Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 10, 2024
Abstract
Background:
The
COVID-19
pandemic
have
impacts
on
the
prevalence
of
other
pathogens
and
people’s
social
lifestyle.
This
study
aimed
to
compare
pathogen,
allergen
micronutrient
characteristics
pediatric
inpatients
with
pneumonia
prior
during
in
a
large
tertiary
hospital
Shanghai,
China.
Methods:
Patients
admitted
Department
Pediatric
Pulmonology
Xinhua
Hospital
between
March-August
2019
2020
were
recruited.
And
clinical
patients
compared
those
2020.
Results:
Hospitalizations
for
decreased
by
74%
after
pandemic.
For
pathogens,
virus,
mycoplasma
pneumoniae
(MP)
mixed
infection
rates
all
much
lower
than
(
P
<
0.01).
Regarding
allergens,
2019,
positive
house
dust
mite,
shrimp
crab
significantly
higher
micronutrients,
levels
vitamin
B2,
B6,
C
25-hydroxyvitamin
D
(25(OH)D)
observed
be
0.05).
participants,
longer
stay
(OR
=
1.521,
0.000),
milk
allergy
6.552,
0.033)
calcium
(Ca)
insufficiency
12.048,
0.019)
identified
as
high-risk
factors
severe
multivariate
analysis.
Conclusions:
number
children
hospitalized
incidence
common
pathogen
infections
both
reduced,
that
status
also
changed
outbreak
Current Nutrition Reports,
Journal Year:
2025,
Volume and Issue:
14(1)
Published: Feb. 1, 2025
The
COVID-19
pandemic,
caused
by
SARS-CoV-2,
has
highlighted
the
potential
role
of
nutrition
in
modifying
disease
susceptibility
and
severity.
This
review
aims
to
systematically
evaluate
current
evidence
on
associations
between
dietary
patterns,
assessed
using
diet
quality
scores
(DQS),
severity
outcomes.
A
comprehensive
literature
search
identified
15
studies
across
diverse
populations.
Prospective
cohort
generally
found
higher
associated
with
lower
infection
rates.
Case-control
consistently
showed
reduced
odds
severe
illness
adherence
anti-inflammatory
particularly
Mediterranean
diet.
Cross-sectional
data
revealed
DQS
symptom
burden
improved
prognostic
biomarkers.
An
ecological
study
demonstrated
inverse
relationships
national-level
caseloads.
Mediterranean,
Dietary
Approaches
Stop
Hypertension
(DASH),
plant-based
were
notably
predictive
favourable
outcomes,
even
after
adjusting
for
confounders.
Conversely,
consumption
processed
foods
high
saturated
fats,
sugars,
additives
was
linked
increased
complications.
Despite
these
findings,
research
gaps
remain,
including
impacts
specific
components,
effect
modifiers
populations,
establishing
causality
through
interventional
trials.
highlights
observational
supporting
integration
optimal
into
pandemic
preparedness
strategies.
Further
is
needed
strengthen
findings
inform
evidence-based
recommendations
prevention
management.
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(9), P. 1469 - 1469
Published: April 26, 2025
The
function
of
the
immune
system
is
not
only
dependent
on
factors
like
genetics,
age,
environment,
and
exposure
to
infectious
agents
allergens
but
also
our
microbiota
diet.
It
has
been
known
for
centuries
that
food
can
influence
health
vulnerability
infection.
This
especially
true
infants,
young
children,
elderly.
review
focuses
how
nutrition
support
from
gestation
school-aged
children.
Immune
begins
during
pregnancy
by
mother’s
diet
transfer
nutritional
components
as
well
antibodies
her
fetus.
After
birth,
breastfeeding
crucial
importance
development
intestinal
an
infant.
If
possible,
early-life
formulas
are
alternative.
These
provide
several
functionalities
breastmilk,
key
nutrients
a
child
needs.
New
foods
introduced
after
weaning,
this
period,
children
switch
consuming
normal
However,
due
circumstances,
be
malnourished.
range
severe
protein/energy
malnutrition
micronutrient
deficiencies
obesity,
all
which
affect
system.
narrative
describes
challenges
in
early
life,
explores
life
nutrition,
provides
mechanistic
insight
into
relative
contribution
macronutrients,
micronutrients
other
immunomodulatory
life.
Medical Sciences,
Journal Year:
2025,
Volume and Issue:
13(2), P. 48 - 48
Published: April 29, 2025
Respiratory
virus
infections,
such
as
those
caused
by
influenza
viruses,
respiratory
syncytial
(RSV),
and
coronaviruses,
pose
a
significant
global
health
burden.
