Association between levels of blood trace minerals and periodontitis among United States adults

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: Sept. 7, 2022

Evidence linking trace minerals and periodontitis is limited. To investigate the relationship between (selenium, manganese, lead, cadmium, mercury) periodontitis, data from National Health Nutrition Examination Survey (NHANES) were analyzed after accounting for potential confounding factors. No known studies have explored these five periodontitis.A total of 4,964 participants who had undergone a full-mouth periodontal examination laboratory tests studied in cross-sectional study. Clinical attachment loss (CAL) grading used to measure severity. Linear logistic regression models evaluate association periodontitis. Further subgroup analyses performed.Blood lead cadmium levels positively associated with mean CAL, blood selenium was negatively CAL; however, mercury, CAL not significantly associated. The more significant males, elderly, patients diabetes. There threshold effect CAL. Among Black population, followed an inverted U-shaped curve. saturation study people aged 45-59 years old.Our highlighted that selenium, nationally representative sample United States adults.

Language: Английский

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The Role of Diet and Specific Nutrients during the COVID-19 Pandemic: What Have We Learned over the Last Three Years?

International Journal of Environmental Research and Public Health, Journal Year: 2023, Volume and Issue: 20(7), P. 5400 - 5400

Published: April 4, 2023

Nutrients and diets have an important impact on our immune system infection risk a huge number of papers been published dealing with various aspects nutrition in relation to SARS-CoV-2 or COVID-19 severity. This narrative review aims give update this association tries summarize some the most findings after three years pandemic. The analysis major studies systematic reviews leads conclusion that healthy plant-based diet reduces risks for especially Regarding micronutrients, vitamin D is fore, but also zinc, C and, extent, selenium may play role COVID-19. Furthermore, omega-3-fatty acids their anti-inflammatory effects deserve attention. Therefore, aim societal nutritional efforts future should be foster high quality diet, which not only exerts beneficial non-communicable diseases such as type 2 diabetes obesity are primary factors worse outcomes. Another focus good supply critical immune-effective nutrients, zinc.

Language: Английский

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Immune proteins recovered in tooth enamel as a biochemical record of health in past populations: Paleoproteomic analysis of Mission Period Native Californians

Journal of Archaeological Science, Journal Year: 2024, Volume and Issue: unknown, P. 106069 - 106069

Published: Sept. 1, 2024

Language: Английский

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Unveiling the potential pleiotropic effects of metformin in treating COVID-19: a comprehensive review

Frontiers in Molecular Biosciences, Journal Year: 2023, Volume and Issue: 10

Published: Oct. 10, 2023

This review article explores the potential of metformin, a medication commonly used for type 2 diabetes, as an antiviral and anti-inflammatory agent in context coronavirus disease 2019 (COVID-19). Metformin has demonstrated inhibitory effects on growth SARS-CoV-2 cell culture models shown promising results reducing viral load achieving undetectable levels clinical trials. Additionally, metformin exhibits properties by production pro-inflammatory cytokines modulating immune function, which may help prevent cytokine storms associated with severe COVID-19. The drug’s ability to regulate balance between Th17 cells Treg suggests its mitigating inflammation restoring T functionality. Furthermore, metformin’s modulation gut microbiota, particularly changes bacterial taxa short-chain fatty acids, contribute therapeutic effects. interplay bile microbiome, glucagon-like peptide-1 secretion, glycemic control implications management diabetes interventions By refreshing current evidence, this highlights option COVID-19, while also exploring microbiome immunometabolism.

Language: Английский

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Resurgence of influenza during COVID‐19 in Chongqing, China: A retrospective analysis

Journal of Medical Virology, Journal Year: 2023, Volume and Issue: 95(11)

Published: Nov. 1, 2023

To better understand the trends of influenza and impact public health social measures (PHSMs) implemented during coronavirus disease 2019 (COVID-19) period in Chongqing, China. Data from China Influenza Surveillance Information System January 2017 to June 2022 were extracted. Epidemiological characteristics (influenza-like illness [ILI] ILI%) virological (influenza positive rate circulating (sub)types) described compared between pre-COVID-19 COVID-19 period. Our survey showed that implementation PHSMs had a on reducing transmission. However, activity resurged 2021-2022 as eased. Children under 5 years old constituted highest proportion ILI cases. The overall was 23.70%, with higher observed (31.55%) (13.68%). virus subtypes co-circulated predominant subtype varied each year, A predominated 2018/2019, while B/Victoria lineage dominated 2020/2021. are effective mitigate spread influenza. findings underscore need for bolstering monitoring systems, advocating vaccination, implementing practical strengthen prevention control against

Language: Английский

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Effects of Dietary Supplementation with Carrot-Derived Rhamnogalacturonan-I (cRG-I) on Accelerated Protective Immune Responses and Quality of Life in Healthy Volunteers Challenged with Rhinovirus in a Randomized Trial

Nutrients, Journal Year: 2022, Volume and Issue: 14(20), P. 4258 - 4258

Published: Oct. 12, 2022

An adequate and balanced supply of nutrients is essential for maintaining health, an optimal immune response fast, contained properly controlled, curbing infections quickly while minimizing damage. Several micronutrients contribute to normal function certain dietary fibers, example pectic polysaccharides, can play important role in educating regulating cell responses. The aim this paper elaborate on our initial findings that supplementation with carrot-derived rhamnogalacturonan-I (cRG-I) accelerates augments local innate anti-viral interferon a rhinovirus-16 (RV16) infection reduces the severity duration symptoms humans. Dietary intake cRG-I also enhanced responses respiratory viral as measured by ex vivo stimulation whole blood Toll-like receptor 3 (TLR3) ligand polyinosinic:polycytidylic acid NK function. Consumption reduced negative effects common cold quality life assessed individual symptom scores. RG-I from carrot safe, sustainable, economically viable solution could easily be integrated into food products supplements aiming support fitness wellbeing.

