Long noncoding RNA SNHG15: A promising target in human cancers DOI Creative Commons

Niu Zhang,

Tianyao Lei,

Tianwei Xu

et al.

Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13

Published: March 28, 2023

As oncogenes or tumor suppressor genes, lncRNAs played an important role in tumorigenesis and the progression of human cancers. The lncRNA SNHG15 has recently been revealed to be dysregulated malignant tumors, suggesting aberrant expression which contributes clinical features regulates various oncogenic processes. We have selected extensive literature focused on from electronic databases, including studies relevant its significance critical events cancer-related processes such as cell proliferation, apoptosis, autophagy, metastasis, drug resistance. This review summarized current understanding cancer, mainly focusing pathological features, known biological functions, underlying molecular mechanisms. Furthermore, well-documented effective diagnostic prognostic marker for offering novel therapeutic interventions specific subsets cancer cells.

Language: Английский

Tumor immune microenvironment lncRNAs DOI Creative Commons

Eun-Gyeong Park,

Sung-Jin Pyo,

Youxi Cui

et al.

Briefings in Bioinformatics, Journal Year: 2021, Volume and Issue: 23(1)

Published: Nov. 5, 2021

Abstract Long non-coding ribonucleic acids (RNAs) (lncRNAs) are key players in tumorigenesis and immune responses. The nature of their cell type-specific gene expression other functional evidence support the idea that lncRNAs have distinct cellular functions tumor microenvironment (TIME). To date, majority lncRNA studies heavily relied on bulk RNA-sequencing data which various types contribute to an averaged signal, limiting discovery functions. Single-cell (scRNA-seq) is a potential solution for tackling this limitation despite lack annotations low abundance yet lncRNAs. Hence, updated further understanding will be necessary characterizing genes TIME. In review, we discuss specifically expressed cells, summarize regulatory at type level highlight how scRNA-seq approach can help study TIME

Language: Английский

Citations

156
Epigenetic modifications: Key players in cancer heterogeneity and drug resistance DOI Creative Commons
Hana Q. Sadida,

Alanoud Abdulla,

Sara Al Marzooqi

et al.

Translational Oncology, Journal Year: 2023, Volume and Issue: 39, P. 101821 - 101821

Published: Nov. 4, 2023

Cancer heterogeneity and drug resistance remain pivotal obstacles in effective cancer treatment management. One major contributor to these challenges is epigenetic modifications - gene regulation that does not involve changes the DNA sequence itself but significantly impacts expression. As we elucidate phenomena, underscore role of regulating expression, contributing cellular diversity, driving adaptive can instigate therapeutic resistance. This review dissects essential methylation, histone modifications, chromatin remodeling illustrating their significant yet complex contributions biology. While offer potential avenues for intervention due reversible nature, interplay genetic cells presents unique must be addressed harness full potential. By critically analyzing current research landscape, identify knowledge gaps propose future directions, exploring therapies discussing translating concepts into treatments. comprehensive aims stimulate further aid developing innovative, patient-centered therapies. Understanding critical scientific advancement paves way towards improving patient outcomes fight against this formidable disease.

Language: Английский

Citations

50
RNA-mediated immunotherapy regulating tumor immune microenvironment: next wave of cancer therapeutics DOI Creative Commons
Poonam R. Pandey, Ken H. Young, Dhiraj Kumar

et al.

Molecular Cancer, Journal Year: 2022, Volume and Issue: 21(1)

Published: Feb. 21, 2022

Abstract Accumulating research suggests that the tumor immune microenvironment (TIME) plays an essential role in regulation of growth and metastasis. The cellular molecular nature TIME influences cancer progression metastasis by altering ratio immune- suppressive versus cytotoxic responses vicinity tumor. Targeting or activating components show a promising therapeutic avenue to combat cancer. success immunotherapy is both astounding unsatisfactory clinic. Advancements RNA-based technology have improved understanding complexity diversity its effects on therapy. TIME-related RNA regulators could be targets for anticancer immunotherapy. In this review, we discuss available immunotherapies targeting TIME. More importantly, summarize potential various therapeutics clinically treatment. RNA-dependent TIME, as monotherapy combined with other evolving therapeutics, might beneficial patients’ treatment near future.