While
the
immune
system’s
adaptive
components,
including
memory
T
cells,
are
critical
for
recognizing
combating
these
pathogens,
recurrent
infections
variable
disease
outcomes
persist.
Memory
cells
key
element
of
long-term
immunity,
capable
responding
swiftly
upon
re-exposure
to
pathogens.
They
play
diverse
roles,
cross-reactivity
conserved
viral
epitopes
modulation
inflammatory
responses.
However,
protective
efficacy
is
influenced
several
factors,
evolution,
host
age,
system
dynamics.
This
review
explores
dichotomy
in
infections:
their
potential
confer
robust
protection
limitations
that
allow
breakthrough
infections.
Understanding
underlying
mechanisms
governing
formation,
maintenance,
functional
deployment
mucosa
improving
immunological
interventions.
We
highlight
recent
advances
vaccine
strategies
aimed
at
bolstering
cell-mediated
immunity
discuss
challenges
posed
evasion.
Addressing
gaps
knowledge
pivotal
designing
effective
therapeutics
vaccines
mitigate
burden
viruses.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(15), P. 2445 - 2445
Published: July 27, 2024
Viral
infections
pose
significant
global
challenges
due
to
their
rapid
transmissibility.
Therefore,
preventing
and
treating
these
promptly
is
crucial
curbing
spread.
This
review
focuses
on
the
vital
link
between
nutrition
viral
infections,
underscoring
how
dietary
factors
influence
immune
system
modulation.
Malnutrition,
characterized
by
deficiencies
in
essential
nutrients
such
as
vitamins
A,
C,
D,
E,
zinc,
can
impair
system,
thereby
increasing
vulnerability
potentially
leading
more
severe
health
outcomes
that
complicate
recovery.
Additionally,
emerging
evidence
highlights
role
of
commensal
microbiota
regulation,
which
affect
hosts’
susceptibility
infections.
Specific
components,
including
bioactive
compounds,
vitamins,
probiotics,
beneficially
modify
gut
microbiota,
thus
enhancing
response
offering
protection
against
aims
elucidate
mechanisms
adjustments
impact
pathogenesis
with
a
particular
focus
strengthening
system.
Immunological Reviews,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 16, 2024
Summary
The
prevalence
of
asthma,
rhinitis,
and
food
allergies
has
increased
dramatically
over
the
last
few
decades.
This
increase
originally
started
in
western
countries,
but
is
now
also
evident
many
other
regions
world.
Given
fact
that
so
quick,
noted
cannot
be
linked
to
a
genetic
effect,
environmental
factors
have
been
identified
are
associated
with
or
reduced
allergies,
like
changing
dietary
habits,
urbanization,
pollution,
exposure
microorganisms
LPS,
farming
environment
raw
milk
consumption.
Although
key
role
allergen‐specific
IgE
well
known,
IgG
IgA
antibodies
less
defined.
review
will
provide
an
overview
functions
allergy,
(IgG
(4)
IgA)
allergen
immunotherapy
(AIT),
possibility
use
for
treatment
ongoing
potential
tolerance
induction
allergens
preventive
setting.
In
last,
more
speculative,
section
we
present
novel
hypotheses
on
non‐IgE
by
directing
antigen
presentation,
Th2
development,
innate
immune
training.
British Journal of Hospital Medicine,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 11
Published: Jan. 9, 2025
Aims/Background
Lobar
pneumonia
is
an
acute
inflammation
with
increasing
incidence
globally.
Delayed
treatment
can
lead
to
severe
complications,
posing
life-threatening
risks.
Thus,
it
crucial
determine
effective
methods
improve
the
prognosis
of
children
lobar
pneumonia.
Therefore,
this
study
aimed
assess
clinical
efficacy
pidotimod-assisted
erythromycin
in
treating
over
3
years
old.
Methods
This
included
108
admitted
Huoqiu
First
People's
Hospital,
China,
between
March
2021
and
2024.
However,
6
(4
cases
missing
data,
1
autoimmune
disease,
asthma)
who
did
not
meet
predetermined
inclusion
criteria
were
excluded.
Based
on
methods,
divided
into
a
control
group
(n
=
52,
receiving
treatment)
observation
50,
treatment).
Furthermore,
efficacy,
signs,
resolution
time
symptoms,
cellular
immune
function,
adverse
reactions
retrospectively
evaluated.
