Cell Biochemistry and Function,
Journal Year:
2024,
Volume and Issue:
42(2)
Published: March 1, 2024
Abstract
Cerebral
ischemic
damage
is
prevalent
and
the
second
highest
cause
of
death
globally
across
patient
populations;
it
as
a
substantial
reason
morbidity
mortality.
Mesenchymal
stromal
cells
(MSCs)
have
garnered
significant
interest
potential
treatment
for
cerebral
damage,
shown
in
stroke,
because
their
potent
intrinsic
features,
which
include
self‐regeneration,
immunomodulation,
multi‐potency.
Additionally,
MSCs
are
easily
obtained,
isolated,
cultured.
Despite
this,
there
number
obstacles
that
hinder
effectiveness
MSC‐based
treatment,
such
adverse
microenvironmental
conditions
both
vivo
vitro.
To
overcome
these
obstacles,
naïve
MSC
has
undergone
modification
processes
to
enhance
its
innate
therapeutic
qualities.
Genetic
preconditioning
(with
medications,
growth
factors,
other
substances)
two
main
categories
into
techniques
can
be
separated.
This
field
advanced
significantly
still
attracting
attention
innovation.
We
examine
cutting‐edge
methods
preserving
even
improving
natural
biological
functions
relation
adhesion,
migration,
homing
target
site,
survival,
delayed
premature
senescence.
address
use
genetically
altered
stroke‐induced
damage.
Future
strategies
result
addressing
difficulties
associated
with
also
discussed.
Regenerative Biomaterials,
Journal Year:
2024,
Volume and Issue:
11
Published: Jan. 1, 2024
Abstract
Due
to
its
highly
insidious
and
rapid
progression,
deep
tissue
pressure
injury
(DTPI)
is
a
clinical
challenge.
Our
previous
study
found
that
DTPI
may
be
skeletal
muscle
dominated
by
macrophage
immune
dysfunction
due
excessive
iron
accumulation.
Decellularized
extracellular
matrix
(dECM)
hydrogel
promotes
repair.
However,
role
in
polarizing
macrophages
regulating
metabolism
remains
unclear.
Here,
porcine
dECM
was
prepared,
therapeutic
function
mechanism
repairing
were
investigated.
The
stimulus
of
toward
RAW264.7
cells
resulted
significantly
higher
percentage
CD206+
notably
decreased
intracellular
divalent
levels.
In
mice
model,
treatment
promoted
M1
M2
conversion,
improved
reduced
oxidative
stress
the
early
stage
DTPI.
remodeling
phase,
remarkably
enhanced
revascularization
accelerated
Furthermore,
immunomodulation
hydrogels
vivo
mainly
involved
P13k/Akt
signaling
pathway,
as
revealed
GO
KEGG
pathway
analysis,
which
ameliorate
deposition
promote
healing
findings
indicate
promising
repair,
inflammation
resolution
effectively
restoring
homeostasis
normalizing
metabolism.
Cell Biochemistry and Function,
Journal Year:
2024,
Volume and Issue:
42(2)
Published: March 1, 2024
Abstract
Cerebral
ischemic
damage
is
prevalent
and
the
second
highest
cause
of
death
globally
across
patient
populations;
it
as
a
substantial
reason
morbidity
mortality.
Mesenchymal
stromal
cells
(MSCs)
have
garnered
significant
interest
potential
treatment
for
cerebral
damage,
shown
in
stroke,
because
their
potent
intrinsic
features,
which
include
self‐regeneration,
immunomodulation,
multi‐potency.
Additionally,
MSCs
are
easily
obtained,
isolated,
cultured.
Despite
this,
there
number
obstacles
that
hinder
effectiveness
MSC‐based
treatment,
such
adverse
microenvironmental
conditions
both
vivo
vitro.
To
overcome
these
obstacles,
naïve
MSC
has
undergone
modification
processes
to
enhance
its
innate
therapeutic
qualities.
Genetic
preconditioning
(with
medications,
growth
factors,
other
substances)
two
main
categories
into
techniques
can
be
separated.
This
field
advanced
significantly
still
attracting
attention
innovation.
We
examine
cutting‐edge
methods
preserving
even
improving
natural
biological
functions
relation
adhesion,
migration,
homing
target
site,
survival,
delayed
premature
senescence.
address
use
genetically
altered
stroke‐induced
damage.
Future
strategies
result
addressing
difficulties
associated
with
also
discussed.