Language: Английский

Citations

60
Exosomal long non-coding RNAs in cancer: Interplay, modulation, and therapeutic avenues DOI Creative Commons
Rahaba Marima, Afra Basera, Thabiso Victor Miya

et al.

Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 9(3), P. 887 - 900

Published: April 4, 2024

In the intricate field of cancer biology, researchers are increasingly intrigued by emerging role exosomal long non-coding RNAs (lncRNAs) due to their multifaceted interactions, complex modulation mechanisms, and potential therapeutic applications. These lncRNAs, carried within extracellular vesicles, play a vital partin tumorigenesis disease progression facilitating communication networks between tumor cells local microenvironment, making them an ideal candidates for use in liquid biopsy approach. However, lncRNAs remain understudied area, especially biology. Therefore this review aims comprehensively explore dynamic interplay various cellular components, including interactions with tumor-stroma, immune modulation, drug resistance mechanisms. Understanding regulatory functions these processes can potentially unveil novel diagnostic markers targets cancer. Additionally, emergence RNA-based therapeutics presents exciting opportunities targeting offering innovative strategies combat improve treatment outcomes. Thus, provides insights into current understanding highlighting crucial roles, evolving landscape interventions. Furthermore, we have also discussed advantage exosomes as carriers development personalized targeted therapy patients.

Language: Английский

Citations

14
Connecting the Dots: LncRNAs in the KRAS Pathway and Cancer DOI
Mudasir Maqbool, Md Sadique Hussain, Ajay Singh Bisht

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 262, P. 155570 - 155570

Published: Aug. 29, 2024

Language: Английский

Citations

10
Long non-coding RNAs in cancer: multifaceted roles and potential targets for immunotherapy DOI
Lokesh Kadian, Deepika Verma, Neelam Lohani

et al.

Molecular and Cellular Biochemistry, Journal Year: 2024, Volume and Issue: 479(12), P. 3229 - 3254

Published: Feb. 28, 2024

Language: Английский

Citations

8
Comprehensive Analysis of Necroptosis-Related Long Noncoding RNA Immune Infiltration and Prediction of Prognosis in Patients With Colon Cancer DOI Creative Commons

Li Liu,

Liu Huang, Wenzheng Chen

et al.

Frontiers in Molecular Biosciences, Journal Year: 2022, Volume and Issue: 9

Published: Feb. 14, 2022

Colon cancer (CC) is one of the most frequent malignancies in world, with a high rate morbidity and death. In CC, necroptosis long noncoding RNA (lncRNAs) are crucial, but mechanism not completely clear. The goal this study was to create new signature that might predict patient survival tumor immunity patients CC. Expression profiles necroptosis-related lncRNAs 473 CC were retrieved from TCGA database. A consensus clustering analysis based on differentially expressed (DE) genes prognostic model least absolute shrinkage selection operator (LASSO) regression conducted. Clinicopathological correlation analysis, expression difference PCA, TMB, GO KEGG enrichment immune prediction clinical therapeutic compounds, qRT-PCR also Fifty-six found be linked prognosis, performed. There substantial variations survival, checkpoint expression, clinicopathological correlations, among different subgroups. Six discovered, split into high-risk low-risk groups risk score generated using these six lncRNAs. time considerably longer than patients, indicating directly associated survival. stage, infiltration depth, lymph node metastasis, distant metastasis. After univariate multivariate Cox stage remained significant. Cancer- metabolism-related pathways enriched by analyses. Immune shown differ significantly between high- immunoassay. Eight compounds screened out, confirmed differential Overall, have an important function, prognosis can predicted They may useful future for customized therapy.

