Multi-omics in Study of Oral Microbiome DOI

Duy Ha Nguyen,

Dinh‐Toi Chu

Published: Jan. 1, 2024

Dental health and disease correlate with the ability of oral microbes to compose perform their functions, along interactions between constituent microorganisms inside microbiota mouth. The mouth cavity is a very active microbial environment ecosystem several substrates microenvironments housing various populations. This dynamic ecology promotes dysbiosis as well emergence dental periodontal disorders. Biomarker techniques for composition evaluation that focus on gene or common area certain sex bacteria displaying super variable sequence variations are examples sequencing-reliant tactics determining assessment. These hypervariable genes areas allow recognition community members, but they may be limited in distinguish phylogenetically similar species strains supply no data number functional present. Multi-omics analytical approaches have proven superior research gut components association human illness. We present an overview such omics technologies this study, emphasis strategies integrating them across many layers omics. In comparison single-omics studies, multi-omics helps researchers better understand information flow underlying sickness.

Language: Английский

Causal relationship between 14 micronutrients and chronic periodontitis: a Mendelian randomization study DOI Open Access
Zongliang Yu, Yang Yang, Zongliang Yu

et al.

Australian Dental Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Chronic periodontitis is one of the most common inflammatory diseases worldwide. Micronutrients play a significant impact on health and periodontal disease progression. However, there still lack conclusive studies confirming causal association micronutrients with chronic periodontitis.

Language: Английский

Citations

0
Salivary microbiota and metabolic phenotype of patients with recurrent aphthous ulcers DOI
Yunmei Dong,

Fangzhi Lou,

Yan Li

et al.

Oral Diseases, Journal Year: 2024, Volume and Issue: 30(7), P. 4412 - 4425

Published: Jan. 2, 2024

Recurrent aphthous ulcer (RAU) is a prevalent oral mucosal disease, affecting around 20% of the global population. It can greatly impair quality life for affected individuals. However, exact etiology RAU remains unknown.

Language: Английский

Citations

3
Exploring the role of oral bacteria in oral cancer: a narrative review DOI Creative Commons

Hassan Mivehchi,

Aisan Eskandari-Yaghbastlo,

Parnian Pour Bahrami

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 26, 2025

A growing body of research indicates that a wide range cancer types may correlate with human microbiome components. On the other hand, little is known about potential contribution oral microbiota to cancer. However, some components can stimulate different tumorigenic processes associated development In this line, two prevalent infections, Porphyromonas gingivalis, and Fusobacterium nucleatum increase tumor growth. The impact course illness through direct interactions major modifications toxicity responsiveness kinds therapy. Recent has demonstrated relationship between specific phylogenetic groupings results immunotherapy treatment for particular types. Conversely, there been recent upsurge in interest possibility using microbes treat At moment, species, such as Salmonella typhimurium Clostridium spp., are being explored possible vectors. Thus, understanding these microbial highlights importance maintaining healthy preventing cancers. From perspective, review will discuss role on cancers their application treatment/improvement.

Language: Английский

Citations

0
Illuminating the oral microbiome and its host interactions: recent advancements in omics and bioinformatics technologies in the context of oral microbiome research DOI Creative Commons
Jonathon L. Baker

FEMS Microbiology Reviews, Journal Year: 2023, Volume and Issue: 47(5)

Published: Sept. 1, 2023

Abstract The oral microbiota has an enormous impact on human health, with dysbiosis now linked to many and systemic diseases. Recent advancements in sequencing, mass spectrometry, bioinformatics, computational biology, machine learning are revolutionizing microbiome research, enabling analysis at unprecedented scale level of resolution using omics approaches. This review contains a comprehensive perspective the current state-of-the-art tools available perform genomics, metagenomics, phylogenomics, pangenomics, transcriptomics, proteomics, metabolomics, lipidomics, multi-omics (all) microbiomes, then provides examples how techniques have been applied research microbiome, specifically. Key findings these studies remaining challenges for field highlighted. Although methods discussed here placed context their contributions specifically, they pertinent study any intended audience this includes researchers would simply like get introduction microbial and/or update latest methods. Continued approaches is crucial will lead dramatic improvements longevity, quality life.

Language: Английский

Citations

9
Comprehensive analysis of the oral microbiota and metabolome change in patients of burning mouth syndrome with psychiatric symptoms DOI Creative Commons

Shihong Luo,

Fangzhi Lou,

Yan Li

et al.

Journal of Oral Microbiology, Journal Year: 2024, Volume and Issue: 16(1)

Published: June 3, 2024

Background Burning mouth syndrome (BMS) is a chronic idiopathic facial pain with intraoral burning or dysesthesia. BMS patients regularly suffer from anxiety/depression, and the association of psychiatric symptoms has received considerable attention in recent years. The aims this study were to investigate potential interplay between BMS.

Language: Английский

Citations

2
Microbiota signature of oral chronic graft-<i>versus</i>-host disease 6+ years after transplantation DOI Creative Commons
Armin Rashidi, Lang Liang, Ted Gooley

et al.

Haematologica, Journal Year: 2024, Volume and Issue: unknown

Published: July 11, 2024

Not available.

Language: Английский

Citations

1
Oral microbiome, periodontal disease and systemic bone-related diseases in the era of homeostatic medicine DOI Creative Commons

W L Hu,

Shuoling Chen,

Xianghui Zou

et al.

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 1, 2024

Homeostasis is a state of self-regulation and dynamic equilibrium, maintaining the good physiological functions each system in living organisms. In oral cavity, interaction between host microbiome forms microbial homeostasis. Physiological bone remodeling renewal can occur under maintenance The imbalance homeostasis key mechanism leading to occurrence systemic bone-related diseases. Considering importance homeostasis, it still lacks complete understanding relationship microbiome, periodontal disease

Language: Английский

Citations

1
Alterations of oral microbiome and metabolic signatures and their interaction in oral lichen planus DOI Creative Commons
Yan Li,

Jingyi Xu,

Fangzhi Lou

et al.

Journal of Oral Microbiology, Journal Year: 2024, Volume and Issue: 16(1)

Published: Oct. 30, 2024

Oral lichen planus (OLP) is a chronic oral mucosal inflammatory disease with risk of becoming malignant. Emerging evidence suggests that microbial imbalance plays an important role in the development OLP. However, association between microbiota and metabolic features OLP still unclear.

Language: Английский

Citations

0
Multi-omics in Study of Oral Microbiome DOI

Duy Ha Nguyen,

Dinh‐Toi Chu

Published: Jan. 1, 2024

Dental health and disease correlate with the ability of oral microbes to compose perform their functions, along interactions between constituent microorganisms inside microbiota mouth. The mouth cavity is a very active microbial environment ecosystem several substrates microenvironments housing various populations. This dynamic ecology promotes dysbiosis as well emergence dental periodontal disorders. Biomarker techniques for composition evaluation that focus on gene or common area certain sex bacteria displaying super variable sequence variations are examples sequencing-reliant tactics determining assessment. These hypervariable genes areas allow recognition community members, but they may be limited in distinguish phylogenetically similar species strains supply no data number functional present. Multi-omics analytical approaches have proven superior research gut components association human illness. We present an overview such omics technologies this study, emphasis strategies integrating them across many layers omics. In comparison single-omics studies, multi-omics helps researchers better understand information flow underlying sickness.

Language: Английский

Citations

0