UiO-based platforms in biomedicine: Advanced nanovehicles for effective treatment

Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 45, P. 102645 - 102645

Published: March 22, 2025

Language: Английский

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Causal relationship between sarcopenia with osteoarthritis and the mediating role of obesity: a univariate, multivariate, two-step Mendelian randomization study

BMC Geriatrics, Journal Year: 2024, Volume and Issue: 24(1)

Published: May 29, 2024

Abstract Background Recent genetic evidence supports a causal role for sarcopenia in osteoarthritis, which may be mediated by the occurrence of obesity or changes circulating inflammatory protein levels. Here, we leveraged publicly available genome-wide association study data to investigate intrinsic relationship between sarcopenia, obesity, levels, and osteoarthritis. Methods In this study, used Mendelian randomization analyses explore phenotypes (Appendicular lean mass [ALM], Low hand-grip strength [LHG], usual walking pace [UWP]) osteoarthritis (Knee [KOA], Hip [HOA]). Univariable (UVMR) were performed using inverse variance weighted (IVW) method, MR-Egger, median simple mode, with IVW method being primary analytical technique. Subsequently, independent effects phenotype on investigated multivariate (MVMR) analysis. To further mechanisms involved, proteins introduced as mediator variables, two-step analysis was mediating ALM KOA well proportions. Results UVMR showed ALM, LHG, UWP [(OR = 1.151, 95% CI: 1.087–1.218, P 1.19 × 10 –6 , FDR 7.14 ) (OR 1.215, 1.004–1.470; 0.046, 0.055) 0.503, 0.292–0.867; 0.013, 0.027)], HOA 1.181, 1.103–1.265, 2.05 6.15 0.438, 0.226–0.849, 0.014, 0.022)]. MVMR adjusting confounders (body index, insomnia, sedentary behavior, bone density), relationships observed [(ALM: OR 1.323, 95%CI: 1.224- 1.431, 2.07 –12 ), (LHG: 1.161, 1.044- 1.292, 0.006), (UWP: 0.511, 0.290- 0.899, 0.020)], (ALM: 1.245, 1.149- 1.348, 7.65 –8 ). MR analysis, identified play potential (proportion mediated: 5.9%). Conclusions The results suggest that decreased appendicular mass, grip strength, speed increase risk increases patients European population. Obesity plays due body reduction.

Language: Английский

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Phospholipase D2: A biomarker for stratifying disease severity in acute pancreatitis?

World Journal of Gastroenterology, Journal Year: 2025, Volume and Issue: 31(11)

Published: March 12, 2025

In this editorial, we critically evaluate the recent article by Niu et al , which explores potential of phospholipase D2 (PLD2) as a biomarker for stratifying disease severity in acute pancreatitis (AP). AP is clinically heterogeneous inflammatory condition that requires reliable biomarkers early and accurate classification severity. PLD2, an essential regulator neutrophil migration responses, has emerged promising candidate. Although current such C-reactive protein procalcitonin provide general indications inflammation, they lack specificity regarding molecular mechanisms underlying progression. Recent studies, including research conducted suggest inverse correlation between PLD2 expression severity, offering both diagnostic insights mechanistic understanding. This editorial evaluates role broader context research. Evidence indicates decreased levels are associated with increased chemotaxis cytokine release, contributing to pancreatic systemic inflammation. However, several challenges remain, need large-scale validation functional studies establish causation, standardization measurement protocols. Additionally, further investigation into temporal dynamics its variability across diverse populations warranted. Looking ahead, holds revolutionize management integrating diagnostics precision medicine. The utilization multi-omics approaches advancements platforms could position fundamental diagnosis, prognosis, potentially therapeutic targeting. While promising, it crucial conduct critical evaluations rigorous validations PLD2’s ensure efficacy improving patient outcomes.

Language: Английский

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Glabridin Suppresses Macrophage Activation by Lipoteichoic Acid In Vitro: The Crucial Role of MAPKs-IL-1β-iNOS Axis Signals in Peritoneal and Alveolar Macrophages

Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 174 - 174

Published: Jan. 24, 2025

Inflammation, a fundamental response to infection and injury, involves interactions among immune cells signaling molecules. Dysregulated inflammation contributes diseases such as autoimmune disorders cancer. Interleukin-1 beta (IL-1β), produced by macrophages in lipoteichoic acid (LTA) from Gram-positive bacteria, is key inflammatory mediator. Glabridin (GBD), bioactive compound licorice root, exhibits anti-inflammatory properties. This study investigates GBD’s effects on LTA-induced proinflammatory RAW 264.7 murine alveolar macrophages, MH-S, focusing IL-1β expression pathways. Cell viability assays confirmed that 20 μM GBD was non-cytotoxic. Confocal microscopy quantitative PCR showed significantly reduced fluorescence intensity, mRNA, protein levels. also inhibited inducible nitric oxide synthase (iNOS) (NO) production. Further analysis revealed suppressed NF-κB p65 nuclear translocation selectively modulated MAPK pathway activation reducing JNK p38 phosphorylation without affecting ERK. Studies using specific inhibitors demonstrated production reduction mechanistically linked inhibition. These findings highlight potential therapeutic agent for through its ability modulate critical mediators

Language: Английский

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Identification of the Cellular Tipping Point in the Inflammation Model of LPS-Induced RAW264.7 Macrophages Through Raman Spectroscopy and the Dynamical Network Biomarker Theory

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 920 - 920

Published: Feb. 17, 2025

Raman spectroscopy is a non-destructive spectroscopic technique that provides complex molecular information. It used to examine the physiological and pathological responses of living cells, such as differentiation, malignancy, inflammation. The two cellular states, initial full-blown inflammation, have mainly been investigated using comparative analysis with spectra. However, tipping point inflammatory state transition remains unclear. Therefore, present study attempted identify inflammation cell model. We stimulated RAW264.7 mouse macrophages lipopolysaccharide (LPS) continuously collected spectra every 2 h for 24 from states. A Partial Least Squares Principal Component Analysis-Linear Discriminant Analysis predicted 14 after LPS stimulation. In addition, Dynamical Network Biomarker (DNB) analysis, identifying in various phenomena, indicated was identified tryptophan biomarker. results multivariate DNB show point.

Language: Английский

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Advances in plant-derived vesicle like nanoparticles-based therapies for inflammatory diseases

Asian Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 101052 - 101052

Published: April 1, 2025

Language: Английский

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PathwayMind: An Innovative Tool and Database for Pathway Perturbation Analysis, Uncovering Critical Pathways for Drugs and Target Protein Sets

Computational Biology and Chemistry, Journal Year: 2025, Volume and Issue: 118, P. 108466 - 108466

Published: April 15, 2025

Language: Английский

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The Journey of p38 MAP Kinase Inhibitors: From Bench to Bedside in Treating Inflammatory Diseases

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 280, P. 116950 - 116950

Published: Oct. 11, 2024

Language: Английский

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Advances in the Diagnosis and Management of Inflammatory Bowel Disease (IBD)

Advanced Research in Gastroenterology & Hepatology, Journal Year: 2024, Volume and Issue: 20(4)

Published: July 5, 2024

journal of clinical gastroenterology is part the Juniper publishers which devoted to publish subject-specific articles focused on needs individual research communities across all areas biology and medicine.

Language: Английский

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