Journal of Immunology Research,
Journal Year:
2023,
Volume and Issue:
2023, P. 1 - 15
Published: Aug. 4, 2023
Inflammation
is
a
physiological
mechanism
of
the
immune
response
and
has
an
important
role
in
maintaining
hematopoietic
cell
niche
bone
marrow.
During
this
process,
participation
molecules
produced
by
innate
immunity
cells
to
variety
pathogen-associated
molecular
patterns
damage-associated
observed.
However,
chronic
inflammation
intrinsically
associated
with
leukemogenesis,
as
it
induces
DNA
damage
stem
contributes
creation
preleukemic
clone.
Several
factors
influence
malignant
transformation
within
microenvironment,
inflammasomes
having
crucial
addition
acting
regulation
hematopoiesis
its
homeostasis.
Inflammasomes
are
intracellular
multimeric
complexes
responsible
for
maturation
secretion
proinflammatory
cytokines
interleukin-1β
interleukin-18
death
process
via
pyroptosis.
Therefore,
dysregulation
activation
these
may
be
factor
triggering
several
diseases,
including
leukemias,
been
subject
studies
area.
In
review,
we
summarized
current
knowledge
on
relationship
between
particular,
different
types
describe
potential
therapeutic
targets
directed
at
leukemic
context.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(8), P. 4430 - 4430
Published: April 17, 2024
Acute
myeloid
leukaemia
(AML)
management
remains
a
significant
challenge
in
oncology
due
to
its
low
survival
rates
and
high
post-treatment
relapse
rates,
mainly
attributed
treatment-resistant
leukaemic
stem
cells
(LSCs)
residing
bone
marrow
(BM)
niches.
This
review
offers
an
in-depth
analysis
of
AML
progression,
highlighting
the
pivotal
role
extracellular
vesicles
(EVs)
dynamic
remodelling
BM
niche
intercellular
communication.
We
explore
recent
advancements
elucidating
mechanisms
through
which
EVs
facilitate
complex
crosstalk,
effectively
promoting
hallmarks
drug
resistance.
Adopting
temporal
view,
we
chart
evolving
landscape
EV-mediated
interactions
within
niche,
underscoring
transformative
potential
these
insights
for
therapeutic
intervention.
Furthermore,
discusses
emerging
understanding
endothelial
cell
subsets'
impact
across
niches
shaping
disease
adding
another
layer
complexity
progression
treatment
highlight
cutting-edge
methodologies,
such
as
organ-on-chip
(OoC)
single-EV
technologies,
provide
unprecedented
into
AML-niche
human
setting.
Leveraging
accumulated
EV
signalling
reconfigure
pioneer
novel
approaches
decipher
networks
that
fuel
context
could
revolutionise
development
niche-targeted
therapy
eradication.
Current Obesity Reports,
Journal Year:
2023,
Volume and Issue:
13(1), P. 1 - 34
Published: Dec. 30, 2023
Abstract
Purpose
of
Review
To
examine
the
epidemiological
data
on
obesity
and
leukemia;
evaluate
effect
leukemia
outcomes
in
childhood
acute
lymphoblastic
(ALL)
survivors;
assess
potential
mechanisms
through
which
may
increase
risk
provide
effects
management
leukemia.
Preventive
(diet,
physical
exercise,
pharmacotherapy,
bariatric
surgery)
measures,
repurposing
drugs,
candidate
therapeutic
agents
targeting
oncogenic
pathways
insulin
resistance
as
well
challenges
COVID-19
pandemic
are
also
discussed.
Recent
Findings
Obesity
has
been
implicated
development
13
cancers,
such
breast,
endometrial,
colon,
renal,
esophageal
multiple
myeloma.
Leukemia
is
estimated
to
account
for
approximately
2.5%
3.1%
all
new
cancer
incidence
mortality,
respectively,
while
it
represents
most
frequent
children
younger
than
5
years.
Current
evidence
indicates
that
have
an
impact
Increased
birthweight
be
associated
with
worse
increased
mortality
leukemic
patients.
However,
there
several
limitations
meta-analyses
studies.
In
addition,
weight
gain
occur
a
substantial
number
ALL
survivors
majority
studies
documented
relapse
among
patients
obesity.
The
main
pathophysiological
linking
include
bone
marrow
adipose
tissue;
hormones
insulin-like
growth
factor
system
sex
hormones;
pro-inflammatory
cytokines,
IL-6
TNF-α;
adipocytokines,
adiponectin,
leptin,
resistin,
visfatin;
dyslipidemia
lipid
signaling;
chronic
low-grade
inflammation
oxidative
stress;
other
emerging
mechanisms.
Summary
leukemia,
being
only
known
factors
could
prevented
or
modified
loss,
healthy
diet,
exercise.
Pharmacological
interventions,
drugs
used
cardiometabolic
comorbidities,
surgery
recommended
obesity-related
prevention.
