Vaccine, Journal Year: 2024, Volume and Issue: 42(26), P. 126355 - 126355
Published: Sept. 10, 2024
Language: Английский
EBioMedicine, Journal Year: 2024, Volume and Issue: 105, P. 105203 - 105203
Published: June 18, 2024
Hybrid immunity to SARS-CoV-2, resulting from both vaccination and natural infection, remains insufficiently understood in paediatric populations, despite increasing rates of breakthrough infections among vaccinated children.
Language: Английский
Citations
3
Viruses, Journal Year: 2023, Volume and Issue: 15(4), P. 844 - 844
Published: March 25, 2023
Vaccine efficacy against SARS-CoV-2 could be compromised by the emergence of variants and it is important to study how impacts booster vaccination regime. We investigated humoral T cell responses longitudinally in vaccinated uninfected (n = 25) post-COVID-19 individuals 8), those who had received a BNT162b2 following complete two-doses regimes either (homologous) 14) or ChAdOx1-S (heterologous) 15) vaccines, means pseudovirus neutralization test QuantiFERON assay. Vaccinated showed higher neutralizing antibodies with longer durability wild type (WT) Omicron spikes, but demonstrated similar declining compared vaccinated. Two doses induced WT than for six months. The confers greater response WT, cross-neutralizing antibody homologous group heterologous group. Breakthrough infection 11) significantly increased antibody, remained low. Our data may impact government public health policy regarding administration mix-and-match where both can employed should there shortages certain vaccines.
Language: Английский
Citations
7
Modern Rheumatology Case Reports, Journal Year: 2023, Volume and Issue: 8(1), P. 153 - 158
Published: July 25, 2023
ABSTRACT Eosinophilic granulomatosis with polyangiitis (EGPA) is a complex multifactorial disease that results in multisystemic inflammation of the small- and medium-sized arteries. The exact pathogenesis this syndrome poorly understood, but it postulated to result from combination eosinophilic dysfunction, genetic predisposition, development autoantibodies after exposure an unknown stimulus. We describe case new-onset EGPA following third dose Pfizer-BioNTech mRNA vaccine infection-naive middle-aged man background history allergic respiratory symptoms. patient developed acute onset mononeuritis multiplex, pauci-immune glomerulonephritis, leucocytoclastic vasculitis 10 days receiving booster dose. His laboratory markers including eosinophil count, antineutrophil cytoplasmic antibodies, renal function tests improved markedly initiation pulse steroid therapy rituximab infusion. However, his peripheral muscle weakness neuropathic pain did not respond initial later intravenous cyclophosphamide immunoglobulin. To best our knowledge, fourth report post-coronavirus 2019 vaccination precipitation EGPA. All reported cases were patients previous manifestations who received mRNA-based coronavirus vaccines, all multiplex at presentation. Despite few post-vaccination autoimmune phenomena, temporal association between administration does indicate causality, given mass programmes employed. novel use platform delivery necessitates vigilant monitoring by scientific committee.
Language: Английский
Citations
7
mBio, Journal Year: 2023, Volume and Issue: 14(5)
Published: Sept. 1, 2023
Defining correlates of protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine breakthrough infection informs policy for booster doses and future designs. Existing studies demonstrate humoral protection, but the role T cells in is still unclear. In this study, we explore antibody cell immune responses associated with Delta variant a well-characterized cohort UK Healthcare Workers (HCWs). We evidence to support CD4+ CD8+ as well antibodies infection. addition, our results suggest potential cross-reactive breakthrough.
Language: Английский
Citations
7
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 13
Published: Jan. 9, 2023
Background A third mRNA vaccine booster is recommended to improve immunity against SARS-CoV-2 in kidney transplant recipients (KTRs). However, the Ancestral strain and Delta Omicron variants elicited by dose of inactivated KTRs remains unknown. Methods The blood parameters related cells count, hepatic function, heart injury were explored clinically from laboratory examinations. specific antibody IgG titer was detected using an enzyme-linked immunosorbent assay. Cellular analyzed interferon-γ immunospot Results results showed that there no severe adverse effects apparent changes clinical biomarkers healthy volunteers (HVs) after homologous booster. significantly increased anti-Ancestral-spike-trimer-IgG anti-Ancestral-receptor binding domain (RBD)-IgG titers HVs compared with second vaccination. anti-Delta-RBD-IgG anti-Omicron-RBD-IgG lower than anti-Ancestral-RBD-IgG dose. Notably, only 25.6% (10/39) 10.3% (4/39) had seropositivity for booster, which (anti-Delta-RBD-IgG: 100%, anti-Omicron-RBD-IgG: 77.8%). nucleocapsid protein spike T cell frequency not dose, HVs. Moreover, 33.3% (12/36), 14.3% (3/21) positive spike-specific cells, (Ancestral: 80.8%, Delta: 53.8%, Omicron: 57.7%). Conclusions may increase humoral KTRs, while cellular still poor KTRs.
