Targeting tumor-associated macrophages for successful immunotherapy of ovarian carcinoma

Journal for ImmunoTherapy of Cancer, Journal Year: 2023, Volume and Issue: 11(2), P. e005968 - e005968

Published: Feb. 1, 2023

Epithelial ovarian cancer (EOC) is among the top five causes of cancer-related death in women, largely reflecting early, prediagnosis dissemination malignant cells to peritoneum. Despite improvements medical therapies, particularly with implementation novel drugs targeting homologous recombination deficiency, survival rates patients EOC remain low. Unlike other neoplasms, remains relatively insensitive immune checkpoint inhibitors, which correlated a tumor microenvironment (TME) characterized by poor infiltration and active immunosuppression dominated components tumor-promoting properties, especially tumor-associated macrophages (TAMs). In recent years, TAMs have attracted interest as potential therapeutic targets seeking reverse TME enhance clinical efficacy immunotherapy. Here, we review key biological features that affect progression their relevance for treating EOC. We focus on therapies might modulate recruitment, polarization, survival, functional properties can be harnessed develop superior combinatorial regimens immunotherapy care

Language: Английский

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Tertiary lymphoid structures in diseases: immune mechanisms and therapeutic advances

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Aug. 28, 2024

Tertiary lymphoid structures (TLSs) are defined as aggregates formed in non-hematopoietic organs under pathological conditions. Similar to secondary (SLOs), the formation of TLSs relies on interaction between tissue inducer (LTi) cells and organizer (LTo) cells, involving multiple cytokines. Heterogeneity is a distinguishing feature TLSs, which may lead differences their functions. Growing evidence suggests that associated with various diseases, such cancers, autoimmune transplant rejection, chronic inflammation, infection, even ageing. However, detailed mechanisms behind these clinical associations not yet fully understood. The by TLS maturation localization affect immune function also unclear. Therefore, it necessary enhance understanding development at cellular molecular level, allow us utilize them improve microenvironment. In this review, we delve into composition, mechanism, potential therapeutic applications TLSs. Furthermore, discuss implications role markers response prognosis. Finally, summarize methods for detecting targeting Overall, provide comprehensive aim develop more effective strategies.

Language: Английский

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Differentiation of Cytotoxic CD8⁺ T Cell Subsets Under Tumor Progression: Can CD69 Be a New Therapeutic Target?

Cancer Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Tumor-specific CD8+ T cells play a pivotal role in anti-tumor immunity. Here, we review the heterogeneity of cell subsets during tumor progression. While both acute and chronic viral infections induce distinct responses, responses are also observed development. Chronic immune have traditionally been considered to represent dysfunctional state cells, whereas identification TCF1+ stem-like has highlighted their importance During progression, differentiate into cytotoxic Tim-3+ terminally differentiated through mechanisms that remain largely unknown. We recently identified CD69 as an important regulator showed blocking function, either administration anti-CD69 antibody (Ab) or genetic knockout, enhanced generation tumor-draining lymph nodes (TDLNs) microenvironment (TME), thereby enhancing response. These findings suggest is attractive therapeutic target controls

Language: Английский

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Recent advances in understanding the immune microenvironment in ovarian cancer

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: June 5, 2024

The occurrence of ovarian cancer (OC) is a major factor in women’s mortality rates. Despite progress medical treatments, like new drugs targeting homologous recombination deficiency, survival rates for OC patients are still not ideal. tumor microenvironment (TME) includes cells, fibroblasts linked to (CAFs), immune-inflammatory and the substances these cells secrete, along with non-cellular components extracellular matrix (ECM). First, TME mainly plays role inhibiting growth protecting normal cell survival. As tumors progress, gradually becomes place promote progression. Immune have attracted much attention as targets immunotherapy. checkpoint inhibitor (ICI) therapy has potential regulate TME, suppressing factors that facilitate advancement, reactivating immune managing growth, extending advanced cancer. This review presents an outline current studies on distinct cellular elements within detailing their main functions possible signaling pathways. Additionally, we examine immunotherapy rechallenge OC, specific emphasis biological reasons behind resistance ICIs.

Language: Английский

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Revisiting the CXCL13/CXCR5 Axis in the Tumor Microenvironment in the Era of Single-cell Omics: Implications for Immunotherapy

Cancer Letters, Journal Year: 2024, Volume and Issue: unknown, P. 217278 - 217278

Published: Sept. 1, 2024

Language: Английский

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Tumor-Infiltrating B Cells and Tissue-Resident Memory T Cells as Prognostic Indicators in Brain Metastases Derived from Gastrointestinal Cancers

Cancers, Journal Year: 2024, Volume and Issue: 16(22), P. 3765 - 3765

Published: Nov. 8, 2024

Tumor-infiltrating B cells (TIBs) and tissue-resident memory T (TRMs) play significant roles in antitumor immunity. However, their prognostic relevance brain metastases (BMs) derived from gastrointestinal (GI) cancers remains unclear. This study aimed to investigate the significance of TIBs TRMs GI cancer-derived BMs (GIBMs).

Language: Английский

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