Cancers,
Journal Year:
2024,
Volume and Issue:
16(3), P. 647 - 647
Published: Feb. 2, 2024
Copper,
an
essential
element
for
various
biological
processes,
demands
precise
regulation
to
avert
detrimental
health
effects
and
potential
cell
toxicity.
This
paper
explores
the
mechanisms
of
copper-induced
death,
known
as
cuproptosis,
its
disease
implications,
including
cancer
therapy.
Copper
ionophores,
such
elesclomol
disulfiram,
increase
intracellular
copper
levels.
elevation
triggers
oxidative
stress
subsequent
offering
implications
in
Additionally,
ionophores
disrupt
mitochondrial
respiration
protein
lipoylation,
further
contributing
toxicity
death.
Potential
targets
biomarkers
are
identified,
can
be
targeted
those
proteins
trigger
cuproptosis.
The
role
different
cancers
is
discussed
understand
therapies
using
nanomaterials,
chelators.
Furthermore,
explored
through
diseases
Wilson
Menkes
physiological
copper.
Exploring
cuproptosis
presents
opportunity
improve
treatments
copper-related
disorders
cancers,
with
bring
significant
advancements
modern
medicine.
Cancers,
Journal Year:
2024,
Volume and Issue:
16(3), P. 512 - 512
Published: Jan. 24, 2024
Iron
(Fe)
and
copper
(Cu),
essential
transition
metals,
play
pivotal
roles
in
various
cellular
processes
critical
to
cancer
biology,
including
cell
proliferation,
mitochondrial
respiration,
distant
metastases,
oxidative
stress.
The
emergence
of
ferroptosis
cuproptosis
as
distinct
forms
non-apoptotic
death
has
heightened
their
significance,
particularly
connection
with
these
metal
ions.
While
initially
studied
separately,
recent
evidence
underscores
the
interdependence
cuproptosis.
Studies
reveal
a
link
between
accumulation
induction.
This
interconnected
relationship
presents
promising
strategy,
especially
for
addressing
refractory
cancers
marked
by
drug
tolerance.
Harnessing
toxicity
iron
clinical
settings
becomes
crucial.
Simultaneous
targeting
cuproptosis,
exemplified
combination
sorafenib
elesclomol-Cu,
represents
an
intriguing
approach.
Strategies
mitochondria
further
enhance
precision
approaches,
providing
hope
improving
treatment
outcomes
drug-resistant
cancers.
Moreover,
chelators
copper-lowering
agents
established
therapeutic
modalities
exhibits
synergy
that
holds
promise
augmentation
anti-tumor
efficacy
malignancies.
review
elaborates
on
complex
interplay
underlying
mechanisms,
explores
potential
druggable
targets
both
research
settings.
Cell Communication and Signaling,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: May 1, 2024
Copper
plays
vital
roles
in
numerous
cellular
processes
and
its
imbalance
can
lead
to
oxidative
stress
dysfunction.
Recent
research
has
unveiled
a
unique
form
of
copper-induced
cell
death,
termed
cuproptosis,
which
differs
from
known
death
mechanisms.
This
process
involves
the
interaction
copper
with
lipoylated
tricarboxylic
acid
cycle
enzymes,
causing
protein
aggregation
death.
Recently,
growing
number
studies
have
explored
link
between
cuproptosis
cancer
development.
review
comprehensively
examines
systemic
metabolism
copper,
including
tumor-related
signaling
pathways
influenced
by
copper.
It
delves
into
discovery
mechanisms
connection
various
cancers.
Additionally,
suggests
potential
treatments
using
ionophores
that
induce
combination
small
molecule
drugs,
for
precision
therapy
specific
types.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(5), P. e27496 - e27496
Published: March 1, 2024
Copper,
a
vital
trace
element,
orchestrates
diverse
cellular
processes
ranging
from
energy
production
to
antioxidant
defense
and
angiogenesis.
Copper
metabolism
cuproptosis
are
closely
linked
in
the
context
of
human
diseases,
with
particular
focus
on
cancer.
Cuproptosis
refers
specific
type
copper-mediated
cell
death
or
copper
toxicity
triggered
by
disruptions
within
cells.
This
phenomenon
encompasses
spectrum
mechanisms,
such
as
oxidative
stress,
mitochondrial
dysfunction,
endoplasmic
reticulum
perturbations
metal
ion
equilibrium.
Mechanistically,
is
driven
binding
lipoylated
enzymes
tricarboxylic
acid
(TCA)
cycle.
interaction
participates
protein
aggregation
proteotoxic
ultimately
culminating
death.
Targeting
its
associated
pathways
cancer
cells
holds
therapeutic
potential
selectively
targeting
eliminating
cancerous
Strategies
modulate
levels,
enhance
excretion,
interfere
cuproptotic
being
explored
identify
novel
targets
for
therapy
improve
patient
outcomes.
Understanding
relationship
between
malignancies
remains
an
active
area
research.
review
provides
comprehensive
overview
association
metabolism,
homeostasis,
cancers,
explicitly
emphasizing
mechanism
implications
pathogenesis.
Additionally,
we
emphasize
aspects
treatment.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 10, 2024
Glioblastoma
multiforme
(GBM)
is
the
most
common
primary
malignant
brain
tumor
and
known
for
its
challenging
prognosis.
Sonodynamic
therapy
(SDT)
an
innovative
therapeutic
approach
that
shows
promise
in
elimination
by
activating
sonosensitizers
with
low-intensity
ultrasound.
In
this
study,
a
novel
sonosensitizer
synthesized
using
Cu-doped
carbon
dots
(Cu-CDs)
sonodynamic
treatment
of
GBM.
Doping
copper
transforms
into
p-n
type
semiconductor
having
bandgap
1.58
eV,
prolonged
lifespan
10.7
µs,
improved
electron-
hole-separation
efficiency.
The
effect
efficiency
enhanced.
Western
blot
analysis
reveals
Cu-CDs
induces
biological
response
leading
to
cell
death,
termed
as
cuproptosis.
Specifically,
upregulate
dihydrosulfanyl
transacetylase
expression,
thereby
establishing
synergistic
against
death
when
combined
SDT.
Furthermore,
exhibit
excellent
permeability
through
blood-brain
barrier
potent
anti-tumor
activity.
Importantly,
effectively
impede
growth
glioblastoma
tumors
prolong
survival
mice
bearing
these
tumors.
This
study
provides
support
application
carbon-based
nanomaterials
therapy.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(4), P. 472 - 472
Published: Feb. 6, 2024
Numerous
nutritional
factors
increase
the
risk
of
hepatocellular
carcinoma
(HCC)
development.
The
dysregulation
zinc,
copper,
and
selenium
homeostasis
is
associated
with
occurrence
HCC.
impairment
these
essential
trace
elements
results
in
oxidative
stress,
DNA
damage,
cell
cycle
progression,
angiogenesis,
finally
leading
to
hepatocarcinogenesis.
These
can
affect
microenvironment
carrier
proteins
for
zinc
copper
selenium-containing
enzymes
play
important
roles
prevention
or
progression
enhance
alleviate
chemosensitivity
anticancer
agents
patients
may
other
each
other.
Novel
types
death
including
ferropotosis
cupropotosis
are
also
Therapeutic
strategies
HCC
that
target
have
been
developed
vitro
vivo
studies.
use
zinc-,
copper-
selenium-nanoparticles
has
considered
as
novel
therapeutic
indicate
become
promising
targets
clinical
application
an
urgent
unmet
requirement.
This
review
article
highlights
correlation
between
development
summarizes
current
trends
on
pathogenesis