Results
The
exhibited
significantly
lower
efficiency
than
(80.77%
vs
94.00%;
p
<
0.05).
showed
better
alleviating
fever,
cough,
tachypnea,
pulmonary
moist
rales
(p
0.001).
CD3+,
CD4+,
CD4+/CD8+
levels
comparable
both
groups
before
>
7
days
after
treatment,
increased
compared
Additionally,
there
was
no
significant
difference
Conclusion
Pidotimod-assisted
pneumonia,
improving
signs
symptoms
enhancing
function
without
risk
drug
reactions.
South of Russia ecology development,
Journal Year:
2025,
Volume and Issue:
19(4), P. 28 - 40
Published: Jan. 21, 2025
Aim.
To
analyze
existing
data
on
the
impact
of
mutations
in
human
genome
pathogenesis
respiratory
viral
infections
and
to
discuss
their
relevance
clinical
practice.
The
primary
objectives
include
describing
mechanisms
genetic
mutations,
reviewing
examples
genes
that
affect
susceptibility
disease
severity
evaluating
prospects
for
testing
personalized
medicine.Research
factors
influencing
demonstrates
significant
progression
outcomes.
For
instance,
IFITM3
gene,
which
plays
a
crucial
role
limiting
influenza
virus
replication,
along
with
its
rs12252‐C
polymorphism,
is
linked
severe
cases
influenza.
Similarly,
TLR7
gene
are
associated
manifestations
COVID‐19,
particularly
males.
These
findings
underscore
importance
identify
individuals
at
heightened
risk
emphasize
potential
medicine
enhance
patient
Additionally,
it
essential
consider
interplay
between
environmental
as
well
social
determinants
health.This
review
examines
influence
progression.
It
can
significantly
course
these
infections.
integrating
into
practice
efficiency
diagnosis,
prognosis
treatment
emphasized.
Pathogens,
Journal Year:
2025,
Volume and Issue:
14(3), P. 263 - 263
Published: March 7, 2025
Viral
infections
have
been
a
severe
challenge
for
global
public
health,
and
viral
pneumonia
is
becoming
increasingly
critical
in
the
post-pandemic
era.
Observational
basic
studies
demonstrated
strong
link
between
host
nutrient
status
anti-viral
immune
responses,
nutritional
supplements
were
shown
to
improve
prognosis
of
infectious
diseases.
However,
there
limited
research
on
relationship
essential
micronutrients
susceptibility
pneumonia.
In
addition,
current
are
often
confounded
by
biases
reverse
causality,
undermining
their
reliability.
this
study,
fill
gap,
we
employed
Mendelian
randomization
investigate
causal
supplementation
vitamins
minerals
Our
analysis
found
that
vitamin
B6
protective
factor
against
pneumonia,
while
selenium
risk
factor.
These
findings
provide
insights
use
dietary
prevention
control
especially
when
micronutrient
used
as
an
adjunctive
therapy
infections.
The Italian Journal of Pediatrics/Italian journal of pediatrics,
Journal Year:
2024,
Volume and Issue:
50(1)
Published: April 23, 2024
The
COVID-19
pandemic
have
impacts
on
the
prevalence
of
other
pathogens
and
people's
social
lifestyle.
This
study
aimed
to
compare
pathogen,
allergen
micronutrient
characteristics
pediatric
inpatients
with
pneumonia
prior
during
in
a
large
tertiary
hospital
Shanghai,
China.
Patients
admitted
Department
Pediatric
Pulmonology
Xinhua
Hospital
between
March-August
2019
2020
were
recruited.
And
clinical
patients
compared
those
2020.
Hospitalizations
for
decreased
by
74%
after
pandemic.
For
pathogens,
virus,
mycoplasma
pneumoniae
(MP)
mixed
infection
rates
all
much
lower
than
(P
<
0.01).
Regarding
allergens,
2019,
positive
house
dust
mite,
shrimp
crab
significantly
higher
micronutrients,
levels
vitamin
B2,
B6,
C
25-hydroxyvitamin
D
(25(OH)D)
observed
be
0.05).
participants,
longer
stay
(OR
=
1.521,
P
0.000),
milk
allergy
6.552,
0.033)
calcium
(Ca)
insufficiency
12.048,
0.019)
identified
as
high-risk
factors
severe
multivariate
analysis.
number
children
hospitalized
incidence
common
pathogen
infections
both
reduced,
that
status
also
changed
outbreak
