Classification and epidemiology of vasculitis: Emerging concepts DOI Creative Commons

Tegwen Ecclestone,

Richard A. Watts

Best Practice & Research Clinical Rheumatology, Journal Year: 2023, Volume and Issue: 37(1), P. 101845 - 101845

Published: March 1, 2023

The recent publication of the American College Rheumatology (ACR)-European Alliance Associations for (EULAR) classification criteria large vessel vasculitis and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAVs) has provided modern these conditions, which incorporate contemporary methods investigation diagnosis. Further validation is required in independent cohorts, especially from populations that were not well represented development cohort. Studies occurrence report Takayasu arteritis a rare disease most populations, giant cell common older populations. incidence AAV appears to have plateaued, but prevalence increasing as result lower mortality. new may affect reported prevalence, studies will be needed confirm this. impact COVID-19 on completely known, there evidence reduced Kawasaki IgA-associated following lockdowns with transmission possible trigger infectious agents.

Language: Английский

Common Seasonal Pathogens and Epidemiology of Henoch-Schönlein Purpura Among Children DOI Creative Commons
Arthur M. Felix, Zein Assad, Philippe Bidet

et al.

JAMA Network Open, Journal Year: 2024, Volume and Issue: 7(4), P. e245362 - e245362

Published: April 5, 2024

Importance Henoch-Schönlein purpura (HSP) is the most common type of vasculitis in children. The factors that trigger disease are poorly understood. Although several viruses and seasonal bacterial infections have been associated with HSP, differentiating specific associations these pathogens onset HSP remains a challenge due to their overlapping patterns. Objective To analyze role epidemiology HSP. Design, Setting, Participants This cohort study comprised an interrupted time-series analysis patient records from comprehensive national hospital-based surveillance system. Children younger than 18 years hospitalized for France between January 1, 2015, March 31, 2023, were included. Exposure Implementation relaxation nonpharmaceutical interventions (NPIs) COVID-19 pandemic, such as social distancing mask wearing. Main Outcomes Measures main outcomes monthly incidence per 100 000 children, analyzed via quasi-Poisson regression model, estimated percentage potentially 14 selected over same period. Results included 9790 children (median age, 5 [IQR, 4-8 years]; 5538 boys [56.4%]) 757 110 infectious diseases 0.7 0.2-2 393 697 [52.0%]). decreased significantly after implementation NPIs 2020 (−53.6%; 95% CI, −66.6% −40.6%; P < .001) increased April 2021 (37.2%; 28.0%-46.3%; .001). Streptococcus pneumoniae was 37.3% (95% 22.3%-52.3%; .001), cases pyogenes 25.6% 16.7%-34.4%; human rhino enterovirus 17.1% 3.8%-30.4%; = .01). Three sensitivity analyses found similar results. Conclusions Relevance significant changes simultaneously major shifts circulating pandemic indicated approximately 60% pneumococcus group A streptococcus. finding suggests preventive measures against could reduce pediatric

Language: Английский

Citations

9
Causal relationships between circulating inflammatory factors and IgA vasculitis: a bidirectional Mendelian randomization study DOI Creative Commons
Jiading Qin, Ling Zhang, Bo Ke

