Clinical Nutrition, Journal Year: 2024, Volume and Issue: 43(6), P. 1459 - 1472
Published: April 12, 2024
Language: Английский
Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)
Published: March 7, 2023
Abstract Cuproptosis was a copper-dependent and unique kind of cell death that separate from existing other forms death. The last decade has witnessed considerable increase in investigations programmed death, whether copper induced an independent form long been argued until mechanism cuproptosis revealed. After that, increasing number researchers attempted to identify the relationship between process cancer. Thus, this review, we systematically detailed systemic cellular metabolic processes copper-related tumor signaling pathways. Moreover, not only focus on discovery its mechanism, but also outline association cancers. Finally, further highlight possible therapeutic direction employing ion ionophores with cuproptosis-inducing functions combination small molecule drugs for targeted therapy treat specific
Language: Английский
Citations
409
Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13
Published: March 23, 2023
Copper is an essential micronutrient for human body and plays a vital role in various biological processes including cellular respiration free radical detoxification. Generally, copper metabolism the stable state, there are specific mechanisms to regulate maintain homeostasis. Dysregulation of may have great connection with types diseases, such as Wilson disease causing overload Menkes deficiency. Cancer presents high mortality rates world due unlimited proliferation potential, apoptosis escape immune properties induce organ failure. thought cancer, elevated levels cancer tissue serum. also affects tumor progression by affecting angiogenesis, metastasis other processes. Notably, cuproptosis novel form cell death that provide targeting strategies developing therapy. chelators ionophores two coordinating compounds treatment cancer. This review will explore relationship between cancers, clarify targeted
Language: Английский
Citations
71
Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14
Published: Sept. 12, 2023
Copper is an indispensable micronutrient for the development and replication of all eukaryotes, its redox properties are both harmful beneficial to cells. An imbalance in copper homeostasis thought be involved carcinogenesis. Importantly, cancer cell proliferation, angiogenesis, metastasis cannot separated from effects copper. Cuproposis a copper-dependent form death that differs other existing modalities regulatory death. The role cuproptosis pathogenesis nervous cardiovascular systems has been widely studied; however, impact on malignant tumors yet fully understood clinical perspective. Exploring signaling pathways related will undoubtedly provide new perspective anti-tumor drugs future. Here, we systematically review systemic cellular metabolic processes mechanisms cancer. In addition, discuss possibility targeting ion prolong survival patients, with emphasis most representative ionophores chelators. We suggest attention should paid potential value treatment specific cancers.
Language: Английский
Citations
23
Heliyon, Journal Year: 2024, Volume and Issue: 10(5), P. e27496 - e27496
Published: March 1, 2024
Copper, a vital trace element, orchestrates diverse cellular processes ranging from energy production to antioxidant defense and angiogenesis. Copper metabolism cuproptosis are closely linked in the context of human diseases, with particular focus on cancer. Cuproptosis refers specific type copper-mediated cell death or copper toxicity triggered by disruptions within cells. This phenomenon encompasses spectrum mechanisms, such as oxidative stress, mitochondrial dysfunction, endoplasmic reticulum perturbations metal ion equilibrium. Mechanistically, is driven binding lipoylated enzymes tricarboxylic acid (TCA) cycle. interaction participates protein aggregation proteotoxic ultimately culminating death. Targeting its associated pathways cancer cells holds therapeutic potential selectively targeting eliminating cancerous Strategies modulate levels, enhance excretion, interfere cuproptotic being explored identify novel targets for therapy improve patient outcomes. Understanding relationship between malignancies remains an active area research. review provides comprehensive overview association metabolism, homeostasis, cancers, explicitly emphasizing mechanism implications pathogenesis. Additionally, we emphasize aspects treatment.
