MFGM-enriched whey displays antiviral activity against common pediatric viruses in vitro

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: July 31, 2024

Among the most common mucosal viral infections in infants are rotavirus, one of main causes severe gastroenteritis and children up to 5 years, respiratory syncytial virus (RSV), leading lower tract infections. Both human milk bovine derived factors may provide protection against More recently, a similar activity proteins was suggested for SARS-CoV-2. The goal current study test antiviral milkfat globule membrane (MFGM) RSV SARS-CoV-2 further characterize MFGM-enriched whey identify which components contribute inhibitory activity.

Language: Английский

---

Innovative use of Biomagic-Enzyme complex for pig farm odor reduction, harmful bacteria inhibition, and immune enhancement

Korean Journal of Veterinary Research, Journal Year: 2024, Volume and Issue: 64(4), P. e32 - e32

Published: Dec. 30, 2024

The global increase in livestock production has correspondingly intensified farm odors due to harmful bacteria, reduced immunity, and disease progression. In this study, we treated feces with Biomagic-Enzyme complex for 4 months understand the relationship between odor, immunity against common viral diseases, immune cytokines, changes microbiota. A gas meter (MultiRAE) was used measure ammonia (NH3) hydrogen sulfide (H2S) while odor intensity offensiveness were characterized by non-objective scaling method. complete blood count performed plasma obtained after centrifugation at 3,000 rpm 20 minutes. cytokine profile evaluated using commercial kits. Microbial DNA extracted purified from fecal samples analyze RNA/DNA amplified determine expression of transmissible gastroenteritis virus (TGEV), porcine reproductive respiratory syndrome (PRRS), circovirus type 2 (PCV2). Our results indicated that Biomagic nuisance decreasing levels, resulting faint fairly offensive intensity. After enzyme treatment, Escherichia coli populations significantly across all 3 farms. contrast, beneficial Lactobacillus spp. levels remained stable, indicating selectively targeted bacteria preserving ones. Lachnospiraceae, Spirochaetaceae, Bacteroidaceae found be higher third month treatment. TGEV not detected, PRRS non-pathogenic PCV2 showed a positive infection rate. conclusion, ammonia, prevented pig farms, improved gut-beneficial

Language: Английский

---

Evaluation of nutritional status in lung transplant recipients and its correlation with post-transplant short-term prognosis: a retrospective study

Annals of Translational Medicine, Journal Year: 2022, Volume and Issue: 10(14), P. 793 - 793

Published: July 1, 2022

Lung transplantation is an effective treatment for saving the lives of patients with end-stage lung disease (ESLD). transplant-related morbidity and mortality has significantly higher than other solid organ transplants. Among pre-transplant variables that affect survival rate after transplantation, nutritional status are associated poor rate. In order to provide basis formulating evaluations transplant recipients in future, we retrospectively analyzed explore its correlation short-term prognosis.This retrospective cohort study included who were hospitalized 2020 underwent surgery at Shanghai Pulmonary Hospital. Inclusion criteria: (I) aged ≥18 years; (II) have been diagnosed ESLD; (III) received no treatments; (IV) undergone a We summarized patients' general information, including their sex, age, major etc. And also collected status, such as Nutritional Risk Screening 2002 (NRS 2002), subjective global assessment (SGA) nutritional-related indicators, albumin, prealbumin, retinol-binding protein before 1 month surgery. addition, postoperative drainage volume, length stay intensive care unit (ICU), total hospital days, hospitalization costs evaluate prognosis.A 33 successfully Of patients, 16 had preoperative NRS scores ≥3 points, whom 7 assessed by SGA having mild-moderate malnutrition 9 severe malnutrition. The albumin indexes these calcium contents, lower those <3. Patients volumes, longer times, <3.Lung incidence risk malnutrition, which seriously affects prognosis. Thus, clinical practice, should be screened provided support maintain good improve

Language: Английский

---

Direct Binding of Bovine IgG-Containing Immune Complexes to Human Monocytes and Their Putative Role in Innate Immune Training

Nutrients, Journal Year: 2022, Volume and Issue: 14(21), P. 4452 - 4452

Published: Oct. 22, 2022

Bovine milk IgG (bIgG) was shown to bind and neutralize the human respiratory synovial virus (RSV). In animal models, adding bIgG prevented experimental RSV infection increased number of activated T cells. This enhanced activation RSV-specific cells may be explained by receptor-mediated uptake antigen presentation after binding bIgG-RSV immune complexes (ICs) with FcγRs (primarily CD32) on indirect effect ICs confirmed previously in cell cultures. However, direct antigen-presenting has not been addressed. As bovine can induce innate training, we hypothesized that this could caused more efficiently ICs. Therefore, characterized expression CD16, CD32, CD64 (peripheral blood mononuclear (PBMCs), determined optimal conditions form preF protein, demonstrated these CD14+ monocytes. Similarly, complexed a murine anti-bIgG mAb also bound To evaluate whether training than itself, resulted ICs, as well bIgG, were used an vitro model. Training containing protein-but alone-induced significantly higher TNF-α production upon LPS R848 stimulation. protein itself nonsignificantly cytokine well. its tropism insulin-like growth factor receptor 1 (IGFR1), IGF reported training. Even so, data suggest role for IgG-containing inducing re-exposure pathogens. mouse did effect, further research is needed confirm putative enhancing responses vivo.

Language: Английский

---

Changing clinical characteristics of pediatric inpatients with pneumonia during COVID-19 pandamic: a retrospective study

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 10, 2024

Abstract Background: The COVID-19 pandemic have impacts on the prevalence of other pathogens and people’s social lifestyle. This study aimed to compare pathogen, allergen micronutrient characteristics pediatric inpatients with pneumonia prior during in a large tertiary hospital Shanghai, China. Methods: Patients admitted Department Pediatric Pulmonology Xinhua Hospital between March-August 2019 2020 were recruited. And clinical patients compared those 2020. Results: Hospitalizations for decreased by 74% after pandemic. For pathogens, virus, mycoplasma pneumoniae (MP) mixed infection rates all much lower than ( P < 0.01). Regarding allergens, 2019, positive house dust mite, shrimp crab significantly higher micronutrients, levels vitamin B2, B6, C 25-hydroxyvitamin D (25(OH)D) observed be 0.05). participants, longer stay (OR = 1.521, 0.000), milk allergy 6.552, 0.033) calcium (Ca) insufficiency 12.048, 0.019) identified as high-risk factors severe multivariate analysis. Conclusions: number children hospitalized incidence common pathogen infections both reduced, that status also changed outbreak

Language: Английский

---