Mechanisms of gut homeostasis regulating Th17/Treg cell balance in PMOP DOI Creative Commons
Qi Peng, Runbo Xie,

Hao Liu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 13, 2024

Postmenopausal osteoporosis (PMOP) is a metabolic bone disease driven by estrogen deficiency, primarily manifesting as reduced mass and heightened fracture risk. Its development intricately linked to the balance between Th17 Treg cells. Recent studies have highlighted significant role of gut homeostasis in PMOP. The microbiota profoundly impacts health modulating host’s immune system, pathways, endocrine functions. In particular, regulation cell plays pivotal onset progression cells secrete pro-inflammatory cytokines that stimulate osteoclast activity, accelerating resorption, while counteract this process through anti-inflammatory mechanisms, preserving mass. its metabolites can influence Th17/Treg equilibrium, thereby metabolism. Furthermore, integrity barrier critical for systemic stability, disruption lead dysregulation imbalances. Thus, targeting restore offers novel therapeutic avenue prevention treatment

Language: Английский

The causal impact of saturated fatty acids on rheumatoid arthritis: a bidirectional Mendelian randomisation study DOI Creative Commons

Xiaoling Yao,

Yuzheng Yang,

Zong Jiang

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Feb. 12, 2024

Objective The causal relationship between saturated fatty acids (SFAs) and rheumatoid arthritis (RA) remains poorly understood. This study aimed to determine whether SFAs are causally related RA using Mendelian randomisation (MR) analyses. Methods Genome-wide association (GWAS) summary data for (ukb-d-M13_RHEUMA) (met-d-SFA) were obtained from the Integrative Epidemiology Unit OpenGWAS database. A bidirectional MR analysis was performed a suite of algorithms, namely MR-Egger, weighted median, simple mode, inverse-variance (IVW) all integrated “MR” function. robustness findings further evaluated through sensitivity analyses, including heterogeneity, horizontal pleiotropy, leave-one-out tests. Results IVW algorithm in forward indicated link ( p = 0.025), identifying as risk factor (odds ratio 1.001). Sensitivity analyses no significant or severe bias, reinforcing credibility results. However, reverse revealed that does not affect SFA levels 0.195), this finding supported by corresponding Conclusion substantiate positive effect on incidence analysis, thereby offering consequential direction future research diagnosis treatment RA.

Language: Английский

Citations

4
Intestinal permeability disturbances: causes, diseases and therapy DOI Creative Commons
Barbara Macura, Aneta Kiecka, Marian Szczepanik

et al.

Clinical and Experimental Medicine, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 28, 2024

Language: Английский

Citations

4
Effects of different acupuncture and moxibustion methods on knee joint cartilage morphology, serum inflammatory factors, and intestinal flora in rats with knee osteoarthritis DOI
Qi Dong, Ye-Juan Jia, Lingling Qin

et al.

Journal of Acupuncture and Tuina Science, Journal Year: 2025, Volume and Issue: 23(1), P. 22 - 35

Published: Feb. 1, 2025

Language: Английский

Citations

0
Butyrate (short-chain fatty acid) alleviates lipopolysaccharide-binding proteins and improves physical function in knee osteoarthritis patients DOI
Asima Karim, Haroon Ahmed Khan, Firdos Ahmad

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 307, P. 142017 - 142017

Published: March 11, 2025

Language: Английский

Citations

0
Gut microbial metabolites as a convergence point between autoimmunity and solid tumors DOI Creative Commons

Anu Shibi Anilkumar,

Sheena Mariam Thomas, Ramakrishnan Veerabathiran

et al.

Gut Microbes Reports, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12

Published: March 12, 2025

Language: Английский

Citations

0
The Interaction Between Microbiota and Stem Cells on Progression of Osteoarthritis and Engineered Stem Cell for Enhancing Osteoarthritis Treatment DOI Creative Commons
Sidan Wang,

Haotian Fu,

Zheng Xu

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 3219 - 3234

Published: March 1, 2025

Osteoarthritis (OA) is characterized by the degeneration of articular cartilage caused several factors which novel most trends include microbiota. Specific microbiota and role in development OA less clear. The presumed to influence occurrence progression mainly via immune modulation. In recent years, bone marrow mesenchymal stem cells (MSCs) have shown great potential for treatment OA, however, therapeutic efficiency has been seriously affected harsh microenvironment joint cavity. At present, many strategies used enhance function MSCs, among them, engineering are a promising method. Therefore, this review focuses on latest research how affects cell repair, use engineered MSCs OA. addition, can exosomes as strategy treating Our provides comprehensive perspective therapy

