Diversity of Intercellular Communication Modes: A Cancer Biology Perspective DOI Creative Commons

Thanzeela Ebrahim,

Abdul Shukkur Ebrahim, Mustapha Kandouz

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(6), P. 495 - 495

Published: March 12, 2024

From the moment a cell is on path to malignant transformation, its interaction with other cells from microenvironment becomes altered. The flow of molecular information at heart cellular and systemic fate in tumors, various processes participate conveying key or certain cancer cells. For instance, loss tight junction molecules part signal sent so that they are no longer bound primary tumors thus free travel metastasize. Upon targeting single by therapeutic drug, gap junctions able communicate death by-standing discovery importance novel modes cell–cell communication such as different types extracellular vesicles tunneling nanotubes changing way scientists look these processes. However, all actively involved contexts same time recruited fulfill specific tasks? What does multiplicity mean for overall progression disease? Here, we extend an open invitation think about significance questions, rather than engage elusive attempt systematic repertory mechanisms play.

Language: Английский

Natural and synthetic nanovectors for cancer therapy DOI Creative Commons
Aziz Eftekhari, Carola Kryschi, David Pamies

et al.

Nanotheranostics, Journal Year: 2023, Volume and Issue: 7(3), P. 236 - 257

Published: Jan. 1, 2023

Nanomaterials have been extensively studied in cancer therapy as vectors that may improve drug delivery.Such not only bring numerous advantages such stability, biocompatibility, and cellular uptake but also shown to overcome some cancer-related resistances.Nanocarrier can deliver the more precisely specific organ while improving its pharmacokinetics, thereby avoiding secondary adverse effects on target tissue.Between these nanovectors, diverse material types be discerned, liposomes, dendrimers, carbon nanostructures, nanoparticles, nanowires, etc., each of which offers different opportunities for therapy.In this review, a broad spectrum nanovectors is analyzed application multimodal diagnostics terms mode action pharmacokinetics.Advantages inconveniences promising including gold SPIONs, semiconducting quantum dots, various phospholipid-based polymeric micelles, extracellular exome vesicles are summarized.The article concluded with future outlook field.

Language: Английский

Citations

112
Engineered extracellular vesicles and their mimetics for cancer immunotherapy DOI
Chunping Liu, Yichao Wang, Longmei Li

et al.

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 349, P. 679 - 698

Published: July 28, 2022

Language: Английский

Citations

105
Modification of immune cell-derived exosomes for enhanced cancer immunotherapy: current advances and therapeutic applications DOI Creative Commons
Inseong Jung, Sanghee Shin, Moon‐Chang Baek

et al.

Experimental & Molecular Medicine, Journal Year: 2024, Volume and Issue: 56(1), P. 19 - 31

Published: Jan. 4, 2024

Abstract Cancer immunotherapy has revolutionized the approach to cancer treatment of malignant tumors by harnessing body’s immune system selectively target cells. Despite remarkable advances, there are still challenges in achieving successful clinical responses. Recent evidence suggests that cell-derived exosomes modulate generate effective antitumor responses, making them a cutting-edge therapeutic strategy. However, natural limited application due their low drug delivery efficiency and insufficient capacity. Technological advancements have allowed exosome modifications magnify intrinsic functions, load different cargoes, preferentially tumor sites. These engineered exert potent effects great potential for immunotherapy. In this review, we describe ingenious modification strategies attain desired performance. Moreover, systematically summarize tumor-controlling properties innate adaptive immunity. Collectively, review provides comprehensive intuitive guide modified exosome-based approaches, offering valuable enhance optimize

Language: Английский

Citations

46
The biology and function of extracellular vesicles in immune response and immunity DOI
Raghu Kalluri

Immunity, Journal Year: 2024, Volume and Issue: 57(8), P. 1752 - 1768

Published: Aug. 1, 2024

Language: Английский

Citations

25
Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment DOI Creative Commons

Shiming Tan,

Yiqing Yang, Wenjuan Yang

et al.

Journal of Experimental & Clinical Cancer Research, Journal Year: 2023, Volume and Issue: 42(1)

Published: March 10, 2023

Metabolic reprogramming is one of the hallmarks cancer. As nutrients are scarce in tumor microenvironment (TME), cells adopt multiple metabolic adaptations to meet their growth requirements. not only present cells, but exosomal cargos mediates intercellular communication between and non-tumor TME, inducing remodeling create an outpost microvascular enrichment immune escape. Here, we highlight composition characteristics meanwhile summarize components corresponding sorting mode. Functionally, these cargos-mediated improves "soil" for metastasis. Moreover, discuss abnormal metabolism targeted by its potential antitumor therapy. In conclusion, this review updates current role TME enriches future application scenarios exosomes.

