Dementia incidence varied by anticancer drugs and molecular targeted therapy in a population-based cohort study DOI Creative Commons
Eun Hye Lee, Danbee Kang, Jin Lee

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 30, 2024

Anticancer drugs may affect the incidence of dementia by modulating common pathophysiology between cancer and dementia. However, there is a paucity research that focused on anticancer with different mechanisms action their associations subtypes Therefore, we aimed to investigate according various groups drugs. From Korea National Health Insurance Service database, our retrospective population-based cohort study enrolled 116,506 patients aged 65 years older who received January 1, 2008 December 31, 2018. The hazard ratio was determined using Cox proportional hazards regression models, comparing each group all other drugs, after adjusting for covariates. Antimetabolites (HR = 0.91; 95% CI 0.84–0.97) molecular targeted therapies 0.60; 0.49–0.74) were associated decreased Alzheimer type (DAT), but not vascular Among therapies, epidermal growth factor receptor inhibitors 0.46–0.79) multikinase 0.49; 0.27–0.89) low DAT only. Our findings highlight potential repurposing prevent

Language: Английский

Causal relationship between Alzheimer’s disease and prostate cancer: a bidirectional Mendelian randomization analysis DOI Creative Commons

Rongkang Li,

Lei Peng,

Dashi Deng

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: March 13, 2024

Background Previous observational researchers have found an inverse bidirectional link between Alzheimer’s disease (AD) and prostate cancer (PCa); yet, the causative nature of this remains unclear. To investigate causal interactions AD PCa, a Mendelian randomization (MR) analysis was conducted. Methods This study comprised two Genome-Wide Association Study (GWAS) summary statistics for (17,008 cases 37,154 controls) PCa (79,148 61,106 in individuals European ancestry. The inverse-variance weighted (IVW) method employed as primary approach, while MR-Egger, median, mode, simple mode served supplementary methods estimating effect. assess pleiotropy, MR-PRESSO global test MR-Egger regression were used. Cochran’s Q adopted to check heterogeneity, MR Steiger leave-one-out performed confirm robustness reliability results. Results association genetically inferred on using IVW (OR = 0.974, 95% CI 0.958-0.991, p 0.003) forward not 1.000, CI: 0.954-1.049, P 0.988) reverse analysis. sensitivity showed that no pleiotropy heterogeneity observed. findings inordinately affected by any instrumental variables. Conclusion results demonstrated absence causality among population, suggested predicted possibility decreased risk patients, significant effect AD.

Language: Английский

Citations

6
Evaluating the Bidirectional Causal Effects of Alzheimer’s Disease Across Multiple Conditions: A Systematic Review and Meta-Analysis of Mendelian Randomization Studies DOI Open Access
Hong Zhu,

Hongchang Ni,

Qiuling Yang

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3589 - 3589

Published: April 10, 2025

This study systematically evaluates and meta-analyzes Mendelian randomization studies on the bidirectional causal relationship between Alzheimer’s disease (AD) systemic diseases. We searched five databases, assessed quality, extracted data. Diseases were classified using ICD-11, meta-analysis was performed with RevMan 5.4. A total of 56 identified genetic links AD susceptibility Notably, proxies for hip osteoarthritis (OR = 0.80; p 0.007) rheumatoid arthritis 0.97; 0.004) inversely associated risk, while gout 1.02; 0.049) showed a positive association. Genetic liability to depression 1.03; 0.001) elevated risk increased delirium 1.32; 0.0005). Cardiovascular traits, including coronary artery 1.07; 0.021) hypertension 4.30; 0.044), causally linked higher risk. Other conditions, such as insomnia, chronic periodontitis, migraine, certain cancers, exhibited significant correlations. Intriguingly, herpes zoster 0.87; 0.005) cataracts 0.96; 0.012) demonstrated inverse associations AD. These findings suggest potential therapeutic targets preventive strategies, emphasizing need address comorbid diseases reduce progression.

Language: Английский

Citations

0
The inverse association between cancer history and incident cognitive impairment: Addressing attrition bias DOI Creative Commons
Michelle Shardell, Alan M. Rathbun, Ann L. Gruber‐Baldini

et al.

Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: 20(11), P. 7902 - 7912

Published: Sept. 26, 2024

Abstract INTRODUCTION Cancer is inversely associated with cognitive impairment. Whether this due to statistical handling of attrition (death and censoring) unknown. METHODS We quantified associations between cancer history incident impairment among Health, Aging, Body Composition Study participants without baseline or stroke ( n = 2604) using multiple competing‐risks models their corresponding estimands: cause‐specific, subdistribution, marginal hazards, plus composite‐outcome (cognitive all‐cause mortality) hazards. All‐cause mortality was also modeled. RESULTS After covariate adjustment (demographics, apolipoprotein E ε4, lifestyle, health conditions), cause‐specific hazard ratios (HRs) were similar each other (≈ 0.84; P values < 0.05). The subdistribution HR 0.764 (95% confidence interval [CI] 0.645–0.906), Cox model 1.149 CI 1.016–1.299). positively (HR 1.813; 95% 1.525–2.156). DISCUSSION Cause‐specific, hazards produced inverse Competing risk answer slightly different questions, estimand choice influenced findings here. Highlights Findings robust competing risks death. All addressed possible informative censoring bias. 16% lower 81% higher hazard.

Language: Английский

Citations

2
Genetic susceptibility association between viral infection and colorectal cancer risk: a two-sample Mendelian randomization analysis DOI Creative Commons
Gen Li, S. Wang,

Jianli Ma

et al.

Infectious Agents and Cancer, Journal Year: 2024, Volume and Issue: 19(1)

Published: Aug. 10, 2024

The genetic susceptibility association between viral infection and the risk of colorectal cancer (CRC) has not been established.

Language: Английский

Citations

1
Dementia incidence varied by anticancer drugs and molecular targeted therapy in a population-based cohort study DOI Creative Commons
Eun Hye Lee, Danbee Kang, Jin Lee

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 30, 2024

Anticancer drugs may affect the incidence of dementia by modulating common pathophysiology between cancer and dementia. However, there is a paucity research that focused on anticancer with different mechanisms action their associations subtypes Therefore, we aimed to investigate according various groups drugs. From Korea National Health Insurance Service database, our retrospective population-based cohort study enrolled 116,506 patients aged 65 years older who received January 1, 2008 December 31, 2018. The hazard ratio was determined using Cox proportional hazards regression models, comparing each group all other drugs, after adjusting for covariates. Antimetabolites (HR = 0.91; 95% CI 0.84–0.97) molecular targeted therapies 0.60; 0.49–0.74) were associated decreased Alzheimer type (DAT), but not vascular Among therapies, epidermal growth factor receptor inhibitors 0.46–0.79) multikinase 0.49; 0.27–0.89) low DAT only. Our findings highlight potential repurposing prevent

Language: Английский

Citations

0