Protective role of SARS-CoV-2 anti-S IgG against breakthrough infections among European healthcare workers during pre and post-Omicron surge—ORCHESTRA project

Infection, Journal Year: 2024, Volume and Issue: 52(4), P. 1347 - 1356

Published: Feb. 7, 2024

Anti SARS-CoV-2 vaccination initially showed high effectiveness in preventing COVID-19. However, after the surge of variants concern, dropped. Several studies investigated if this was related to decrease humoral response over time; however, issue is still unclear. The aim study understand whether anti-S IgG levels can be used predict breakthrough infection risk and define timing for further booster doses administration.

Language: Английский

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Optimal time for COVID-19 vaccination in rituximab-treated dermatologic patients

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: March 15, 2023

Background By depleting circulating B lymphocytes, rituximab time-dependently suppresses coronavirus disease 2019 (COVID-19) vaccines’ humoral immunogenicity for a prolonged period. The optimal time to vaccinate rituximab-exposed immune-mediated dermatologic (IMDD) patients is currently unclear. Objective To estimate the vaccination timeframe that equalized occurrence of outcomes between and rituximab-naïve IMDD patients. Methods This retrospective cohort study recruited age-matched subjects tested severe acute respiratory syndrome 2 (SARS-CoV-2)-specific immunity post-vaccination. Baseline clinical immunological data (i.e., immunoglobulin levels, lymphocyte immunophenotyping) SARS-CoV-2-specific levels were extracted. compared percentages who produced neutralizing antibodies (seroconversion rates, SR) IgG among seroconverters. first analyzed using multiple regressions adjusted effects corticosteroid use, steroid-spearing agents, pre-vaccination status IgM total, naïve, memory lymphocytes) identify rituximab-related outcomes. outcome differences with 95% confidence interval (CI) groups calculated, starting by including every subject then narrowing down those longer rituximab-to-vaccination intervals (≥3, ≥6, ≥9, ≥12 months). desirable cut-off performances <25% inferiority observed subgroups subjects, positive likelihood ratio (LR+) corresponding ≥2. Findings Forty-five 90 rituximab-naive included. regression analysis demonstrated negative association exposure SR but not levels. Nine-month fulfilled our prespecified diagnostic performance (SR difference group [95%CI]: -2.6 [-23.3, 18.1], LR+: 2.6) coincided repopulation naïve lymphocytes in these Conclusions Nine months maximize benefits COVID-19 vaccines while avoiding unnecessary delay treatment

Language: Английский

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Genome‐wide association studies of response and side effects to the BNT162b2 vaccine in Italian healthcare workers: Increased antibody levels and side effects in carriers of the HLA‐A*03:01 allele

HLA, Journal Year: 2023, Volume and Issue: 102(6), P. 707 - 719

Published: July 19, 2023

The remarkable variability of response to vaccines against SARS-CoV-2 is apparent. present study aims estimate the extent which host genetic background contributes this in terms immune and side effects following administration BNT162b2 vaccine. We carried out a genome wide association (GWAS) by genotyping 873 Italian healthcare workers who underwent anti-SARS-CoV-2 vaccination with vaccine for whom information about spike antibodies titers were available. GWAS revealed significant between HLA locus Spike level at 2 months first dose (SNP: rs1737060; p = 9.80 × 10-11 ). In particular, we observed positive antibody levels presence HLA-A*03:01 allele. same allele was found associated 2-2.4-fold increased risk experiencing specific such as fever, chills myalgia 1.5-1.8-fold joint pain, nausea, fatigue, headache asthenia, independently age sex. This confirms that heterogeneity its are least partially influenced variants. information, integrated individual biological lifestyle-related correlates, could be use definition algorithms aimed identification subjects additional doses would particularly beneficial maintain immunity virus.

Language: Английский

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Innovative methods for dissemination of research results during a Pandemic: A Game- Changing Approach in the ORCHESTRA project

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Background Effective communication is crucial during pandemics to mitigate fear and promote acceptance of public health measures. However, the COVID-19 pandemic revealed significant challenges, including an overwhelming volume scientific information, poor quality control, a rise in false or misleading data. Peer-reviewed publications often faced criticism for fast-tracked review processes, with pre-prints contributing increased retraction rate. These issues undermined trust implementation evidence-based Methods The Horizon2020 ORCHESTRA project developed Global Guidance Group (CGGG), external expert evaluation mechanism, critically assess ensure dissemination accurate relevant findings. CGGG employed Delphi method systematically achieve consensus on research outputs. Findings were tailored stakeholders such as policymakers, community, general public. Results evaluated over 100 peer-reviewed publications, achieving average impact factor 8.7 ensuring use enhanced rigor process improved targeting strategies, addressing gaps engagement pandemic. Conclusions project’s experience highlights value evaluation, supported by consensus-building approaches like method, crises. Broader adoption similar mechanisms could improve integrity effectiveness bolstering policymaking future emergencies.

