Cognitive-Enhancing Effect of Marine Brown Algae-Derived Phenolics through S100B Inhibition and Antioxidant Activity in the Rat Model of Ischemic Stroke DOI Creative Commons
Jurairat Khongrum, Pratoomporn Yingthongchai, Suriya Tateing

et al.

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(10), P. 451 - 451

Published: Oct. 1, 2024

Cognitive impairments are frequently reported after ischemic strokes. Novel and effective treatments required. This study aimed to develop a functional ingredient obtained from marine algae determine the effect of extract on antioxidative stress, as well neuroprotective effects, in rat model MCAO-induced stroke. Among selected algal extracts, Sargassum polycystum displayed highest total phenolic content potential, was subsequently used evaluate cognitive function models The S. extract, administered at doses 100, 300, 500 mg/kg BW, significantly improved by enhancing performance Morris water maze novel object recognition tests. Biochemical changes revealed that providing increased activities SOD, CAT, GSH-Px 52.48%, 50.77%, 66.20%, respectively, decreased concentrations MDA 51.58% S100B 36.64% compared vehicle group. These findings suggest may mitigate impairment stroke reducing oxidative stress inhibiting expression, thus highlighting its potential for drugs nutraceuticals neuroprotection.

Language: Английский

Nanotechnology to Overcome Blood–Brain Barrier Permeability and Damage in Neurodegenerative Diseases DOI Creative Commons
Adriana Jiménez, Enrique Estudillo, Mara A. Guzmán‐Ruiz

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 281 - 281

Published: Feb. 20, 2025

The blood–brain barrier (BBB) is a critical structure that maintains brain homeostasis by selectively regulating nutrient influx and waste efflux. Not surprisingly, it often compromised in neurodegenerative diseases. In addition to its involvement these pathologies, the BBB also represents significant challenge for drug delivery into central nervous system. Nanoparticles (NPs) have been widely explored as carriers capable of overcoming this effectively transporting therapies brain. However, their potential directly address ameliorate dysfunction has received limited attention. review, we examine how NPs enhance across treat diseases explore emerging strategies restore integrity vital structure.

Language: Английский

Citations

1
Lipid Nanoparticles for Brain Tumor Theranostics: Challenges and Status DOI
Navneet Kaur Mattu,

Priyadarshi Gautam,

Dibyani Nanda

et al.

Bioconjugate Chemistry, Journal Year: 2024, Volume and Issue: 35(9), P. 1283 - 1299

Published: Aug. 29, 2024

Lipid nanoparticles have been recognized as a powerful weapon for delivering various imaging and therapeutic agents to the localized solid tumors, especially brain tumors individually or in combination. Promisingly, lipid-based nanosystems considered safe delivery systems which are even approved by Food Drug Administration (FDA) European Medicines Agency (EMA). One recent spotlight of lipid COVID-19 mRNA vaccines where play an important role effectively protecting desired cells. As now, successive progress nanocarriers, viz., nanoliposomes, nanoparticles, ionizable nanostructures, etc., with better biochemical biophysical stabilities, has noticed reported. Moreover, nanostructures versatile therapeutics platforms variety diseases due their biocompatibility, ability protect deliver site, reproducibility reliability. However, still face morphological changes upon vivo administration. These alter specific biological pathological response during personalized tumor theranostics. Second, nanomedicine faces major challenges zero premature leakage loaded cargo, long-term colloidal stability, off targeting. Herein, nanomedicines "theranostics" reviewed summarized considering aspects preclinical clinical studies. On other hand, engineering theranostics relevant advantages guidelines practice different also discussed. This review provides in-depth knowledge nanoparticle-based therapeutics.

Language: Английский

Citations

4
Capsicum in Clinical Biochemistry: Insights into its Role in Health and Disease DOI

Ayman Faris Faisal,

Yasser Fakri Mustafa

Indian Journal of Clinical Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Language: Английский

Citations

0
Study on the Relationship between Cerebral Blood Perfusion, Neuronal Cytokines and Cognitive Function in Patients with Alzheimer's Disease DOI Open Access

Hongjiang Lu,

Yuan Fang, Xuebo Chen

et al.

Actas Españolas de Psiquiatría, Journal Year: 2024, Volume and Issue: 52(3), P. 238 - 247

Published: June 5, 2024

Background: Alzheimer's disease (AD) is a common neurodegenerative disorder characterized by the progressive emergence of multiple cognitive deficits. Early diagnosis great significance for intervention and treatment AD. The objective this study to explore relationship between cerebral blood perfusion, neuronal cytokines function in patients with Methods: AD admitted 903 Hospital People's Liberation Army Joint Logistics Support Force from June 2020 January 2023 were retrospectively selected as objects, 65 healthy people who underwent physical examination during same period included control group. Subjects both groups 3.0 T magnetic resonance imaging (MRI) observe their perfusion parameters. level was assessed using Montreal Cognitive Assessment (MoCA). Venous collected groups, serum levels brain-derived factor (BDNF) glial cell-derived neurotrophic (GDNF) measured enzyme-linked immunosorbent assay (ELISA). correlation BDNF GDNF parameters MoCA score group analyzed Spearman analysis. Results: flow signal intensity left frontal lobe, right temporal parietal occipital lobe observation significantly lower than that (p < 0.001). visuospatial, executive functions, naming, attention, language function, abstract generalization ability, memory orientation, total scale scores those results analysis showed positively correlated patients, statistically significant 0.05). Conclusion: In people. Cerebral patients.

Language: Английский

Citations

1
Cognitive-Enhancing Effect of Marine Brown Algae-Derived Phenolics through S100B Inhibition and Antioxidant Activity in the Rat Model of Ischemic Stroke DOI Creative Commons
Jurairat Khongrum, Pratoomporn Yingthongchai, Suriya Tateing

et al.

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(10), P. 451 - 451

Published: Oct. 1, 2024

Cognitive impairments are frequently reported after ischemic strokes. Novel and effective treatments required. This study aimed to develop a functional ingredient obtained from marine algae determine the effect of extract on antioxidative stress, as well neuroprotective effects, in rat model MCAO-induced stroke. Among selected algal extracts, Sargassum polycystum displayed highest total phenolic content potential, was subsequently used evaluate cognitive function models The S. extract, administered at doses 100, 300, 500 mg/kg BW, significantly improved by enhancing performance Morris water maze novel object recognition tests. Biochemical changes revealed that providing increased activities SOD, CAT, GSH-Px 52.48%, 50.77%, 66.20%, respectively, decreased concentrations MDA 51.58% S100B 36.64% compared vehicle group. These findings suggest may mitigate impairment stroke reducing oxidative stress inhibiting expression, thus highlighting its potential for drugs nutraceuticals neuroprotection.

Language: Английский

Citations

0