Clinical and Virological Features of Patients Hospitalized with Different Types of COVID-19 Vaccination in Mexico City DOI Creative Commons
Alejandra Hernández‐Terán,

Pamela Garcíadiego-Fossas,

Marco Villanueva-Reza

et al.

Vaccines, Journal Year: 2022, Volume and Issue: 10(8), P. 1181 - 1181

Published: July 26, 2022

Coronavirus disease 2019 (COVID-19) vaccines effectively protect against severe and death. However, the impact of vaccine used, viral variants, host factors on severity remain poorly understood. This work aimed to compare COVID-19 clinical presentations outcomes in vaccinated unvaccinated patients Mexico City. From March September 2021, clinical, demographic characteristics, variants were obtained from 1014 individuals with a documented SARS-CoV-2 infection. We compared unvaccinated, partially vaccinated, fully patients, stratifying by age groups. also fitted multivariate statistical models evaluate vaccination status, lineages, types, parameters. Most hospitalized unvaccinated. In over 61 years old, mortality was significantly higher individuals. aged 31 60 years, more likely be outpatients (46%) than (6.1%). found immune above old risk factors, while full most protective factor in-hospital study suggests that is essential reduce comorbid population such as Mexico.

Language: Английский

Antibody persistence and safety after heterologous boosting with orally aerosolised Ad5-nCoV in individuals primed with two-dose CoronaVac previously: 12-month analyses of a randomized controlled trial DOI Creative Commons
Lairun Jin, Rong Tang, Shipo Wu

et al.

Emerging Microbes & Infections, Journal Year: 2022, Volume and Issue: 12(1)

Published: Dec. 12, 2022

Antibody persistence and safety up to 12 months of heterologous orally administered adenovirus type-5 vector-based COVID-19 vaccine (Ad5-nCoV) in individuals who were primed with two-dose inactivated SARS-CoV-2 (CoronaVac) previously, has not been reported yet. This randomized, open-label, single-centre trial included Chinese adults have received CoronaVac randomized low-dose or high-dose aerosolised Ad5-nCoV group, group. In this report, we mainly evaluated the geometric mean titres (GMTs) neutralizing antibodies (NAbs) against live wild-type virus omicron BA.4/5 pseudovirus at after booster dose incidence serious adverse events (SAEs) till month 12. Of 419 participants, all analysis 120 (28.64%) immunogenicity analysis. Serum NAb GMT was 204.36 (95% CI 152.91, 273.14) group 171.38 121.27, 242.19) 12, significantly higher than (8.00 [95% 4.22, 15.17], p < 0.0001). 40.97 30.15, 55.67) 35.08 26.31, 46.77) whereas below lower limit detection. No vaccine-related SAEs observed. Orally following priming a good profile is persistently more immunogenic three-dose within dose.Trial registration: ClinicalTrials.gov identifier: NCT05043259..

Language: Английский

Citations

26
Immunization-induced antigen archiving enhances local memory CD8+ T cell responses following an unrelated viral infection DOI Creative Commons

Thu A. Doan,

Tadg Forward, Johnathon Schafer

et al.

npj Vaccines, Journal Year: 2024, Volume and Issue: 9(1)

Published: March 21, 2024

Abstract Antigens from viruses or immunizations can persist are archived in lymph node stromal cells such as lymphatic endothelial (LEC) and fibroblastic reticular (FRC). Here, we find that, during the time frame of antigen archiving, LEC apoptosis caused by a second, but unrelated, innate immune stimulus vaccina viral infection CpG DNA administration resulted cross-presentation antigens boosted memory CD8 + T specific to antigen. In contrast ”bystander” activation associated with unrelated infections, immunization were significantly higher than different specificity. Finally, increased protection against Listeria monocytogenes expressing immunization, only for duration that was archived. These findings outline an important mechanism which cell antigens, addition bystander activation, augment responses repeated inflammatory insults.

Language: Английский

Citations

4
Impact of vaccination on SARS-CoV-2 evolution and immune escape variants DOI

Deepak Jena,

Arup Ghosh,

Atimukta Jha

et al.

Vaccine, Journal Year: 2024, Volume and Issue: 42(21), P. 126153 - 126153

Published: Aug. 1, 2024

Language: Английский

Citations

4
Covalent inhibition of the SARS-CoV-2 NiRAN domain via an active-site cysteine DOI Creative Commons
Genaro Hernandez, Adam Osinski, Abir Majumdar

et al.

Journal of Biological Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 108378 - 108378

Published: March 1, 2025

Language: Английский

Citations

0
Vaccine breakthrough infections with SARS-CoV-2 Alpha mirror mutations in Delta Plus, Iota, and Omicron DOI Creative Commons
Brenda Martínez‐González, Lucía Vázquez-Sirvent, María Eugenia Soria

et al.

Journal of Clinical Investigation, Journal Year: 2022, Volume and Issue: 132(9)

Published: March 8, 2022

Replication of SARS-CoV-2 in the human population is defined by distributions mutants that are present at different frequencies within infected host and can be detected ultra-deep sequencing techniques. In this study, we examined mutant spectra amplicons from spike-coding (S-coding) region 5 nasopharyngeal isolates derived patients with vaccine breakthrough. Interestingly, all became Alpha variant, but amino acid substitutions correspond to Delta Plus, Iota, Omicron variants were resident virus. Deep analysis breakthrough revealed a rich reservoir types may also identify tolerated represented epidemiologically dominant variants.

Language: Английский

Citations

16
Adaptation‐Proof SARS‐CoV‐2 Vaccine Design DOI
Yashavantha L. Vishweshwaraiah, Brianna Hnath,

Brendan Rackley

et al.