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 11, 2023

Background IgA vasculitis (IgAV) is an immune-associated vasculitis, yet its exact etiology remains unclear. Here, we explore the interaction between IgAV and inflammatory factors using bidirectional Mendelian randomization (MR). Methods We conducted a summary-level MR analysis to delineate causality of C-reactive protein (CRP), procalcitonin (PCT), 41 circulating regulators with IgAV. Data on genetic variants related inflammation were obtained from three genome-wide association studies (GWASs) CRP, PCT, human cytokines, whereas data was large meta-analyses GWAS among 216 569 FinnGen Biobank participants. The primary performed inverse-variance weighted (IVW) approach, sensitivity analyses carried out MR-Egger, median, mode, MR-pleiotropy residual sum outlier. Results This study revealed CRP higher levels increased risk through IVW method (Estimate odds ratio [OR] = 1.41, 95% confidence interval [CI]: 1.01-1.98, P 0.04), MR-Egger (OR 1.87, CI: 1.15-3.02, 0.01), median 2.00, 1.21-3.30, 0.01) mode 1.74, 1.13-2.68, 0.02). Furthermore, elevated IL-8 strongly implicated (IVW OR 1.42, 1.05-1.92; Conversely, genetically predicted associated decreased TNF-β estimate β -0.093, -0.178 - -0.007; 0.033). Additionally, no such significant statistical differences for other found. Conclusion Our current provides compelling evidence causal effect These findings contribute better understanding pathogenesis emphasize potential targeting therapeutic interventions.

Language: Английский

Citations

16
New insights into epidemiological data and impact of the COVID-19 pandemic on IgA vasculitis in children and adults: a French nationwide cohort DOI
Valentin Maisons, Yanis Ramdani, Antoine Hankard

et al.

Rheumatology International, Journal Year: 2023, Volume and Issue: 43(10), P. 1791 - 1798

Published: July 12, 2023

Language: Английский

Citations

11
The extent of intestinal involvement is closely related to the severity of IgAV: a risk stratification study based on CT DOI Creative Commons
Yuanqiu Li, Ziman Xiong, Yufan Wang

et al.

Annals of Medicine, Journal Year: 2025, Volume and Issue: 57(1)

Published: Feb. 7, 2025

To analyze the differences in clinical manifestations between children and adults with intestinal involvement IgAV to identify specific subtypes requiring particular attention. A systematic review of HIS system was conducted on patient data from four centers at Tongji Hospital January 2015 October 2022. Patients a diagnosis were further analyzed. Clinical manifestations, laboratory data, CT findings time initial hospitalization recorded. The extent involvement, linked disease severity, quantitatively assessed by evaluating number affected segments imaging. Laboratory markers that could reflect severe explored. Furthermore, patients classified based sites involved segments: L1 type (duodenum and/or jejunum), L2 (ileum), L3 jejunum ileum), L4 (limited colorectum). comparison first three types performed. total 148 enrolled (67 81 adults). proportion joint pain renal higher adults. D-dimer level an independent risk factor for (OR = 1.104, p .016). In segments, it found had longer hospital stay. With exception there no significant symptoms imaging provided objective insights into which correlated severity. widespread small bowel displayed more state.

Language: Английский

Citations

0
National recommendations for the management of children and young people with IgA vasculitis: a best available evidence, group agreement-based approach DOI Creative Commons
Louise Oni, Caroline Platt, Matko Marlais

et al.

Archives of Disease in Childhood, Journal Year: 2024, Volume and Issue: unknown, P. archdischild - 327364

Published: Oct. 8, 2024

Objective IgA vasculitis (IgAV) is the most frequently experienced subtype of seen in children. Most children fully recover, however, complications including chronic kidney disease are recognised. The aim this project was to use a best available evidence, group agreement, based approach develop national recommendations for initial management IgAV and its associated complications. Methods A representative multiprofessional guideline development (GDG), consisting 28 members, formed met monthly. Graded were generated using nationally accredited methods, which included predefined scope, open consultation, systematic literature review, evidence appraisal, review or international guidelines period consultation. Audit measures research priorities incorporated. Results GDG over 14-month period. total 82 papers relevant synthesis. For management, four topic areas identified with five key questions generating six graded related classification, specialist referral musculoskeletal involvement. complications, 12 15 covering nephritis, gastrointestinal testicular involvement, atypical follow-up. Open consultation feedback endorsed by UK Kidney Association Royal College Paediatrics Child Health online. Conclusion Despite being rare limited standardised clinical young people has been achieved. This should unite approaches care act as foundation improvement.