Language: Английский

Citations

41
Dendritic Cell-Derived Exosomes in Cancer Immunotherapy DOI Creative Commons

Shumin Luo,

Jing Chen, Fang Xu

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(8), P. 2070 - 2070

Published: Aug. 1, 2023

Exosomes are nanoscale vesicles released by diverse types of cells for complex intercellular communication. Numerous studies have shown that exosomes can regulate the body’s immune response to tumor and interfere with microenvironment (TME). In clinical trials on dendritic cell (DC)-based antitumor vaccines, no satisfactory results been achieved. However, recent suggested DC-derived (DEXs) may be superior DC-based vaccines in avoiding cell-mediated immunosuppression. DEXs contain multiple surface markers capture tumor-associated antigens (TAAs) promote cell-dependent rejection. These findings indicate necessity further development improvement DEX-based cell-free complement chemotherapy, radiotherapy, other immunotherapies. this review, we highlighted progress cancer immunotherapy, particularly concentrating landmark biological characterization DEXs, summarized their important role (TIME) application targeted immunotherapy. This review could enhance comprehension advances immunotherapy contribute elucidation how TIME, thereby providing a reference utilizing practice.

Language: Английский

Citations

35
Applications of nanotechnologies for miRNA-based cancer therapeutics: current advances and future perspectives DOI Creative Commons
Luis Alberto Bravo-Vázquez,

Andrea Méndez-García,

Alma L. Rodríguez

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11

Published: July 27, 2023

MicroRNAs (miRNAs) are short (18-25 nt), non-coding, widely conserved RNA molecules responsible for regulating gene expression via sequence-specific post-transcriptional mechanisms. Since the human miRNA transcriptome regulates of a number tumor suppressors and oncogenes, its dysregulation is associated with clinical onset different types cancer. Despite fact that numerous therapeutic approaches have been designed in recent years to treat cancer, complexity disease manifested by each patient has prevented development highly effective management strategy. However, over past decade, artificial miRNAs (i.e., anti-miRNAs mimics) shown promising results against various cancer types; nevertheless, their targeted delivery could be challenging. Notably, reports nanotechnology-based can greatly contribute hindering initiation processes, representing an innovative disease-modifying strategy Hence, this review, we evaluate recently developed drug systems therapeutics discuss potential challenges future directions, such as use plant-made nanoparticles, phytochemical-mediated modulation miRNAs, nanozymes.

Language: Английский

Citations

30
Nanoparticle-based immunoengineering strategies for enhancing cancer immunotherapy DOI

Bao-Toan Nguyen Dang,

Taeg Kyu Kwon, Sooyeun Lee

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 365, P. 773 - 800

Published: Dec. 14, 2023

Language: Английский

Citations

24
Defining tropism and activity of natural and engineered extracellular vesicles DOI Creative Commons
Wooil Choi,

Dong Jun Park,

Brian P. Eliceiri

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: April 10, 2024

Extracellular vesicles (EVs) have important roles as mediators of cell-to-cell communication, with physiological functions demonstrated in various

Language: Английский

Citations

9
Supramolecular peptide hydrogel epitope vaccine functionalized with CAR-T cells for the treatment of solid tumors DOI Creative Commons
Pengxiang Yang, Xiaomin Yao, Tian Xue

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101517 - 101517

Published: Jan. 22, 2025

Chimeric antigen receptor T-cell (CAR-T) therapy, which benefits from the perfect combination of gene editing techniques and antibody engineering, has shown outstanding clinical efficacy in hematological malignancies. Solid tumors present next challenge due to their extremely complicated microenvironment structural characteristics. Targeting efficiency persistence are currently bottleneck issues treatment CAR-T. Beyond drugs cytokines, biomaterials can modulate immune response, assisting adoptive CAR-T cells exerting function. In this study, a supramolecular peptide hydrogel epitope vaccine was designed serve as both preparation medium reservoir for cells. The self-assembling formed nanofiber scaffold through non-covalent interactions amphiphilic amino acids ion stabilizers. Firstly, complementary conjugated epitopes target sites were derived different extracellular domains HER2 protein, improved tumor spreading targeting efficiency. promoted cell proliferation, cytotoxic activity, lymphocyte subpopulation transformation. Furthermore, encapsulated (SPEV-CAR-T) induced endogenous humoral cellular responses sustained release cells, demonstrating superior anti-tumor effects an vivo mouse model. Most importantly, SPEV-CAR-T central memory systemic tissues, addressing poor single therapy. integration complementation active passive all-in-one system facilitated sequential succession exogenous responses, promoting persistent specific attack. showed therapeutic solid tumors.

Language: Английский

Citations

1