Language: Английский

Citations

0
Restoring immune tolerance in pre-RA: immunometabolic dialogue between gut microbiota and regulatory T cells DOI Creative Commons
Anqi Gao,

Ruihe Wu,

Yanfei Mu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 20, 2025

Rheumatoid arthritis (RA) is a complex chronic autoimmune disease that remains incurable for most patients. With advances in our understanding of the disease’s natural history, concept pre-RA has emerged as window opportunity to intervene before irreversible joint damage occurs. Numerous studies have indicated key step driving autoimmunity early lies at an extra-articular site, which closely related regulatory T (Treg) cell-established immune tolerance gut microbiota. The intricate immunometabolic crosstalk between Treg cells and microbiota beginning be understood, with re-recognition metabolic sensors recent years. In future, deciphering their dialogue may help elucidate underlying mechanisms pre-RA. Identifying novel biological pathways stage will bring insights into restoring tolerance, thereby potentially curing or preventing onset RA.

Language: Английский

Citations

0
MTX-induced gastrointestinal reactions in RA: Prevotella enrichment, gut dysbiosis, and PI3K/Akt/Ras/AMPK pathways DOI

Rui-xue Duo,

Yining Wang,

Qiaoqiao Ma

et al.

Clinical Rheumatology, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Language: Английский

Citations

0
Persea americana Peel: A Promising Source of Nutraceutical for the Mitigation of Cardiovascular Risk in Arthritic Rats Through the Gut–Joint Axis DOI Creative Commons
Doha A. Mohamed, Asmaa Ramadan, Hoda B. Mabrok

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(4), P. 590 - 590

Published: April 16, 2025

Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterized by the inflammation of synovial fluid. The incidence cardiovascular diseases (CVDs) increasing in RA patients. This research first report to investigate anti-arthritic effect avocado peel nutraceutical (APN) and its potential mitigating risk associated with RA. antioxidant activity phytochemical composition APN were assessed. interaction APN’s active compounds protein tyrosine phosphatase non-receptor type 22 (PTPN22) was studied using molecular docking. impact on plasma lipid profile, oxidative markers, indices coronary atherogenicity as CVD markers evaluated. gene expression COX-2, IL-6, IL-1β, IL-10, TNF-α liver spleen tissues measured. rat gut microbiota profile investigated 16S rRNA amplicon sequencing. exhibited high activity, low thrombogenicity indices, ratio hypocholesterolemic hypercholesterolemic fatty acids indicating cardioprotective potential. administration led reduction stress dyslipidemia, markers. downregulated genes, while IL-10 significantly upregulated spleen. Treatment favorable restoring eubiosis modulating RA-associated bacterial taxa linked impaired immune function cardiometabolic diseases. In docking, β-amyrin ellagic acid showed highest binding affinity for PTPN22. may represent promising approach ameliorating present results will be offering foundation future in-depth nutraceuticals from agriculture by-products. Additionally, they supporting public health policies aimed at preventing controlling rheumatoid arthritis.

Language: Английский

Citations

0
Inflammatory bowel disease and rheumatoid arthritis share a common genetic structure DOI Creative Commons

Guoling Cao,

Qinghua Luo,

Yunxiang Wu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: June 13, 2024

Background The comorbidity rate of inflammatory bowel disease (IBD) and rheumatoid arthritis (RA) is high; nevertheless, the reasons behind this high remain unclear. Their similar genetic makeup probably contributes to comorbidity. Methods Based on data obtained from genome-wide association study IBD RA, we first assessed an overall by performing linkage disequilibrium score regression (LDSC) analysis. Further, a local correlation analysis was performed estimating heritability in summary statistics. Next, causality between two diseases analyzed two-sample Mendelian randomization (MR). A overlap conditional/conjoint false discovery (cond/conjFDR) method.LDSC with specific expression gene identify related tissues diseases. Finally, GWAS multi-trait (MTAG) also carried out. Results RA are correlated at genomic level, both locally. MR results suggested that induced RA. We identified 20 shared loci basis conjFDR <0.01. Additionally, tissues, namely spleen small intestine terminal ileum, which were commonly associated Conclusion Herein, proved presence polygenic provided new insights into architecture mechanisms underlying these

Language: Английский

Citations

3