Language: Английский

Citations

36
The Role of Long Non-Coding RNAs in the Tumor Immune Microenvironment DOI Creative Commons
Yingli Guo,

Yajuan Xie,

Yao Luo

et al.

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Feb. 9, 2022

Tumorigenesis is a complicated process caused by successive genetic and epigenetic alterations. The past decades demonstrated that the immune system affects tumorigenesis, tumor progression, metastasis. Although increasing immunotherapies are revealed, only tiny proportion of them effective. Long non-coding RNAs (lncRNAs) class single-stranded RNA molecules larger than 200 nucleotides essential in molecular network oncology immunology. Increasing researches have focused on connection between lncRNAs cancer immunotherapy. However, in-depth mechanisms still elusive. In this review, we outline latest studies functions microenvironment. Via participating various biological processes such as neutrophil recruitment, macrophage polarization, NK cells cytotoxicity, T functions, regulate invasion, epithelial-mesenchymal transition (EMT), angiogenesis. addition, reviewed current understanding relevant strategies for targeting lncRNAs. LncRNAs-based therapeutics may represent promising approaches serving prognostic biomarkers or potential therapeutic targets cancer, providing ideas future research clinical application diagnosis therapies.

Language: Английский

Citations

33
(Dis)similarities between the Decidual and Tumor Microenvironment DOI Creative Commons
Jelena Krstić, Alexander Deutsch, Julia Fuchs

et al.

Biomedicines, Journal Year: 2022, Volume and Issue: 10(5), P. 1065 - 1065

Published: May 4, 2022

Placenta-specific trophoblast and tumor cells exhibit many common characteristics. Trophoblast invade maternal tissues while being tolerated by the immune system. Similarly, can surrounding escape Importantly, both are supported an abetting microenvironment, which influences invasion, angiogenesis, tolerance/evasion, among others. However, in contrast to cells, metabolic, proliferative, migrative, invasive states of under tight regulatory control. In this review, we provide overview similarities dissimilarities processes that drive cell fate, particularly focusing on role microenvironments.

Language: Английский

Citations

25
Lipid metabolism–related lncRNA SLC25A21‐AS1 promotes the progression of oesophageal squamous cell carcinoma by regulating the NPM1/c‐Myc axis and SLC25A21 expression DOI Creative Commons
Yu Liu, Chunxiang Li, Lingling Fang

et al.

Clinical and Translational Medicine, Journal Year: 2022, Volume and Issue: 12(6)

Published: June 1, 2022

Obesity alters metabolic microenvironment and is thus associated with several tumours. The aim of the present study was to investigate role, molecular mechanism action, potential clinical value lipid metabolism-related long non-coding RNA (lncRNA) SLC25A21-AS1 in oesophageal squamous cell carcinoma (ESCC).A high-fat diets (HFDs)-induced obesity nude mouse model established, targeted metabolomics analysis used identify critical medium-long chain fatty acids influencing growth ESCC cells. Transcriptomic public dataset GSE53625 confirmed that lncRNA a lncRNA. biological function investigated both vivo vitro. Chromatin immunoprecipitation(ChIP)assay, RNA-pull down, mass spectrometry, co-IP, IP(RIP) were performed explore mechanism. Finally, an cDNA microarray determine prognostic by RT-qPCR.Palmitic acid (PA) important component HFD had inhibitory effect on lines. LncRNA expression downregulated PA proliferation migration cells vitro vivo. Mechanistically, interacted nucleophosmin-1 (NPM1) protein promote downstream gene transcription c-Myc nucleus. In cytoplasm, maintained stability SLC25A21 mRNA reduced intracellular NAD+ /NADH ratio tryptophan catabolism. we demonstrated high promoted resistance cisplatin-induced apoptosis correlated poor tumour grade overall survival.HFD/PA has expression. promotes regulating NPM1/c-Myc axis addition, may serve as favourable biomarker therapeutic target for ESCC.

Language: Английский

Citations

24