Expression profile of miR-214, miR-204, miR-25, miR-15a, IL-33, and plasma level of Malondialdehyde might serve as potential biomarkers for Alzheimer’s disease DOI Creative Commons

Haydar Sahib Almawashee,

Mohammad Khalaj‐Kondori,

Mohammad Ali Hoseinpour Feizi

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: June 26, 2024

Abstract Alzheimer’s disease (AD) is a late-of-onset neurodegenerative that affects elder people. Despite immense research on deciphering the pathophysiology of AD, precise etiology AD remains still elusive. Deregulations miRNAs play essential roles in pathogenesis and as result, they might be potential biomarkers for development diagnosis. This study was aimed to assess expression miR-214, miR-204, miR-15a, miR-25, investigate their correlations with IL-33, plasma level Malondialdehyde (MDA) Mini-Mental State Examination (MMSE) score patients. Blood samples were obtained from125 participants including 75 patients 50 healthy controls. Plasma leukocytes isolated used subsequent analysis. Results showed MDA significantly higher Besides, miR-15a miR-25 downregulated patients’ group but miR-214 miR-204 expressions upregulated. negative correlation MMSE positive IL-33 expression. We also observed statistically meaningful between expressions. Correlations studied all non-significant. Furthermore, none or correlated scores. ROC curve analysis revealed miRNAs, could differentiate from In conclusion, our results IL33, considered

Language: Английский

Unraveling the role of miRNAs in the diagnosis, progression, and therapeutic intervention of Alzheimer’s disease DOI
Nourhan M. Abdelmaksoud, Al-Aliaa M. Sallam, Ahmed I. Abulsoud

et al.

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 253, P. 155007 - 155007

Published: Dec. 4, 2023

Language: Английский

Citations

23
Alzheimer’s disease and infectious agents: a comprehensive review of pathogenic mechanisms and microRNA roles DOI Creative Commons

Seyyed Sam Mehdi Hosseininasab,

Rasoul Ebrahimi,

Shirin Yaghoobpoor

et al.

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 18

Published: Jan. 7, 2025

Alzheimer's Disease (AD) is the most prevalent type of dementia and characterized by presence senile plaques neurofibrillary tangles. There are various theories concerning causes AD, but connection between viral bacterial infections their potential role in pathogenesis AD has become a fascinating area research for field. Various viruses such as Herpes simplex virus 1 (HSV-1), Epstein-Barr (EBV), Cytomegalovirus (CMV), influenza viruses, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), well bacteria Chlamydia pneumoniae (CP), Helicobacter pylori (HP), Porphyromonas gingivalis (P. gingivalis), Spirochetes eukaryotic unicellular parasites (e.g., Toxoplasma gondii), have been linked to due ability activate immune system, induce inflammation increase oxidative stress, thereby leading cognitive decline AD. In addition, microRNAs (miRNAs) might play crucial mechanisms these pathogens since they utilized target protein-coding genes, allowing evasion, maintaining latency, suppressing cellular signaling molecules. Also, can regulate gene expression human cells. This article provides an overview association infectious agents, with focus on which may be related These findings suggest important areas further explored future studies.

Language: Английский

Citations

1
Micro-RNA profiles of pathology and resilience in posterior cingulate cortex of cognitively intact elders DOI Creative Commons
Christy M. Kelley, Bryan Maloney, John S. Beck

et al.

Brain Communications, Journal Year: 2024, Volume and Issue: 6(2)

Published: Jan. 1, 2024

Abstract The posterior cingulate cortex (PCC) is a key hub of the default mode network underlying autobiographical memory retrieval, which falters early in progression Alzheimer’s disease (AD). We recently performed RNA sequencing post-mortem PCC tissue samples from 26 elderly Rush Religious Orders Study participants who came to autopsy with an ante-mortem diagnosis no cognitive impairment but collectively displayed range Braak I–IV neurofibrillary tangle stages. Notably, cognitively unimpaired subjects displaying high stages may represent resilience AD pathology. Transcriptomic data revealed elevated synaptic and ATP-related gene expression Stages III/IV compared I/II, suggesting these pathways be related resilience. also mined profiles for small non-coding micro-RNAs (miRNAs), regulate mRNA stability underexplored potential mechanism through fine-tuning within complex cellular networks. Twelve miRNAs were identified as differentially expressed between I/II III/IV. However, extent levels all associated subject demographics, neuropsychological test performance and/or neuropathological diagnostic criteria this cohort was not explored. Here, we report that total 667 are significantly (rho > 0.38, P < 0.05) variables. There significant positive correlations miRNA age, perceptual orientation speed. By contrast, higher correlated negatively semantic episodic memory. Higher 15 lower I–II 47 III–IV, additional mechanistic influences Pathway analysis showed enrichment operating lysine degradation fatty acid synthesis metabolism. Finally, demonstrated 12 resilience-related versus predicted mRNAs amyloid processing, tau inflammation. In summary, demonstrate dynamic state wherein differential intact elders. posit relationships inform transcriptional alterations relevant protective (resilience) or pathogenic (pre-clinical prodromal) responses pathogenesis thus therapeutic targets.

