Tumor Microenvironment Dynamics of Triple-Negative Breast Cancer Under Radiation Therapy

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2795 - 2795

Published: March 20, 2025

Triple-negative breast cancer (TNBC) is an aggressive subtype of characterized by the absence estrogen receptors (ER), progesterone (PR), and HER2 expression. While TNBC relatively less common, accounting for only 10–15% initial diagnosis, due to its nature, it carries a worse prognosis in comparison hormone receptor-positive counterparts. Despite significant advancements screening, treatment cancer, remains important public health burden. Following with chemotherapy, surgery, radiation, over 40% patients experience relapse within 3 years achieve least benefit from post-mastectomy radiation. The tumor microenvironment environment (TME) pivotal initiation, progression, immune evasion, resistance, prognosis. TME complex network that consists cells, non-immune soluble factors located region adjacent modulates therapeutic response differentially between TNBC. mechanisms underlying radiation resistance remain unclear, immunosuppressive has been implicated chemotherapeutic resistance. Radiation therapy (RT) known alter TME; however, changes elicited are poorly date, whether these contribute unknown. This review delves into distinct characteristics TME, explores how RT influences dynamics, examines radiosensitization, radioresistance, responses.

Language: Английский

---

Harnessing Drug Repurposing to Combat Breast Cancer by Targeting Altered Metabolism and Epithelial-to-Mesenchymal Transition Pathways

ACS Pharmacology & Translational Science, Journal Year: 2024, Volume and Issue: 7(12), P. 3780 - 3794

Published: Oct. 31, 2024

Breast cancer remains one of the most prevalent and challenging cancers to treat due its complexity heterogenicity. Cellular processes such as metabolic reprogramming epithelial-to-mesenchymal transition (EMT) contribute breast by driving uncontrolled cell division, metastasis, resistance therapies. Strategically targeting these intricate pathways can effectively impede progression, thereby revealing significant potential for therapeutic interventions. Among various emerging approaches, drug repurposing offers a promising avenue enhancing clinical outcomes. In recent years, high-throughput screening, QSAR, network pharmacology have been widely employed identify repurposed drugs. As an outcome, several drugs, Metformin, Itraconazole, Pimozide, Disulfiram, were regulate EMT pathways. Moreover, strategies combination therapy, targeted delivery, personalized medicine utilized enhance efficacy specificity This review focuses on altered metabolism in through repurposing. It also highlights advancements screening techniques, associated limitations, overcome challenges.

Language: Английский

---

Reshaping the Landscape of Locoregional Treatments for Breast Cancer Liver Metastases: A novel, intratumoral, p21-targeted percutaneous therapy increases survival in BALB/c mice inoculated with 4T1 triple negative breast cancer cells in the liver

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

Patients with disseminated metastatic disease from breast cancer are likely to have liver involvement in >50% of cases at some point during progression. These patients a poor prognosis; and, when treated the standard care systemic therapy they median survival <9-months. Increasing will require administration better therapies that specifically targeted treat distant metastases. One approach increasing treatment efficacy for metastases is through application locoregional therapies. Locoregional an appealing interventional since these tumor lesions accessible via minimally invasive procedures can be administered using either ultrasound or CT imaging. Current non-specific and not produced significant increases survival. The goal this study was design test therapeutic intervention lead candidate, fixed-dose small-molecule drug called MBC-005, tested

Language: Английский

---

The role of ceRNAs in breast cancer microenvironmental regulation and therapeutic implications

Journal of Molecular Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 6, 2024

Language: Английский

---