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(49)

Published: Oct. 3, 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) surface spike glycoprotein - a major antibody target is critical for virus entry via engagement of human angiotensin-converting enzyme (ACE2) receptor. Despite successes with existing vaccines and therapies that primarily the receptor binding domain (RBD) protein, susceptibility RBD to mutations provides escape routes SARS-CoV-2 from neutralizing antibodies. On other hand, structural conservation in protein can be targeted reduce achieve broad protection. Here, we designed candidate stable immunogens mimic features selected conserved regions through 'epitope grafting,' which present epitope topology on diverse heterologous scaffolds structurally accommodate epitopes. Structural characterization epitope-scaffolds showed stark agreement our computational models The sera mice immunized engineered designs display activity. We also demonstrated utility diagnostic applications. Taken all together, study important methodology targeting conserved, non-RBD motifs vaccine design demonstrates potential grafting' rational design.

Language: Английский

Citations

13
Towards an Accurate Estimation of COVID-19 Cases in Kazakhstan: Back-Casting and Capture–Recapture Approaches DOI Creative Commons
Antonio Sarría‐Santamera,

Nurlan Abdukadyrov,

Natalya Glushkova

et al.

Medicina, Journal Year: 2022, Volume and Issue: 58(2), P. 253 - 253

Published: Feb. 8, 2022

Background and Objectives: Coronavirus disease 19 (COVID-19) has emerged as the most devastating syndemic of 21st century, with worrisome sustained consequences for entire society. Despite relative success vaccination programs, global threat novel coronavirus SARS-CoV-2 is still present further efforts are needed its containment control. Essential control getting closer to understanding actual extent infections. Material Methods: We a model based on mortality data Kazakhstan estimation underlying epidemic dynamic-with both lag time from infection death fatality rate. For number infected individuals in Kazakhstan, we used back-casting capture-recapture methods. Results: Our results suggest that despite increased testing capabilities official case reporting undercounts infections by at least 60%. Even though our count deaths may be either over or underestimated, methodology could more accurate approach following: magnitude pandemic; aiding identification different epidemiological values; reducing bias. Conclusions: optimal surveillance efforts, study lead an awareness effect COVID-19 this region globally, aid implementation effective screening diagnostic measures.

Language: Английский

Citations

11
Longitudinal analyses reveal distinct immune response landscapes in lung and intestinal tissues from SARS-CoV-2-infected rhesus macaques DOI Creative Commons
Huiwen Zheng, Yanli Chen, Jing Li

et al.

Cell Reports, Journal Year: 2022, Volume and Issue: 39(8), P. 110864 - 110864

Published: May 1, 2022

The pathological and immune response of individuals with COVID-19 display different dynamics in lung intestine. Here, we depict the single-cell transcriptional atlas longitudinally collected intestinal tissue samples from SARS-CoV-2-infected monkeys at 3 to 10 dpi. We find that enterocytes are degraded days post-infection but recovered rapidly, revealing infection has mild effects on Crucially, observe suppression inflammatory damage related B-cell Paneth cell accumulation intestines, although T cells activated SARS-CoV-2 infection. Compared lung, expression interferon response-related genes is inhibited, factor secretion reduced intestines. Our findings indicate an imbalance dynamic mucosa during infection, which may underlie ongoing rectal viral shedding damage.

Language: Английский

Citations

11
The emergence of the Omicron XBB.1.5 variant in India: a brief report on clinical presentation of a few cases DOI Creative Commons
Jasmine Samal, Arjun Bhugra, Varun Suroliya

et al.

Frontiers in Virology, Journal Year: 2023, Volume and Issue: 3

Published: June 2, 2023

Despite the three years spent navigating COVID-19 pandemic, scientists are still having to react disease due constant evolution of novel variants/subvariants. Over last few months, a global plummet in cases has suggested we transitioning towards endemic COVID-19. However, new omicron offshoots (XBB variants) driving surge around world. A preliminary research findings suggest that XBB.1.5 subvariant is more immune-evasive and displays higher binding ACE2 human receptor than its other related subvariants circulation. In this first-of-its-kind report, discuss clinical characteristics reported Delhi State, North India.

Language: Английский

Citations

5
Evolutionary Pattern Comparisons of the SARS-CoV-2 Delta Variant in Countries/Regions with High and Low Vaccine Coverage DOI Creative Commons
Jiahao Zhang,

Lin-qian Fan,

Hanli Xu

et al.

Viruses, Journal Year: 2022, Volume and Issue: 14(10), P. 2296 - 2296

Published: Oct. 19, 2022

It has been argued that vaccine-breakthrough infections of SARS-CoV-2 would likely accelerate the emergence novel variants with immune evasion. This study explored evolutionary patterns Delta variant in countries/regions relatively high and low vaccine coverage based on large-scale sequences. Our results showed (i) sequences were grouped into two clusters (L R); R cluster was dominant, its proportion increased over time higher high-vaccine-coverage areas; (ii) genetic diversities than those ones coverage; (iii) unique mutations co-mutations detected different countries/regions; particular, common exhibited highly occurring frequencies areas presented increasing (iv) five sites S protein under strong positive selection countries/regions, three non-C to U (I95T, G142D T950N), I95T higher, while T950N potentially immune-pressure-selected sites; (v) mutation at N6-methyladenosine site 4 ORF7a (C27527T, P45L) might be caused by pressure. suggested certain variation differences existed between coverage, but they not host We inferred no extra pressures generated we suggest promoting strengthening uptake COVID-19 worldwide, especially less developed areas.

Language: Английский

Citations

7