Recent progress and the emerging role of lncRNAs in cancer drug resistance; focusing on signaling pathways

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 253, P. 154999 - 154999

Published: Nov. 29, 2023

Language: Английский

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PD-1/PD-L1 Inhibitors Response in Triple-Negative Breast Cancer: Can Long Noncoding RNAs Be Associated?

Cancers, Journal Year: 2023, Volume and Issue: 15(19), P. 4682 - 4682

Published: Sept. 22, 2023

As immune checkpoint inhibitors (ICI) emerge as a paradigm-shifting treatment option for patients with advanced or metastatic cancer, there is growing demand biomarkers that can distinguish which are likely to benefit. In the case of triple-negative breast cancer (TNBC), characterized by lack therapeutic targets, pembrolizumab approval high-risk early-stage disease occurred regardless PD-L1 status, keeps condition in biomarker limbus. this review, we highlight participation long non-coding RNAs (lncRNAs) regulation PD-1/PD-L1 pathway, well definition prognostic immune-related signatures many types tumors, aiming shed light on molecules deserve further investigation potential role biomarkers. We also conducted bioinformatic analysis investigate lncRNAs already investigated PD-1/PDL-1 pathways other types, considering TNBC molecular context. sense, from generated data, evidence here two lncRNAs, UCA1 and HCP5, have not yet been identified context tumoral response cancer. These candidates be explored verify their use ICI response. article, present an updated review regarding lncRNA ICI, highlighting versatility using these molecules.

Language: Английский

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Targeting CERS6-AS1/FGFR1 axis as synthetic vulnerability to constrain stromal cells supported proliferation in Mantle cell lymphoma

Leukemia, Journal Year: 2024, Volume and Issue: 38(10), P. 2196 - 2209

Published: July 13, 2024

Language: Английский

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Unveiling the nexus: Long non-coding RNAs and the PI3K/Akt pathway in oral squamous cell carcinoma

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 262, P. 155540 - 155540

Published: Aug. 12, 2024

Language: Английский

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Chemotherapy-mediated lncRNA-induced immune cell plasticity in cancer immunopathogenesis

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 141, P. 112967 - 112967

Published: Aug. 24, 2024

Language: Английский

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