Language: Английский

Citations

3
The influence of respiratory infections on Henoch-Schönlein purpura in children DOI Creative Commons
Bili Wang,

Wenqing Xiang,

Zhouyue Zhu

et al.

BMC Infectious Diseases, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 24, 2025

To explore the influence of respiratory infections on onset Henoch-Schönlein Purpura (HSP) in children, along with exploring potential underlying mechanisms. The present study conducted a statistical analysis renal involvement indicators 296 children HSP who came to Children's Hospital Zhejiang University, as well IgA levels 400 and HSP. Compared control group, exhibited significant increase urine red blood cell count, microalbuminuria, protein/creatinine ratio (P < 0.001). monthly outpatient visits for similar pattern those HSP, demonstrating heightened prevalence during autumn winter. level were significantly higher than group can give rise complications such involvement. There exists certain correlation between occurrence which may be attributed elevation induced by infections. In conclusion, should reinforce protective measures peak influenza season order prevent

Language: Английский

Citations

0
Single-cell transcriptomics reveals the alteration of immune cell profile in peripheral blood of Henoch-Schonlein purpura DOI Creative Commons
Wenhui Zhou, Meiling Zheng,

Zhi Hu

et al.

Clinical Immunology, Journal Year: 2025, Volume and Issue: unknown, P. 110443 - 110443

Published: Feb. 1, 2025

Language: Английский

Citations

0
Antibiotic‐induced IgA vasculitis: insights from a real‐world retrospective analysis and pharmacovigilance assessment DOI
Hong Zheng, Leping Liu, Minghua Yang

et al.

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: Feb. 11, 2025

Language: Английский

Citations

0
An Atypical Presentation of Henoch-Schönlein Purpura With Features of Acute Hemorrhagic Edema of Infancy and Koebnerization: A Case Report DOI Open Access

Amira Basyouny,

Ahmad Imam,

Kamal A Abouzaid

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Immunoglobulin A vasculitis, also known as Henoch-Schönlein purpura (HSP), is a type of vasculitis that most commonly found in children. Palpable key feature and often associated with joint, abdominal, or renal involvement. This case report presents an atypical presentation HSP four-year-old male, characterized by overlapping features Acute Hemorrhagic Edema Infancy (AHEI) Koebnerization (isomorphic response), which complicates the diagnosis. The patient initially presented redness around his mouth nose, followed hematuria development palpable on lower extremities buttocks. Vascular swellings were noted palms, feet, face, cockade appeared upper extremities. exhibited episodic joint pain, genital edema, back diagnosis this was challenged presence AHEI-like Koebnerization. responded well to treatment prednisone colchicine. underscores clinical overlap between AHEI, rare occurrence HSP. It emphasizes importance recognizing presentations ensure timely accurate Further research required explore frequency, pathophysiology, implications such cases enhance diagnostic accuracy management pediatric vasculitis.

Language: Английский

Citations

0
Adenovirus: a possible trigger for IgA vasculitis in children DOI
Anand Mannu,

Biju Vasudevan,

Ahmed Waheed Kashif

et al.

BMJ Case Reports, Journal Year: 2025, Volume and Issue: 18(2), P. e262856 - e262856

Published: Feb. 1, 2025

IgA vasculitis (IgAV), also called Henoch–Schönlein purpura (HSP), is an immune complex characterised by IgA1‐dominant deposits affecting small vessels (predominantly capillaries, venules or arterioles). It often involves the skin and gastrointestinal tract, frequently causes arthritis rarely in kidney indistinguishable from nephropathy. usually presents as a purpuric non-blanching rash mostly on lower limbs, although it may extend to upper limbs trunk, more face. Respiratory tract infection history of exposure antigens certain foods, insects, drugs vaccines trigger pathogenesis IgAV. Adenovirus acute respiratory diseases occasionally gastroenteritis. Literature adenovirus direct involvement onset IgAV scarce. We report few cases where associated with infection, research required establish this association.

Language: Английский

Citations

0