COVID-19 Autopsies Reveal Underreporting of SARS-CoV-2 Infection and Scarcity of Co-infections

Frontiers in Medicine, Journal Year: 2022, Volume and Issue: 9

Published: April 14, 2022

Coronavirus disease 2019 (COVID-19) mortality can be estimated based on reliable data. Variable testing procedures and heterogeneous course suggest that a substantial number of COVID-19 deaths is undetected. To address this question, we screened an unselected autopsy cohort for the presence SARS-CoV-2 panel common respiratory pathogens. Lung tissues from 62 consecutive autopsies, conducted during first second pandemic waves in Switzerland, were analyzed bacterial, viral fungal pathogens including SARS-CoV-2. was detected 28 lungs deceased patients (45%), although only 18 (29%) reported to have at time death. In 23 (37% all), clinical cause death and/or findings together with suggested due COVID-19. Our results reveal 16% higher infection rate 8% related than by clinicians before The majority infected (75%) did not suffer co-infections, as long they treated antibiotics. 5 (8% found, yet without typical findings. underreporting contributes substantially excess mortality. small percentage co-infections positive who died symptoms strongly suggests virus.

Language: Английский

---

A Physiotherapy Treatment Plan for Post-COVID-19 Patients That Improves the FEV1, FVC, and 6-Min Walk Values, and Reduces the Sequelae in 12 Sessions

Frontiers in Rehabilitation Sciences, Journal Year: 2022, Volume and Issue: 3

Published: May 30, 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causal agent of Coronavirus disease 2019 (COVID-19), a pandemic declared in 2020. The clinical manifestations this pathology are heterogeneous including fever, cough, dyspnea, anosmia, headache, fatigue, taste dysfunction, among others. Survivors COVID-19 have demonstrated several persistent symptoms derived from its multisystemic physiopathology. These can be chest pain, dry and productive insufficiency, psychoemotional disturbance. To reduce recover post-COVID-19 sequelae fundamental an early multifactorial medical treatment. Integral physiotherapy tool to improve lung capacity, decrease alterations, as well increase muscle strength affected by disease. Thus, aim study was establish novel physiotherapeutic plan for patients, evaluating effect treatment reduction terms cardio-respiratory, muscular improvements. This cross-sectional which protocol 12 sessions 4 weeks implemented patients enrolled. We conducted assessment, interview, DASS-21 test, spirometry, 6-min walk hand dynamometer test evaluate post-COVID condition before after sessions. A total 42 participated program. Results work showed around 50% improvement status patients. Also, we observed 7.16% FEV1 value 7.56% FVC. In addition, maximal functional capacity increased 0.577 METs, performance 13%, SpO2 improved 1.40%. Finally, handgrip left right 2.90 2.24 Kg, respectively. developed propose methodology provide information better management

Language: Английский

---

Clinical characteristics and histopathology of COVID-19 related deaths in South African adults

PLoS ONE, Journal Year: 2022, Volume and Issue: 17(1), P. e0262179 - e0262179

Published: Jan. 20, 2022

Comparisons of histopathological features and microbiological findings between decedents with respiratory symptoms due to SARS-CoV-2 infection or other causes, in settings high prevalence HIV Mycobacterium tuberculosis (MTB) infections have not been reported. Deaths associated a positive ante-mortem PCR test and/or disease at Chris Hani Baragwanath Academic Hospital Soweto, South Africa from 15th April 2nd November 2020, during the first wave African COVID-19 epidemic, were investigated. Deceased adult patients had post-mortem minimally-invasive tissue sampling (MITS) performed investigate for molecular detection putative pathogens on blood lung samples, histopathology examination lung, liver heart tissue. During study period MITS done displaying including 75 COVID-19-related deaths (COVID+) 42 non-COVID-19-related (COVID-). The HIV-infection was lower COVID+ (27%) than COVID- (64%), MTB also less common among (3% vs 13%). Lung showed differences severity morphological appearance Type-II pneumocytes, alveolar injury repair initiated by infection. In necrotising granulomatous inflammation more COVID+. No found analyses. bacterial co-infections higher Most indicators distress syndrome undifferentiated except pneumocytes. does appear these data meaningful correspondence COVID-related deaths.

Language: Английский

---

COVID-19 and thrombosis: Clinical features, mechanism of disease, and therapeutic implications

Kardiologia Polska, Journal Year: 2021, Volume and Issue: 79(11), P. 1197 - 1205

Published: Nov. 30, 2021

COVID-19 is a viral respiratory illness caused by the SARS-CoV-2 infection. In addition to lung disease, clinical complications of include myocardial damage and ischemia-related vascular disease. Severe manifestations poor prognosis in these patients are associated with hypercoagulable state predisposing thrombotic-related eventually death. However, features can also occur other forms pneumonia, such as community-acquired pneumonia (CAP), which, complicated diseases characterized platelet activation. Platelets play pivotal role settings bacteria viruses may induce activation via Toll-like receptors (TLRs) CAP different multiple pathways, including ACE2-AngII axis and/or TLRs, patients. Despite evidence confirming implication both settings, their contribution thrombotic process still under investigation. Thus, this review, we (1) compare infection CAP, (2) analyze putative mechanisms accounting for venous arterial thrombosis infection, (3) discuss potential anticoagulant armamentarium counteract

Language: Английский

---

Co-Infection Associated with SARS-CoV-2 and Their Management

Future Science OA, Journal Year: 2022, Volume and Issue: 8(9)

Published: Oct. 1, 2022

SARS-CoV-2 was discovered in Wuhan, China and quickly spread throughout the world. This deadly virus moved from person to person, resulting severe pneumonia, fever, chills hypoxia. Patients are still experiencing problems after recovering COVID-19. review covers COVID-19 associated issues following recovery COVID-19, as well multiorgan damage risk factors treatment techniques. Several unusual illnesses, including mucormycosis, white fungus infection, happy hypoxia other systemic abnormalities, have been reported recovered individuals. In children, multisystem inflammatory syndrome with (MIS-C) is identified. The reasons for this might include uncontrollable steroid usage, reduced immunity, diabetes mellitus inadequate care recovery.

Language: Английский

---