Journal of Clinical Medicine,
Journal Year:
2025,
Volume and Issue:
14(7), P. 2145 - 2145
Published: March 21, 2025
Background:
Hidradenitis
suppurativa
(HS)
is
a
chronic
inflammatory
skin
disease
often
associated
with
metabolic
disorders
such
as
diabetes
mellitus.
Recent
research
suggests
link
between
systemic
inflammation
and
insulin-glucose
dysregulation
in
HS.
This
study
investigates
the
relationship
homeostasis,
mellitus
haptoglobin
concentration
HS
patients.
Methods:
We
assessed
95
patients
49
controls
using
validated
fasting-based
function
tests,
including
Structural
Parameter
Inference
Approach
(SPINA),
Homeostasis
Model
Assessment
(HOMA)
Quantitative
Insulin
Sensitivity
Check
Index
(QUICKI).
Results:
The
had
significantly
higher
fasting
insulin
(97.2
vs.
69.0
pmol/L,
p
=
0.035),
increased
resistance
(HOMA-IR:
3.47
2.57,
0.016)
impaired
sensitivity
(SPINA-GR:
1.34
1.76
mol/s,
0.017).
In
diabetes,
was
more
strongly
reduced
0.61
1.41
0.0057)
7.3
3.2,
Higher
concentrations
were
accompanied
by
worse
glycaemic
control,
demonstrating
elevated
glucose
(5.77
5.11
mmol/L,
0.043)
HbA1c
(5.7%
5.4%,
0.0081)
fraction.
Conclusions:
Our
findings
suggest
that
contributes
to
dysregulation,
worsening
particularly
those
or
diabetes.
Current Issues in Molecular Biology,
Journal Year:
2024,
Volume and Issue:
46(1), P. 469 - 484
Published: Jan. 3, 2024
Inflammatory
diseases
are
a
global
health
problem
affecting
millions
of
people
with
wide
range
conditions.
These
diseases,
including
inflammatory
bowel
disease
(IBD),
rheumatoid
arthritis
(RA),
osteoarthritis
(OA),
gout,
and
diabetes,
impose
significant
burden
on
patients
healthcare
systems.
A
complicated
interaction
between
genetic
variables,
environmental
stimuli,
dysregulated
immune
responses
shows
the
complex
biological
foundation
various
diseases.
This
review
focuses
molecular
mechanisms
underlying
function
inflammasomes
inflammation.
We
investigate
impact
factors
progression
explore
connection
inflammation
inflammasome
activation,
examine
incidence
in
relation
to
inflammasomes.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(12), P. 6389 - 6389
Published: June 9, 2024
Long
COVID
(LC),
also
referred
to
as
Post
COVID-19
Condition,
Post-Acute
Sequelae
of
SARS-CoV-2
Infection
(PASC),
and
other
terms,
represents
a
complex
multisystem
disease
persisting
after
the
acute
phase
COVID-19.
Characterized
by
myriad
symptoms
across
different
organ
systems,
LC
presents
significant
diagnostic
management
challenges.
Central
disorder
is
role
low-grade
inflammation,
non-classical
inflammatory
response
that
contributes
chronicity
diversity
observed.
This
review
explores
pathophysiological
underpinnings
LC,
emphasizing
importance
inflammation
core
component.
By
delineating
pathogenetic
relationships
clinical
manifestations
this
article
highlights
necessity
for
an
integrated
approach
employs
both
personalized
medicine
standardized
protocols
aimed
at
mitigating
long-term
consequences.
The
insights
gained
not
only
enhance
our
understanding
but
inform
development
therapeutic
strategies
could
be
applicable
chronic
conditions
with
similar
features.
Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(3), P. 267 - 267
Published: Feb. 25, 2025
Diabetic
nephropathy
(DN),
one
of
the
most
common
and
severe
microvascular
complications
diabetes,
significantly
increases
risk
renal
failure
cardiovascular
events.
A
high-glucose
environment
can
lead
to
mitochondrial
dysfunction
in
macrophages,
which,
through
remodeling
energy
metabolism,
mediates
polarization
a
pro-inflammatory
phenotype
contributes
formation
chronic
inflammatory
microenvironment.
Recent
studies
have
found
that
stimulation
induces
dysregulation
nuclear
factor
erythroid
2-related
2
(NRF2)
redox
pathway
leading
generation
oxidative
stress
(OS)
further
drives
inflammation.
Therefore,
it
is
crucial
fully
understand
how
OS
affects
macrophage
phenotypes
functions
following
NRF2
inhibition.
This
review
analyzes
role
induced
by
inflammation
DN
explores
relationship
between
metabolism
NAD⁺/NADH-SIRT3
axis,
providing
new
therapeutic
targets
for
targeting
improve
microenvironment
vascular
damage
DN.
Journal of Clinical Medicine,
Journal Year:
2025,
Volume and Issue:
14(7), P. 2145 - 2145
Published: March 21, 2025
Background:
Hidradenitis
suppurativa
(HS)
is
a
chronic
inflammatory
skin
disease
often
associated
with
metabolic
disorders
such
as
diabetes
mellitus.
Recent
research
suggests
link
between
systemic
inflammation
and
insulin-glucose
dysregulation
in
HS.
This
study
investigates
the
relationship
homeostasis,
mellitus
haptoglobin
concentration
HS
patients.
Methods:
We
assessed
95
patients
49
controls
using
validated
fasting-based
function
tests,
including
Structural
Parameter
Inference
Approach
(SPINA),
Homeostasis
Model
Assessment
(HOMA)
Quantitative
Insulin
Sensitivity
Check
Index
(QUICKI).
Results:
The
had
significantly
higher
fasting
insulin
(97.2
vs.
69.0
pmol/L,
p
=
0.035),
increased
resistance
(HOMA-IR:
3.47
2.57,
0.016)
impaired
sensitivity
(SPINA-GR:
1.34
1.76
mol/s,
0.017).
In
diabetes,
was
more
strongly
reduced
0.61
1.41
0.0057)
7.3
3.2,
Higher
concentrations
were
accompanied
by
worse
glycaemic
control,
demonstrating
elevated
glucose
(5.77
5.11
mmol/L,
0.043)
HbA1c
(5.7%
5.4%,
0.0081)
fraction.
Conclusions:
Our
findings
suggest
that
contributes
to
dysregulation,
worsening
particularly
those
or
diabetes.