Language: Английский
Citations
5
medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown
Published: Feb. 17, 2023
ABSTRACT T cell correlates of protection against SARS-CoV-2 infection after vaccination (‘vaccine breakthrough’) are incompletely defined, especially the specific contributions CD4+ and CD8+ cells. We studied 279 volunteers in Protective Immunity from Cells Healthcare Workers (PITCH) UK study, including 32 cases (with positive testing two vaccine doses during Delta-dominant era) 247 controls (no test nor anti-nucleocapsid seroconversion this period). 28 days second vaccination, before all breakthroughs occurred, had lower ancestral S- RBD-specific immunoglobulin G titres S1- S2-specific interferon gamma (IFNγ) responses compared with controls. In a subset matched controls, IFNγ tumour necrosis factor to Delta S peptides reduced versus Our findings support protective role for cells breakthrough infection.
Language: Английский
Citations
4
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: April 21, 2023
Introduction COVID-19 vaccines based on mRNA have represented a revolution in the biomedical research field. The initial two-dose vaccination schedule generates potent humoral and cellular responses, with massive protective effect against severe death. Months after this vaccination, levels of antibodies SARS-CoV-2 waned, promoted recommendation third dose. Methods We performed an integral longitudinal study immunological responses triggered by booster mRNA-1273 cohort health workers previously vaccinated two doses BNT162b2 vaccine at University Hospital La Paz located Madrid, Spain. Circulating SARS-CoV-2-specific reactions, ex vivo restimulation both T B cells (cytokines production, proliferation, class switching), been analyzed. Importantly, all along these studies, analyses comparing naïve subjects recovered from COVID-19, addressing influence previous infection SARS-CoV-2. Furthermore, as injection dose was contemporary to rise Omicron BA.1 variant concern, T- B-cell-mediated comparatively analyzed response variant. Results All indicated that differential due were balanced following boost. increase circulating dropped 6 months, whereas T-cell-mediated more stable time. Finally, features dampened particularly late vaccination. Conclusion This work represents follow-up for almost 1.5 years, analyzing manner prime-boost mRNA-based COVID-19.
Language: Английский
Citations
4
Journal of Medical Virology, Journal Year: 2023, Volume and Issue: 95(8)
Published: Aug. 1, 2023
Abstract Coronavirus disease‐2019 (COVID‐19) bivalent ancestral/Omicron messenger RNA (mRNA) booster vaccinations became available to boost and expand the immunity against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) Omicron infections. In a prospective cohort study including 59 healthcare workers, we assessed SARS‐CoV‐2 ancestral BA.5‐specific neutralizing antibody T‐cell responses in previously infected infection‐naive individuals. Also, effect of an BA.1 mRNA vaccination on these immune responses. 10 months after previous monovalent vaccinations, S1‐specific anti‐RBD IgG remained detectable most individuals infection was associated with increased responses, IgG, BA.5 neutralization activity receiving vaccination. An addition vaccination, led higher ratio strain compared no recent infection. conclusion, persist for up increases also induces cross‐neutralization activity. Finally, our data indicate that hybrid is improved preservation immunity.
Language: Английский
Citations
4
The Journal of Infectious Diseases, Journal Year: 2024, Volume and Issue: 230(3), P. 635 - 644
Published: May 14, 2024
Vaccines and vaccine boosting have blunted excess morbidity mortality from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in older nursing home residents (NHR). However, the impact of repeated vaccination on T-cell response based biological sex prior NHR remain understudied.
Language: Английский
Citations
1
Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)
Published: Nov. 27, 2022
Abstract Longitudinal studies have revealed large interindividual differences in antibody responses induced by SARS-CoV-2 mRNA vaccines. Thus, we performed a comprehensive analysis of adaptive immune three doses the BNT162b2 The spike-specific CD4 + T cells, CD8 cells and serum IgG, neutralization capacities two vaccines declined 6 months later. 3 rd dose increased spike IgG neutralizing against wild-type Omicron spikes to higher levels than 2 nd dose, this was supported memory B cell responses, which gradually after were further enhanced dose. moderately frequencies but remained unchanged. reactive 1.3-fold fewer those spike. early responsiveness T, circulating follicular helper peripheral correlated with booster vaccination, also associated responses. These findings highlight importance evaluating cellular optimize future vaccine strategies.
Language: Английский
Citations
7