The gut microbiota and its role in the development of cardiovascular disease

Expert Review of Cardiovascular Therapy, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12

Published: Feb. 7, 2025

The pathophysiology of cardiovascular diseases encompasses a complex interplay genetic and environmental risk factors. Even if traditional factors are treated to target, there remains residual risk. This manuscript reviews the potential role gut microbiota in development disease, as target. A systematic search was conducted until 30 October 2024 on PubMed (MEDLINE), using MeSH terms [Gut microbiota] + [Dysbiosis] [Cardiovascular] [TMAO] [bile acids] [short-chain fatty acids]. term dysbiosis implies changes equilibrium, with modifications composition functionality series additional factors: reduced diversity uniformity microorganisms; short-chain acid-producing bacteria; increased permeability; release metabolites, such trimethylamine N-oxide, betaine, phenylalanine, tryptophan-kynurenine, phenylacetylglutamine, lipopolysaccharides; secondary bile acid excretion, leading inflammation, oxidative stress, endothelial dysfunction facilitating onset pathological conditions, including obesity, hypertension, diabetes, atherosclerosis, heart failure. Attempts restore balance through different interventions, mainly diet, have been shown positively affect individual components metabolites reduce disease. In addition, probiotics prebiotics potentially useful. Fecal transplantation is promising therapy.

Language: Английский

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Omega-3 fatty acids and the gut microbiome: a new frontier in cardiovascular disease prevention

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1)

Published: Feb. 25, 2025

Language: Английский

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Oxygenation and intestinal perfusion and its association with perturbations of the early life gut microbiota composition of children with congenital heart disease

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 15, 2025

Early life gut microbiota is known to shape the immune system and has a crucial role in homeostasis. Only little about composition dynamics of intestinal infants with congenital heart disease (CHD) potential influencing factors. We evaluated microbial neonates CHD (n = 13) compared healthy controls (HC, n 30). Fecal samples were analyzed by shotgun metagenomics. Different approaches statistical modeling applied assess impact factors on variation species composition. Unsupervised hierarchical clustering was used detect associations distinct clusters tissue oxygenation perfusion parameters, obtained "oxygen see" (O2C) method. Overall, showed an core dominated genera Enterococcus (27%) Staphylococcus (20%). Furthermore, lower abundance Bacteroides (8% vs. 14%), Parabacteroides (1% 3%), Bifidobacterium (4% 12%), Escherichia 23%) observed HCs. patients that born vaginal delivery fraction (15% 21%) (7% 22%) HCs those cesarean section, these not found at all. In CHD, we significant oxygen saturation (SpO2) relative abundances multivariate analysis variance (F[8,2] 24.9, p 0.04). Statistical suggested large proportional shift from genus Streptococcus (50%) conditions low SpO2 towards (61%) high SpO2. identified three compositional clusters, corresponding differed significantly blood flow global perfusion. differences versus are possibly linked levels. Delivery method may affect stability. However, further studies needed effect interventions including probiotics or fecal transplants early perturbations CHD.

Language: Английский

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Indoleacetylglutamine Pathway Is a Potential Biomarker for Cardiovascular Diseases

Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 377 - 377

Published: March 5, 2025

Cardiovascular diseases (CVDs) remain a leading cause of global morbidity and mortality. Metabolomics allows for the identification important biomarkers CVDs, essential early detection risk assessment. This cross-sectional study aimed to identify novel metabolic associated with CVDs using non-targeted metabolomics. We compared profiles 112 patients confirmed diagnosis gender- age-matched healthy controls from Qatar Biobank database. Orthogonal partial least square discriminate analysis linear models were used analyze differences in level metabolites between two groups. report here significant association indoleacetylglutamine pathway cardiovascular diseases, expanding repertoire gut microbiota linked CVDs. Our findings suggest that alterations metabolism, potentially resulting increased production indoleacetate, indoleacetylglutamine, related compounds at expense cardioprotective indolepropionate, may contribute this association. pave way approaches CVD assessment potential therapeutic interventions targeting gut-heart axis.

Language: Английский

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Antibiotic-induced gut dysbiosis: unraveling the gut-heart axis and its impact on cardiovascular health

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: March 17, 2025

Language: Английский

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Impact of probiotics and polyphenols on adults with heart failure: a systematic review and meta-analysis

European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)

Published: April 21, 2025

Heart failure poses a significant health concern globally, and despite advancements in treatment, the search for additional, supportive therapeutic options remains crucial. This systematic review meta-analysis studied impact of probiotics polyphenols on heart biomarkers, focusing potential improvements function inflammation. We analyzed studies published Embase, PubMed Cochrane library from 2012 to 2024, randomized controlled trials. Our findings are drawn 5 probiotics, involving 401 participants, 3 with total 140 participants. The analysis included assessments LVEF, hs-CRP, creatinine NT-proBNP levels intervention control groups. or did not demonstrate changes indicators patients compared placebo. suggested that while concept dietary management is promising, further research necessary validate efficacy as supplementary therapies care, by analyzing more diverse outcomes patient populations.

Language: Английский

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Intestinal Insights: The Gut Microbiome’s Role in Atherosclerotic Disease: A Narrative Review

Microorganisms, Journal Year: 2024, Volume and Issue: 12(11), P. 2341 - 2341

Published: Nov. 16, 2024

Recent advances have highlighted the gut microbiota as a significant contributor to development and progression of atherosclerosis, which is an inflammatory cardiovascular disease (CVD) characterized by plaque buildup within arterial walls. The microbiota, consisting diverse collection microorganisms, impacts host's metabolism, immune responses, lipid processing, all contribute atherosclerosis. This review explores complex mechanisms through dysbiosis promotes atherogenesis. We emphasize potential integrating modulation with traditional care, offering holistic approach managing Important pathways involve translocation microbial components, metabolism metabolites such trimethylamine-N-oxide (TMAO), production short-chain fatty acids (SCFAs) that influence vascular health. Studies reveal distinct profiles in atherosclerosis patients, increased pathogenic bacteria (

Language: Английский

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