Interactions between Malassezia and New Therapeutic Agents in Atopic Dermatitis Affecting Skin Barrier and Inflammation in Recombinant Human Epidermis Model

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(7), P. 6171 - 6171

Published: March 24, 2023

Several studies have reported the pathogenic role of Malassezia in atopic dermatitis (AD); significance Malassezia's influence on AD needs to be further investigated. Dupilumab, a monoclonal antibody anti-Interleukin (IL) 4Rα, and ruxolitinib, Janus kinase (JAK)1/2 inhibitor, are first approved biologics inhibitors widely used for treatment. In this study, we aimed investigate how Restricta (M. restricta) affects skin barrier inflammation interacts with therapeutic agents ruxolitinib anti-IL4Rα. To induce an vitro model, reconstructed human epidermis (RHE) was treated IL-4 IL-13. M. restricta inoculated surface RHE, anti-IL4Rα or supplemented model lesions. Histological molecular analyses were performed. Skin ceramide-related molecules downregulated by reverted ruxolitinib. Antimicrobial peptides, VEGF, Th2-related, JAK/STAT pathway upregulated suppressed These findings show that aggravated function Th2 decreased efficacy

Language: Английский

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Pathogenesis of Inflammation in Skin Disease: From Molecular Mechanisms to Pathology

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 10152 - 10152

Published: Sept. 21, 2024

Many skin diseases begin with inflammatory changes on a molecular level. To develop more thorough understanding of pathology and to identify new targets for therapeutic advancements, mechanisms inflammation in the context disease should be studied. Current research efforts better understand have focused examining role processes at several stages response such as dysregulation innate immunity sensors, disruption both transcriptional post-transcriptional regulation, crosstalk between immune neuronal (neuro-immune crosstalk). This review seeks summarize recent developments our highlight opportunities advancements. With focus publications within past 5 years (2019–2024), databases PubMed EBSCOhost were used search peer-reviewed papers regarding disease. Several themes interest determined through extensive included based their relative representation current potential. psoriasis, atopic dermatitis, hidradenitis suppurativa, scleroderma described paper demonstrate widespread influence

Language: Английский

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The role and mechanisms of mesenchymal stem cells regulating macrophage plasticity in spinal cord injury

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 168, P. 115632 - 115632

Published: Oct. 6, 2023

Spinal Cord Injury (SCI) is a devastating neurological disorder comprising primary mechanical injury and secondary inflammatory response-mediated for which an effective treatment still unavailable. It well known that responses are significant cause of difficulties in recovery. An immune imbalance between M1/M2 macrophages at the sites involved developing progressing response. Recently, Mesenchymal Stem Cells (MSCs) have shown therapeutic potential tissue engineering regenerative medicine due to their multidirectional differentiation immunomodulatory properties. Accumulating evidence shows MSCs can regulate balance macrophage polarization, suppress downstream responses, facilitate repair regeneration, improve prognosis SCI. This article briefly overviews impact on SCI repair. discusses mechanisms by plasticity, including paracrine action, release exosomes apoptotic bodies, metabolic reprogramming. Additionally, summarizes relevant signaling pathways polarization.

Language: Английский

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SOCS1 and SOCS3 as key checkpoint molecules in the immune responses associated to skin inflammation and malignant transformation

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: June 21, 2024

SOCS are a family of negative inhibitors the molecular cascades induced by cytokines, growth factors and hormones. At level, proteins inhibit kinase activity specific sets receptor-associated Janus Activated Kinases (JAKs), thereby suppressing propagation intracellular signals. Of eight known members, SOCS1 SOCS3 JAKs mainly cytokines can play key roles in regulation inflammatory immune responses. most well-characterized members skin diseases, where their inhibitory on cytokine activated consequent anti-inflammatory action has been widely investigated epidermal keratinocytes. Structurally, share presence N-terminal domain containing region (KIR) motif able to act as pseudo-substrate for JAK its activity. During last decades, design employment SOCS3-derived peptides mimicking KIR domains experimental models dermatoses definitively established strong ameliorative impact inhibition Herein, we discuss importance findings collected past function responses associated immune-mediated diseases malignancies, development inhibitor drugs. Among them, different have introduced clinical practice treatment atopic dermatitis psoriasis, others being like alopecia areata vitiligo.

Language: Английский

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A real-world study to assess the disease control of moderate to severe atopic dermatitis in patients receiving dupilumab therapy, with atopic dermatitis control tool in Gulf countries

Journal of Dermatological Treatment, Journal Year: 2025, Volume and Issue: 36(1)

Published: Jan. 6, 2025

Purpose/aim of the study There is limited real-world evidence regarding effectiveness and safety dupilumab in Gulf countries. The aimed to evaluate atopic dermatitis (AD) disease control adult adolescent patients (≥12 years) treated with

Language: Английский

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