Language: Английский
Citations
16
Cellular & Molecular Biology Letters, Journal Year: 2024, Volume and Issue: 29(1)
Published: June 25, 2024
Abstract Cuproptosis, a newly identified copper (Cu)-dependent form of cell death, stands out due to its distinct mechanism that sets it apart from other known death pathways. The molecular underpinnings cuproptosis involve the binding Cu lipoylated enzymes in tricarboxylic acid cycle. This interaction triggers enzyme aggregation and proteotoxic stress, culminating death. specific has yet be fully elucidated. recognized sparked numerous investigations into role tumorigenesis cancer therapy. In this review, we summarized current knowledge on metabolism link cancer. Furthermore, delineated mechanisms roles cuproptosis-related genes Finally, offered comprehensive discussion most recent advancements ionophores nanoparticle delivery systems utilize as cutting-edge strategy for treatment.
Language: Английский
Citations
11
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 174, P. 116574 - 116574
Published: April 8, 2024
Gastrointestinal (GI) cancer is one of the most severe types cancer, with a significant impact on human health worldwide. Due to urgent demand for more effective therapeutic strategies against GI cancers, novel research metal ions treating cancers has attracted increasing attention. Currently, accumulating relationship between and therapy, several have been discovered induce cell death. In particular, three modes death, including ferroptosis, cuproptosis, calcicoptosis, become focal points in field cancer. Meanwhile, other also found trigger death through various mechanisms. Accordingly, this review focuses mechanisms ion-induced hoping provide theoretical support further therapies.
Language: Английский
Citations
9
Neoplasia, Journal Year: 2025, Volume and Issue: 61, P. 101125 - 101125
Published: Feb. 3, 2025
Language: Английский
Citations
1
Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)
Published: Oct. 18, 2023
Cuproptosis is a unique type of cell death that may influence tumour formation by targeting lipoylated tricarboxylic acid cycle proteins. Solute carrier family 31 member 1 (SLC31A1), an important copper transporter, influences dietary absorption in the membrane. However, various SLC31A1 properties pan-cancer profiles remain unknown. This study investigated role human malignancies and analysed its prognostic value. Raw data were obtained from The Cancer Genome Atlas database processed using numerous internet databases, including UALCAN, GEPIA, cBioPortal, TIMER2.0, Human Protein Atlas. expression was found to be elevated cervical, endometrial, breast cancers compared normal tissues, but reduced clear renal carcinoma, liver hepatocellular lung adenocarcinoma. Furthermore, strongly associated with overall survival disease-free several cancers. gene mutations methylations identified 33 positively correlated immune cells infiltration data. Single-cell sequencing revealed play key roles DNA repair, damage, proliferation. These findings lead better understanding suggest could viable predictive biomarker, particularly gynaecological
Language: Английский
Citations
22
Frontiers in Genetics, Journal Year: 2022, Volume and Issue: 13
Published: Oct. 18, 2022
As a key copper homeostasis-related molecule, lipoyltransferase 1 (LIPT1) is an essential enzyme for the activation of mitochondrial 2-ketoacid dehydrogenase, participating in fatty acylation. However, biological significances LIPT1 pan-cancer are unclear. Here, we comprehensively analyzed functional characteristics human cancers and its roles immune response. We found that was down-regulated some cancers. And overexpression associated with favorable prognosis these patients, such as breast cancer, clear cell renal carcinoma, ovarian cancer gastric cancer. also explored mutational status methylation levels Gene enrichment analysis indicated abnormally expressed significantly cells infiltration, B cells, CD8 + T cancer-associated fibroblast cells. The result from single sequencing reflected important regulation several behaviors DNA damage response apoptosis. Taken together, our research could provide comprehensive overview about progression, immune.
Language: Английский
Citations
26
American Journal of Translational Research, Journal Year: 2024, Volume and Issue: 16(3), P. 940 - 954
Published: Jan. 1, 2024
To elucidate the expression levels and prognostic value of Lipoyltransferase 2 (LIPT2) gene in a pan-cancer view.
Language: Английский
Citations
6