng Zhang, Xiaoman Yang

et al.

Diabetes Metabolic Syndrome and Obesity, Journal Year: 2025, Volume and Issue: Volume 18, P. 805 - 818

Published: March 1, 2025

Proteomics was used to study the effect of semaglutide on expression renal protein in obese mice, and looking for proteins that could improve prognosis Kidney Renal Clear Cell Carcinoma (KIRC). Thirty-six mice were randomly divided into normal-fat diet group (NFD), high-fat (HFD), plus intervention (HS). Collected serum, urine, kidney tissue samples, detected urinary protein/creatinine, blood glucose, lipid, inflammation, oxidative stress other related indicators. Different staining methods analyze pathological changes mice's kidneys. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis total kidneys mice. Finally, bioinformatics technology significantly different expressed (DEPs). The mechanism protecting phosphorylation, PPAR signaling pathway, thiamine, butyric acid tryptophan metabolism pathways. Moreover, increase Man1a1 Ntn4 while high-expression KIRC population had a better overall survival rate. Semaglutide regulate development by up-adjusting Ntn4.

Language: Английский

Citations

1
Cancer and Obesity: An Obesity Medicine Association (OMA) Clinical Practice Statement (CPS) 2022 DOI

Ethan Lazarus,

Harold Bays

Obesity Pillars, Journal Year: 2022, Volume and Issue: 3, P. 100026 - 100026

Published: July 5, 2022

Language: Английский

Citations

35
The multifaceted functions of the Fat mass and Obesity-associated protein (FTO) in normal and cancer cells DOI Creative Commons
Sébastien Relier, Éric Rivals, Alexandre David

et al.

RNA Biology, Journal Year: 2022, Volume and Issue: 19(1), P. 132 - 142

Published: Jan. 22, 2022

The last decade has seen mRNA modification emerge as a new layer of gene expression regulation. Fat mass and obesity-associated protein (FTO) was the first identified eraser N6-methyladenosine (m6A) adducts, most widespread in eukaryotic messenger RNA. This discovery, reversible dynamic RNA modification, aided by recent technological advances spectrometry sequencing led to birth field epitranscriptomics. FTO crystallized much attention epitranscriptomics researchers resulted publication numerous, yet contradictory, studies describing regulatory role central biological processes. These incongruities may be explained wide spectrum substrates sequence preferences: binds multiple species (mRNA, snRNA tRNA) can demethylate internal m6A snRNA, N6,2′-O-dimethyladenosine (m6Am) adjacent cap, N1-methyladenosine (m1A) tRNA. Here, we review current knowledge related function healthy cancer cells. In particular, emphasize divergent role(s) attributed different tissues subcellular molecular contexts.

Language: Английский

Citations

24