Free Radical Biology and Medicine, Journal Year: 2023, Volume and Issue: 195, P. 359 - 370
Published: Jan. 5, 2023
Language: Английский
Allergy, Journal Year: 2022, Volume and Issue: 77(5), P. 1418 - 1449
Published: Feb. 2, 2022
Environmental exposure plays a major role in the development of allergic diseases. The exposome can be classified into internal (e.g., aging, hormones, and metabolic processes), specific external chemical pollutants or lifestyle factors), general broader socioeconomic psychological contexts) domains, all which are interrelated. All factors we exposed to, from moment conception to death, part exposome. Several hundreds thousands new chemicals have been introduced modern life without our having full understanding their toxic health effects ways mitigate these effects. Climate change, air pollution, microplastics, tobacco smoke, changes loss biodiversity, alterations dietary habits, microbiome due modernization, urbanization, globalization constitute surrounding environment Some disrupt epithelial barriers skin mucosal surfaces, disruptions linked last few decades increasing prevalence severity inflammatory diseases such as atopic dermatitis, food allergy, rhinitis, chronic rhinosinusitis, eosinophilic esophagitis, asthma. barrier hypothesis provides mechanistic explanation how explain rapid increase autoimmune In this review, discuss affecting planet's context 'epithelial hypothesis,' including climate emphasize on addition, roles increased fatty acid consumption environmental substances (detergents, airborne pollen, ozone, nanoparticles, tobacco) discussed. Considering emerging data recent studies, suggest stringent governmental regulations, global policy adjustments, patient education, establishment individualized control measures threats decrease disease.
Language: Английский
Citations
250
Molecular Aspects of Medicine, Journal Year: 2021, Volume and Issue: 85, P. 101026 - 101026
Published: Oct. 7, 2021
Language: Английский
Citations
188
Antioxidants, Journal Year: 2022, Volume and Issue: 11(11), P. 2237 - 2237
Published: Nov. 13, 2022
Inflammation of the human lung is mediated in response to different stimuli (e.g., physical, radioactive, infective, pro-allergenic or toxic) such as cigarette smoke and environmental pollutants. They often promote an increase inflammatory activities airways that manifest themselves chronic diseases allergic airway diseases, asthma, bronchitis/chronic obstructive pulmonary disease (COPD) even cancer). Increased levels oxidative stress (OS) reduce antioxidant defenses, affect autophagy/mitophagy processes, regulatory mechanisms cell survival, promoting inflammation lung. In fact, OS potentiate lung, favoring progression diseases. increases production reactive oxygen species (ROS), including superoxide anions (O2-), hydroxyl radicals (OH) hydrogen peroxide (H2O2), by transformation through enzymatic non-enzymatic reactions. this manner, reduces endogenous defenses both nucleated non-nucleated cells. The ROS can derive from exogenous insults (cigarette pollution) sources injury and/or activated structural review, we describe most relevant knowledge concerning functional interrelation between
Language: Английский
Citations
105
Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(5), P. 2166 - 2184
Published: Jan. 26, 2024
Environmental pollutants have been recognized for their ability to induce various adverse outcomes in both the environment and human health, including inflammation, apoptosis, necrosis, pyroptosis, autophagy. Understanding these biological mechanisms has played a crucial role risk assessment management efforts. However, recent identification of ferroptosis as form programmed cell death emerged critical mechanism underlying pollutant-induced toxicity. Numerous studies demonstrated that fine particulates, heavy metals, organic substances can trigger ferroptosis, which is closely intertwined with lipid, iron, amino acid metabolism. Given growing evidence linking severe diseases such heart failure, chronic obstructive pulmonary disease, liver injury, Parkinson's Alzheimer's cancer, it imperative investigate ferroptosis. In this review, we comprehensively analyze pathways intricate signaling molecules elucidate integration into driving braking axes. Furthermore, discuss potential hazards associated organs four representative animal models. Finally, provide an outlook on future research directions strategies aimed at preventing By enhancing our understanding novel developing effective preventive measures, mitigate effects environmental safeguard health.
Language: Английский
Citations
32
Journal of Allergy and Clinical Immunology, Journal Year: 2024, Volume and Issue: 153(5), P. 1194 - 1205
Published: Feb. 2, 2024
Climate change is not just jeopardizing the health of our planet, but it increasingly impacting immune health.There an expanding body evidence that climaterelated exposures, such as air pollution, heat, wildfires, extreme weather events, and biodiversity loss significantly disrupt functioning human system.These exposures manifest in a broad range stimuli including antigens, allergens, heat stress, pollutants, microbiota changes, other toxic substances.Such pose direct indirect threat to body's primary line defense, epithelial barrier, affecting its physical integrity functional efficacy.Furthermore, these climate-related environmental stressors can hyper-stimulate innate system influence adaptive immunity, notably terms developing preserving tolerance.The or failure tolerance instigate wide spectrum non-communicable diseases autoimmune conditions, allergy, respiratory illnesses, metabolic diseases, obesity, others.As continues unravel, there need for additional research climate immunology covers diverse environments different global settings, employing modern biological epidemiological tools.