Journal of Extracellular Vesicles,
Journal Year:
2024,
Volume and Issue:
13(3)
Published: March 1, 2024
Abstract
Small
extracellular
vesicles
(sEVs)
released
by
acute
myeloid
leukaemia
(AML)
cells
have
been
reported
to
influence
the
trilineage
differentiation
of
bone
marrow‐derived
mesenchymal
stem
(BM‐MSCs).
However,
it
remains
elusive
which
biological
cargo
from
AML‐sEVs
is
responsible
for
this
effect.
In
study,
sEVs
were
isolated
cell‐conditioned
media
and
blood
plasma
using
size‐exclusion
chromatography
ultrafiltration
characterized
according
MISEV2018
guidelines.
Our
results
demonstrated
that
increased
proliferation
BM‐MSCs.
Conversely,
key
proteins
are
important
normal
haematopoiesis
downregulated
in
Additionally,
we
revealed
significantly
reduced
BM‐MSCs
osteoblasts
without
affecting
adipogenic
or
chondrogenic
differentiation.
Next,
LC‐MS/MS
proteomics
elucidated
various
proteins,
including
Y‐box‐binding
protein
1
(YBX1),
upregulated
both
treated
with
AML‐sEVs.
Clinically
relevant,
found
YBX1
considerably
most
paediatric
AML
patient‐derived
compared
healthy
controls.
Interestingly,
after
downregulation
remarkably
rescued
osteoblastic
Altogether,
our
data
demonstrate
first
time
containing
one
players
disrupt
function
marrow
microenvironment
reducing
osteogenic
Discover Oncology,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: March 12, 2025
Clinical
management
of
acute
myeloid
leukemia
(AML)
poses
significant
challenges
due
to
its
poor
prognosis
and
heterogeneous
nature.
Discovering
new
biomarkers
is
crucial
for
improving
risk
assessment
customizing
treatment
approaches.
While
leukocyte-specific
transcript
1
(LST1)
implicated
in
inflammation
immune
regulation,
function
AML
remains
ambiguous.
In
this
investigation,
we
conduct
a
comprehensive
investigation
into
LST1
expression
profiles,
clinical
implications,
functional
pathways,
interactions
AML,
leveraging
multi-omics
data
experimental
validations.
Our
examination
shows
increased
levels
when
compared
regular
hematopoietic
tissues,
discovery
validated
by
RT-qPCR
Western
blot
analyses
separate
group.
Elevated
correlate
with
distinct
clinicopathological
features,
including
white
blood
cell
counts,
non-M3
FAB
subtype,
intermediate/poor
cytogenetic
risk.
Importantly,
heightened
predict
unfavorable
overall
survival
outcomes
across
various
subgroups,
independently
age
We
develop
an
integrative
nomogram
incorporating
expression,
demonstrating
robust
prognostic
efficacy
patient
survival.
Transcriptomic
profiling
identifies
275
differentially
expressed
genes
between
LST1-high
-low
cases,
enriched
cytokine
signaling,
modulation,
adhesion,
oncogenic
pathways.
Furthermore,
exhibits
associations
the
infiltration
diverse
subsets
within
microenvironment,
particularly
cells
regulatory
T
(Tregs).
conclusion,
our
study
establishes
as
novel
indicator
immunological
relevance
emphasizing
potential
therapeutic
implications.
Further
mechanistic
elucidation
pathogenesis
translation.
Seminars in Oncology,
Journal Year:
2025,
Volume and Issue:
52(3), P. 152347 - 152347
Published: May 5, 2025
Acute
myeloid
leukemia
(AML)
is
a
hematological
malignancy
representing
very
rapid,
uncontrolled
growth
of
precursors
in
the
BM
and
peripheral
circulation.
Studies
on
AML
have
highlighted
crucial
role
IFN-γ
therapy
immune
surveillance,
both
promotive
inhibitory
effects
leukemic
cells,
regulation
tumor
microenvironment.
However,
there
need
for
comprehensive
understanding
dual
AML.
Thus,
this
review
aimed
to
assess
Literature
searches
were
conducted
Pub
Med,
Google
Scholar,
direct
Search.
The
data
was
presented
tables
figures,
with
findings
summarized
through
narrative
synthesis.
Depending
circumstances
stage
disease
shows
two
different
activities
patients.
First,
enhances
NK
cells
CD8+T
lymphocyte
functions,
which
collectively
evoke
antileukemic
immunity.
Another
promising
effect
includes
differentiation
thereby
possibly
reducing
severity
leukemia.
prolonged
exposure
can
activate
Treg
immunological
checkpoints,
help
evade
surveillance
encounter
an
immunosuppressive
environment.
Our
highlights
IFN-γ's
critical
complex
interplay
between
system
pathogenesis.
Its
inhibiting
promoting
processes
has
been
highlighted.
future
pre-clinical
clinical
studies
should
focus
specific
mechanisms
by
impacts
progression
treatment
outcomes,
goal
achieving
curative
results
