International Journal of Epidemiology,
Journal Year:
2023,
Volume and Issue:
52(3), P. 703 - 714
Published: Jan. 11, 2023
Abstract
Background
Smoking
and
occupational
pulmonary
irritants
contribute
to
multiple
sclerosis
(MS)
development.
We
aimed
study
the
association
between
ambient
air
pollution
MS
risk
potential
interaction
with
human
leukocyte
antigen
(HLA)-DRB1*15:01
allele.
Methods
Exposure
combustion-related
was
estimated
as
outdoor
levels
of
nitrogen
oxides
(NOx)
at
participants’
residence
locations,
by
spatially
resolved
dispersion
modelling
for
years
1990–18.
Using
two
population-based
case-control
studies
(6635
cases,
8880
controls),
NOx
were
associated
calculating
odds
ratios
(OR)
95%
confidence
intervals
(CI)
using
logistic
regression
models.
Interaction
high
HLA-DRB1*15:01
allele
regarding
calculated
attributable
proportion
due
(AP).
In
addition,
a
register
performed
comprising
all
cases
in
Sweden
who
had
received
their
diagnosis
1993
2018
(n
=
22
173),
10
controls
per
case
randomly
selected
from
National
Population
register.
Results
Residential
risk.
(3-year
average)
exceeding
90th
percentile
(24.6
µg/m3)
an
OR
1.37
(95%
CI
1.10–1.76)
compared
below
25th
(5.9
µg/m3),
trend
increasing
(P
<0.0001).
A
synergistic
effect
observed
(exceeding
lower
quartile
among
controls)
(AP
0.26,
0.13–0.29).
Conclusions
Our
findings
indicate
that
moderate
may
play
role
Cellular and Molecular Immunology,
Journal Year:
2024,
Volume and Issue:
21(11), P. 1183 - 1200
Published: Oct. 8, 2024
The
IL-23
signaling
pathway
in
both
innate
and
adaptive
immune
cells
is
vital
for
orchestrating
type
17
immunity,
which
marked
by
the
secretion
of
signature
cytokines
such
as
IL-17,
IL-22,
GM-CSF.
These
proinflammatory
mediators
play
indispensable
roles
maintaining
intestinal
equilibrium
mucosal
host
defense;
however,
their
involvement
has
also
been
implicated
pathogenesis
chronic
inflammatory
disorders,
bowel
diseases
autoimmunity.
However,
implications
immunity
across
diverse
inflammation
models
are
complex.
This
review
provides
a
comprehensive
overview
multifaceted
these
gut
homeostasis
perturbing
barrier
integrity,
leading
to
acute
various
infection
colitis.
Additionally,
this
focuses
on
interconnecting
multiple
organs
autoimmune
conditions,
with
particular
emphasis
arthritis
neuroinflammation
driven
T
primed
within
microenvironment.
Journal of Medical Cases,
Journal Year:
2024,
Volume and Issue:
15(4-5), P. 82 - 91
Published: May 1, 2024
This
case
report
describes
a
novel
therapy
for
patients
with
severe
autism
spectrum
disorder
(ASD)
that
is
worth
further
investigation.
A
19-year-old
male
adolescent
ASD,
who
was
not
responding
to
standard
treatment
received
fecal
microbiota
transplant
(FMT)
using
donor
material
from
his
typically
developing
female
sibling.
The
patient's
ASD
symptoms
were
assessed
by
assessors
blind
the
past
symptomatology.
Assessors
used
Childhood
Autism
Rating
Scale
(CARS),
an
observation-based
rating
scale
assess
developmental
delay
in
children
(range
of
CARS
scores
15
-
60;
score
>
28
indicative
autism;
higher
positively
correlated
degree
severity),
at
baseline
and
again
six
timepoints
post-FMT.
patient
experienced
marked
improvements
microbiome
diversity
composition
over
year
half
period
followed
FMT
procedure.
Additionally,
previously
nonverbal
said
first
two
words
reduction
aggression
1-month
To
authors'
knowledge,
this
demonstrate
use
familial
ASD.
Given
symptom
post-FMT
tend
occur
younger
patients,
authors
hypothesize
may
be
important
factor
contributed
improved
outcomes
older
child.
Journal of Clinical Medicine,
Journal Year:
2022,
Volume and Issue:
11(7), P. 1941 - 1941
Published: March 31, 2022
Urinary,
bowel,
and
sexual
dysfunctions
are
the
most
frequent
disabling
pelvic
floor
(PF)
disorders
in
patients
with
multiple
sclerosis
(MS).
PF
dysfunction
negatively
impacts
performance
of
daily
living
activities,
walking,
physical
dimension
quality
life
(QoL)
people
MS.
Patient-reported
outcomes
on
sphincteric
functioning
could
be
useful
to
detect
their
impact
patients’
lives.
rehabilitation
proposed
by
Kegel
is
based
a
series
regularly
repeated
exercises
for
“the
functional
restoration
perineal
muscles”.
Over
time,
various
therapeutic
modalities
have
been
added
muscles
exercises,
through
application
or
instrumental
techniques,
such
as
intravaginal
neuromuscular
electrical
stimulation,
electromyographic
biofeedback,
transcutaneous
tibial
nerve
stimulation.
has
applied
MS
treatment,
improvements
lower
urinary
tract
symptoms
severity,
QoL,
level
anxiety
depression,
dysfunction.
This
review
aims
examine
different
evaluate
highlight
its
advantages
limits,
suggesting
multidisciplinary
management
disorders,
well-deserved
space
reserved
rehabilitation.
Cells,
Journal Year:
2023,
Volume and Issue:
12(5), P. 684 - 684
Published: Feb. 21, 2023
Severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
is
an
exceptionally
transmissible
and
pathogenic
that
appeared
at
the
end
of
2019
triggered
a
pandemic
disease,
known
as
disease
(COVID-19).
COVID-19
can
evolve
into
severe
associated
with
immediate
delayed
sequelae
in
different
organs,
including
central
nervous
system
(CNS).
A
topic
deserves
attention
this
context
complex
relationship
between
SARS-CoV-2
infection
multiple
sclerosis
(MS).
Here,
we
initially
described
clinical
immunopathogenic
characteristics
these
two
illnesses,
accentuating
fact
can,
defined
patients,
reach
CNS,
target
tissue
MS
autoimmune
process.
The
well-known
contribution
viral
agents
such
Epstein-Barr
virus
postulated
participation
risk
factor
for
triggering
or
worsening
are
then
described.
We
emphasize
vitamin
D
scenario,
considering
its
relevance
susceptibility,
severity
control
both
pathologies.
Finally,
discuss
experimental
animal
models
could
be
explored
to
better
understand
interplay
diseases,
possible
use
adjunct
immunomodulator
treat
them.