Language: Английский
Citations
20
Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 115 - 115
Published: Jan. 7, 2025
Postoperative neurocognitive dysfunction (PND) is a prevalent and debilitating complication in elderly surgical patients, characterized by persistent cognitive decline that negatively affects recovery quality of life. As the aging population grows, rising number patients has made PND an urgent clinical challenge. Despite increasing research efforts, pathophysiological mechanisms underlying remain inadequately characterized, underscoring need for more integrated framework to guide targeted interventions. To better understand molecular therapeutic targets PND, this narrative review synthesized evidence from peer-reviewed studies, identified through comprehensive searches PubMed, Embase, Cochrane Library, Web Science. Key findings highlight neuroinflammation, oxidative stress, mitochondrial dysfunction, neurotransmitter imbalances, microvascular changes, white matter lesions as central pathophysiology, with particular parallels encephalocele- sepsis-associated impairments. Among these, mediated pathways such NLRP3 inflammasome blood-brain barrier disruption, emerges pivotal driver, triggering cascades exacerbate neuronal injury. Oxidative stress synergistically amplify these effects, while imbalances alterations, including lesions, contribute synaptic decline. Anesthetic agents modulate interconnected pathways, exhibiting both protective detrimental effects. Propofol dexmedetomidine demonstrate neuroprotective properties suppressing neuroinflammation microglial activation, whereas inhalational anesthetics like sevoflurane intensify inflammatory responses. Ketamine, its anti-inflammatory potential, offers promise but requires further evaluation determine long-term safety efficacy. By bridging insights practice, highlights critical role personalized anesthetic strategies mitigating improving patients. It aims inform future decision-making address multifaceted
Language: Английский
Citations
2
Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 11
Published: Jan. 20, 2021
Background: Considering the pivotal role of inflammasome/pyroptosis in biological function, we visually analyzed research hotspots related to brain this work through method bibliometrics from Web Science (WOS) Core database over past two decades. Methods: Documents were retrieved WOS Collection on October 16, 2020. The search terms and strategies used for are as follow: # 1, “pyroptosis”; 2, “pyroptotic”; 3, “inflammasome”; 4, “pyroptosome”; 5 “brain”; 6, “# 1” OR 2” 3” 4”; 7, 5” AND 6”. We selected articles reviews published English 2000 Visualization analysis statistical performed by VOSviewer 1.6.15 CiteSpace 5.7. R2. Results: 1,222 documents analysis. In approximately 20 years since pyroptosis was first presented, publications regarding inflammasome presented 2005. number annual increased gradually a decade, which involved work, will continue increase most prolific country China with 523 but United States 16,328 citations. influential author Juan Pablo de Rivero Vaccari 27 who worked at University Miami. bibliometric showed that variety cell types (microglia, astrocyte, neuron, etc.), physiological processes, ER stress, mitochondrial oxidative disease (traumatic injuries, stroke, Alzheimer’s disease, Parkinson’s disease). Conclusion: be hotspot. recommend investigating mechanism molecules complex crosstalk regulated deaths (RCDs) glial cells, facilitate development effective therapeutic targeting large-scale clinical trials. Thus, study presents trend characteristic brain, provided helpful researchers further studies.
Language: Английский
Citations
78
Ecotoxicology and Environmental Safety, Journal Year: 2022, Volume and Issue: 242, P. 113893 - 113893
Published: July 31, 2022
Due to the highly evolved industrialization and modernization, air quality has deteriorated in most countries. As reported by World Health Organization (WHO), pollution is now considered as one of major threats global health a principal risk factor for noncommunicable diseases. Meanwhile, increasing worldwide prevalence overweight obesity attracting more public attentions. Recently, accumulating epidemiological studies have provided evidence that may be partially attributable environmental exposure pollution. This review summarizes correlation between various outdoor indoor pollutants (mainly particulate matter (PM), nitrogen oxides (NOx), ozone (O3), polycyclic aromatic hydrocarbons (PAHs)) outcomes recent years. Moreover, it discusses multiple effects during periods throughout life sex differences populations. also describes potential mechanism underlying increased caused pollution, including inflammation, oxidative stress, metabolic imbalance, intestinal flora disorders epigenetic modifications. Finally, this proposes macro- micro-measures prevent negative on prevalence.
Language: Английский
Citations
57
DNA and Cell Biology, Journal Year: 2022, Volume and Issue: 41(11), P. 924 - 934
Published: Nov. 1, 2022
Endoplasmic reticulum (ER) stress and oxidative (OS) are often related states in cells as part of normal physiology but more frequently manifested the pathophysiology many diseases, particularly diseases involving acute or chronic inflammation. In this study, we reviewed recent findings about role ER OS pathogenesis inflammatory diseases.
Language: Английский
Citations
40
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(9), P. 8011 - 8011
Published: April 28, 2023
Ferulic acid (FA), a prevalent dietary phytochemical, has many pharmacological effects, including anti-oxidation and anti-inflammation been widely used in the pharmaceutical, food, cosmetics industries. Many studies have shown that FA can significantly downregulate expression of reactive oxygen species activate nuclear factor erythroid-2-related factor-2/heme oxygenase-1 signaling, exerting anti-oxidative effects. The anti-inflammatory effect is mainly related to p38 mitogen-activated protein kinase factor-kappaB signaling pathways. demonstrated potential clinical applications treatment pulmonary diseases. transforming growth factor-β1/small mothers against decapentaplegic 3 pathway be blocked by FA, thereby alleviating fibrosis. Moreover, context asthma, T helper cell 1/2 imbalance restored FA. Furthermore, ameliorates acute lung injury inhibiting pathways via toll-like receptor 4, consequently decreasing downstream inflammatory mediators. Additionally, there moderate neuraminidase inhibitory activity showing tendency reduce interleukin-8 level response influenza virus infections. Although application broad prospects, more preclinical mechanism-based research should carried out test these settings. This review not only covers literature on effects mechanisms but also discusses therapeutic role toxicology several
Language: Английский
Citations
37