Language: Английский

Citations

5
Spatiotemporal Dysregulation of Neuron–Glia Related Genes and Pro-/Anti-Inflammatory miRNAs in the 5xFAD Mouse Model of Alzheimer’s Disease DOI Open Access
M. Di Ianni, Miriam Corraliza-Gómez, Tiago Costa-Coelho

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9475 - 9475

Published: Aug. 31, 2024

Alzheimer's disease (AD), the leading cause of dementia, is a multifactorial influenced by aging, genetics, and environmental factors. miRNAs are crucial regulators gene expression play significant roles in AD onset progression. This exploratory study analyzed levels 28 genes 5 (miR-124-3p, miR-125b-5p, miR-21-5p, miR-146a-5p, miR-155-5p) related to pathology neuroimmune responses using RT-qPCR. Analyses were conducted prefrontal cortex (PFC) hippocampus (HPC)

Language: Английский

Citations

4
DECIPHERING THE ROLE OF miRNAs IN ALZHEIMER'S DISEASE: PREDICTIVE TARGETING AND PATHWAY MODULATION - A SYSTEMATIC REVIEW DOI
Monika Sharma, Pankaj Pal, Sukesh Kumar Gupta

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 101, P. 102483 - 102483

Published: Sept. 3, 2024

Language: Английский

Citations

4
MicroRNAs signatures as potential molecular markers in mild cognitive impairment: a meta-analysis DOI Creative Commons

Natalia Vargas-Rondón,

Yeimy González‐Giraldo, Angela Garcia

et al.

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 15, 2025

Mild cognitive impairment (MCI) is characterized by a decline in functioning without significant interference daily activities. Its high heterogeneity and elevated conversion rate to dementia pose challenges for accurate diagnosis monitoring, highlighting the urgent need identify methodologies focused on early detection intervention of MCI. Due their biological characteristics, microRNAs (miRNAs) are potential candidates as non-invasive molecular markers identification assessment MCI progression. Therefore, this study, we conducted meta-analysis miRNAs commonly deregulated MCI, focusing expression profiles plasma, serum, extracellular vesicle samples. Our analysis identified eight upregulated miRNAs, including hsa-miR-149-3p, four downregulated such Let-7f-5p. Notably, hsa-miR-149-3p emerged central node interaction networks, suggesting its crucial role regulating cellular processes relevant Additionally, pathway revealed enrichment associated with transcriptional regulation neurodegeneration. results underscore circulating open possibility new that enable more monitoring disease Validating Let-7f-5p, along identifying functional specific context essential establish relevance. This work contributes understanding miRNA profile mild using easily accessible samples, which could be useful development various strategies aimed at preventing or delaying individuals risk developing dementia, Alzheimer's disease.

Language: Английский

Citations

0
Harnessing network pharmacology and in silico drug discovery to uncover new targets and therapeutics for Alzheimer's disease DOI
Haitham Al‐Madhagi,

Husam Nassar

Computers in Biology and Medicine, Journal Year: 2025, Volume and Issue: 187, P. 109781 - 109781

Published: Feb. 5, 2025

Language: Английский

Citations

0
Plasma Biomarkers for Cerebral Amyloid Angiopathy and Implications for Amyloid-Related Imaging Abnormalities: A Comprehensive Review DOI Open Access
Mo‐Kyung Sin, Jeffrey L. Dage, Kwangsik Nho

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(4), P. 1070 - 1070

Published: Feb. 7, 2025

Anti-amyloid therapies (AATs) are increasingly being recognized as promising treatment options for Alzheimer’s disease (AD). Amyloid-related imaging abnormalities (ARIAs), small areas of edema and microbleeds in the brain presenting abnormal signals MRIs patients with AD, most common side effects AATs. While ARIAs asymptomatic, they can be associated symptoms like nausea, headache, confusion, gait instability and, less commonly, more serious complications such seizures death. Cerebral amyloid angiopathy (CAA) has been found to a major risk ARIA development. The identification sensitive reliable non-invasive biomarkers CAA an area AD research over years, but approval AATs, this taken on new urgency. This comprehensive review highlights several potential biomarkers, Aβ40, Aβ40/42, phosphorylated-tau217, neurofilament light chain, glial fibrillary acidic protein, secreted phosphoprotein 1, placental growth factor, triggering receptor expressed myeloid cells 2, cluster differentiation 163, proteomics, microRNA. Identifying staging even before its consequences detected via neuroimaging critical allow clinicians judiciously select appropriate candidates stratify monitoring, properly manage therapeutic regimens those experiencing symptomatic ARIAs, optimize achieve best outcomes. Future studies test plasma human beings evaluate predictive values individual markers severity.

Language: Английский

Citations

0
Roles of non-coding RNAs and exosomal non-coding RNAs, particularly microRNAs, long non-coding RNAs, and circular RNAs, in pathogenic mechanisms behind chronic pain: A review DOI
Zhongkai Wang, Peng Jiao

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141945 - 141945

Published: March 1, 2025

Language: Английский

Citations

0
Advanced Biomarkers: Beyond Amyloid and Tau: Emerging Non-Traditional Biomarkers for Alzheimer’s Diagnosis and Progression DOI

Meher Rijwana Afrin,

P. Upadhyaya,

A. Hashim

et al.

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102736 - 102736

Published: March 1, 2025

Language: Английский

Citations

0