Frontiers in Oncology,
Journal Year:
2023,
Volume and Issue:
13
Published: March 28, 2023
As
oncogenes
or
tumor
suppressor
genes,
lncRNAs
played
an
important
role
in
tumorigenesis
and
the
progression
of
human
cancers.
The
lncRNA
SNHG15
has
recently
been
revealed
to
be
dysregulated
malignant
tumors,
suggesting
aberrant
expression
which
contributes
clinical
features
regulates
various
oncogenic
processes.
We
have
selected
extensive
literature
focused
on
from
electronic
databases,
including
studies
relevant
its
significance
critical
events
cancer-related
processes
such
as
cell
proliferation,
apoptosis,
autophagy,
metastasis,
drug
resistance.
This
review
summarized
current
understanding
cancer,
mainly
focusing
pathological
features,
known
biological
functions,
underlying
molecular
mechanisms.
Furthermore,
well-documented
effective
diagnostic
prognostic
marker
for
offering
novel
therapeutic
interventions
specific
subsets
cancer
cells.
Non-Coding RNA,
Journal Year:
2023,
Volume and Issue:
9(5), P. 52 - 52
Published: Aug. 28, 2023
Non-coding
RNAs
(ncRNAs)
are
a
group
of
molecules
critical
for
cell
development
and
growth
regulation.
They
key
regulators
important
cellular
pathways
in
the
tumor
microenvironment.
To
analyze
ncRNAs
microenvironment,
use
RNA
sequencing
technology
has
revolutionized
field.
The
advancement
this
technique
broadened
our
understanding
molecular
biology
cancer,
presenting
abundant
possibilities
exploration
novel
biomarkers
cancer
treatment.
In
review,
we
will
summarize
recent
achievements
complex
role
ncRNA
report
latest
studies
on
microenvironment
using
sequencing,
discuss
potential
as
therapeutics
treatment
cancer.
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: Aug. 21, 2023
Gastric
cancer
(GC)
is
a
highly
prevalent
and
deadly
malignant
neoplasm
worldwide.
Currently,
long
non-coding
RNAs
(lncRNAs)
have
recently
been
identified
as
crucial
regulators
implicated
in
GC
development
progression.
Dysregulated
expression
of
lncRNAs
commonly
associated
with
enhanced
tumor
migration,
invasiveness,
therapy
resistance,
highlighting
their
potential
promising
targets
for
clinical
applications.
This
review
offers
comprehensive
historical
overview
GC,
describes
the
molecular
mechanisms,
discusses
prospects
challenges
establishing
precision
biomarkers.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Aug. 27, 2024
Cancer
treatment
has
long
been
fraught
with
challenges,
including
drug
resistance,
metastasis,
and
recurrence,
making
it
one
of
the
most
difficult
diseases
to
treat
effectively.
Traditional
therapeutic
approaches
often
fall
short
due
their
inability
target
cancer
stem
cells
complex
genetic
epigenetic
landscape
tumors.
In
recent
years,
immunotherapy
revolutionized
field,
offering
new
hope
viable
alternatives
conventional
treatments.
A
particularly
promising
area
research
focuses
on
non-coding
RNAs
(ncRNAs),
especially
(lncRNAs),
role
in
resistance
modulation
signaling
pathways.
To
address
these
we
performed
a
comprehensive
review
studies
lncRNAs
impact
immunotherapy.
Our
highlights
crucial
roles
that
play
affecting
both
innate
adaptive
immunity,
thereby
influencing
outcomes
Key
observations
from
our
indicate
can
modify
tumor
immune
microenvironment,
enhance
cell
infiltration,
regulate
cytokine
production,
all
which
contribute
growth
therapies.
These
insights
suggest
could
serve
as
potential
targets
for
precision
medicine,
opening
up
avenues
developing
more
effective
immunotherapies.
By
compiling
across
various
cancers,
this
aims
shed
light
mechanisms
within
microenvironment.
Frontiers in Oncology,
Journal Year:
2023,
Volume and Issue:
13
Published: March 28, 2023
As
oncogenes
or
tumor
suppressor
genes,
lncRNAs
played
an
important
role
in
tumorigenesis
and
the
progression
of
human
cancers.
The
lncRNA
SNHG15
has
recently
been
revealed
to
be
dysregulated
malignant
tumors,
suggesting
aberrant
expression
which
contributes
clinical
features
regulates
various
oncogenic
processes.
We
have
selected
extensive
literature
focused
on
from
electronic
databases,
including
studies
relevant
its
significance
critical
events
cancer-related
processes
such
as
cell
proliferation,
apoptosis,
autophagy,
metastasis,
drug
resistance.
This
review
summarized
current
understanding
cancer,
mainly
focusing
pathological
features,
known
biological
functions,
underlying
molecular
mechanisms.
Furthermore,
well-documented
effective
diagnostic
prognostic
marker
for
offering
novel
therapeutic
interventions
specific
subsets
cancer
cells.