Language: Английский

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Genetic Diversity and Evolutionary Kinetics of Influenza A Virus H3N2 Subtypes Circulating in Riyadh, Saudi Arabia

Vaccines, Journal Year: 2023, Volume and Issue: 11(3), P. 702 - 702

Published: March 20, 2023

Presence of a large foreign workforce and the annual gathering people for pilgrimage from around globe have significantly contributed to emergence diversity respiratory viruses in Saudi Arabia. Here, we report sequence phylogenetic analysis H3N2 subtype influenza A virus (IAV) clinical samples collected Riyadh, Based on RT-PCR, IAV was found 88 (28.3%) 311 screened. Of 88-IAV positive samples, 43 (48.8%) were H1N1 while remaining 45 (51.2%) be subtype. Complete sequencing HA NA genes revealed, twelve nine amino acid (AA) substitutions respectively, importantly, these variations are absent current vaccine strains. analysis, majority strains grouped same clades as Importantly, N-glycosylation sites at AA 135(NSS) unique 6 investigated HA1 protein These data may significant implications designing novel population-based vaccines underscore need regular monitoring efficacy due emerging variants.

Language: Английский

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Multitarget Mechanism of Artemisia Plants to Fight Respiratory Tract Infections Based on Network Pharmacology and Molecular Docking

Natural Product Communications, Journal Year: 2024, Volume and Issue: 19(4)

Published: April 1, 2024

Objective: To study the mechanism of Artemisia in treatment respiratory tract infection (RTI) by network pharmacology and molecular docking. Methods: The active constituents targets were screened Traditional Chinese Medicine Systems Pharmacology Database Analysis Platform (TCMSP). Gene Cards database to obtain disease associated with RTI. key intersection used construct protein–protein interaction (PPI) network, hub gene was obtained through topological analysis regulation traditional medicine. analyzed R language enrichment, regulatory diagram target function/pathway constructed. Molecular docking verifies binding drug predicted pharmacology. Results: 144 components regulated 133 proteins related RTI, core β-sitosterol, quercetin, isorhamnetin, artemisinin, etc. ontology enrichment showed that regulates receptor ligand activity, cytokine other functions acting on membrane region, raft cellular structures thus affecting biological processes such as response drugs bacteria-derived molecules. Kyoto Encyclopedia Genes Genomes indicated phosphatidylinositol 3-kinase (PI3K)-protein kinase B (Akt), tumor necrosis factor, interleukin-17 (IL-17) signaling pathway main for RTI treatment. method confirmed high affinity between ingredient target. Conclusions: species, a multitarget medication, has been shown be viable therapy option techniques based data mining approaches.

Language: Английский

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Proton pump inhibitors and risk of severe COVID-19 in older people

Age and Ageing, Journal Year: 2024, Volume and Issue: 53(4)

Published: April 1, 2024

Abstract Introduction Severe acute respiratory syndrome coronavirus 2 is a viral infection that can cause systemic disorders and lead to death, particularly in older people. Proton pump inhibitors (PPIs) increase the risk of enteric lung infections. Considering broad use PPIs people, potential role COVID-19 could be dramatic significance. The objective our study was evaluate link between severe Method We performed retrospective cohort study, including all patients aged ≥65, hospitalised for diagnosis COVID-19. Epidemiological, clinical biological data were extracted we an Inverse Probability Treatment Weighing method based on propensity score. Results From March 2020 February 2021, total 834 included, with median age 83 52.8% male. A 410 had prescription, 358 (87.3%) long-term PPIs-users 52 (12.7%) recent PPIs-users. Among PPIs-users, 163 (39.8%) developed versus 113 (26.7%) PPIs-non users (odds ratio (OR) = 1.59 [1.18–2.14]; P < 0.05). Moreover, double dose PPI-users higher developing (OR 3.36 [1.17–9.66]; 0.05) than full 2.15 [1.22–3.76]; half 1.64 [1.13–2.37]; Conclusion Our reports evidence associated increased

Language: Английский

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MFGM-enriched whey displays antiviral activity against common pediatric viruses in vitro

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: July 31, 2024

Among the most common mucosal viral infections in infants are rotavirus, one of main causes severe gastroenteritis and children up to 5 years, respiratory syncytial virus (RSV), leading lower tract infections. Both human milk bovine derived factors may provide protection against More recently, a similar activity proteins was suggested for SARS-CoV-2. The goal current study test antiviral milkfat globule membrane (MFGM) RSV SARS-CoV-2 further characterize MFGM-enriched whey identify which components contribute inhibitory activity.

Language: Английский

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