Language: Английский

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Global spatio-temporal distribution of coronavirus disease 2019 vaccine hesitancy between 2020 and 2022: A meta-analysis

Vaccine, Journal Year: 2025, Volume and Issue: 53, P. 126933 - 126933

Published: March 3, 2025

Language: Английский

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A pilot study on the effect of video games on ASD children's mental health and behaviour and oral health management in Syria – 2023

Oral & Implantology, Journal Year: 2025, Volume and Issue: 17(2), P. 117 - 126

Published: April 16, 2025

This pilot study investigates the impact of video games on mental health and behavior children with autism spectrum disorder (ASD) in Syria. With increasing prevalence ASD growing popularity games, understanding potential benefits risks gaming for is crucial. The explores whether can serve as a therapeutic tool or if they contribute to behavioral deterioration addiction. A sample 50 aged 6 12 years, diagnosed according ICD-11 criteria, participated study. Data were collected through structured questionnaires completed by parents, assessing habits, behavioural changes, level game addiction using Internet Gaming Disorder Scale - Modified Short Form (IGDS9-SF). also evaluated effects replacing violent repetitive more creative interactive options, such Minecraft Super Mario Bros.Results indicated that 90% preferred playing over other activities, boys showing higher preference violence fighting games. Approximately 54% exhibited signs addiction, while 14% classified fully addicted. During gameplay, 74% displayed negative behaviors, increased aggression reduced communication. However, after switching constructive significant improvements communication, social interaction, control observed.The concludes offer ASD, including improved skills, anxiety, enhanced problem-solving abilities, pose risks, particularly terms outcomes. type played critical factor determining ASD. careful selection promote creativity, cooperation, cognitive development help harness positive aspects mitigating its harms. highlights need further research into game-based interventions tailored specifically aiming balance excessive gaming.

Language: Английский

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Temporal correlations between RBD-ACE2 blocking and binding antibodies to SARS-CoV-2 variants in CoronaVac-vaccinated individuals and their persistence in COVID-19 patients

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: May 6, 2025

Abstract Antibodies play a crucial role in protection against SARS-CoV-2. Understanding the correlation between binding and functional antibodies is essential to determine whether antibody levels can reliably predict neutralizing activity. We assessed responses 111 individuals vaccinated with inactivated vaccine CoronaVac COVID-19 patients Thailand. Plasma of ACE2-blocking targeting receptor-binding domain (RBD) SARS-Co-V2 variants were measured before vaccination at 14 28 days after second dose using multiplex surrogate virus neutralization test. Anti-spike anti-nucleocapsid quantified by electrochemiluminescence immunoassay, anti-RBD IgG ELISA. After vaccination, blocking, anti-spike, increased but declined rapidly within month, whereas persisted. Blocking anti-spike correlated day post-vaccination not 28. In patients, correlations moderate 14, stronger Correlations weaker for Omicron subvariants than ancestral strain non-Omicron variants. The weak blocking suggests might These findings highlight temporal nature CoronaVac-induced immunity need booster doses variant-adapted vaccine.

Language: Английский

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Evaluation of Anti-SARS-CoV-2 IgG Responses in a Clinical Study of a Biosimilar Candidate to Denosumab Using Singlicate Analysis

Drugs in R&D, Journal Year: 2025, Volume and Issue: unknown

Published: May 23, 2025

Language: Английский

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Multimorbidity and Serological Response to SARS-CoV-2 Nine Months after 1st Vaccine Dose: European Cohort of Healthcare Workers—Orchestra Project

Vaccines, Journal Year: 2023, Volume and Issue: 11(8), P. 1340 - 1340

Published: Aug. 8, 2023

Understanding antibody persistence concerning multimorbidity is crucial for vaccination policies. Our goal to assess the link between and serological response SARS-CoV-2 nine months post-first vaccine. We analyzed Healthcare Workers (HCWs) from three cohorts Italy, one each Germany, Romania, Slovakia, Spain. Seven groups of chronic diseases were analyzed. included 2941 HCWs (78.5% female, 73.4% ≥ 40 years old). Multimorbidity was present in 6.9% HCWs. The prevalence condition ranged 1.9% (cancer) 10.3% (allergies). Two regression models fitted, considering conditions other whether had ≥2 groups. HCWs, higher 9-months post-vaccine anti-S levels significantly associated with having received doses vaccine (RR = 2.45, CI 1.92–3.13) a prior COVID-19 infection 2.30, 2.15–2.46). Conversely, lower age 0.94, 0.91–0.96), more time since last dose 0.95, 0.94–0.96), 0.89, 0.80–1.00). Hypertension 0.87, 0.80–0.95). vaccines inadequate individuals multimorbidity.

Language: Английский

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How European Research Projects Can Support Vaccination Strategies: The Case of the ORCHESTRA Project for SARS-CoV-2

Vaccines, Journal Year: 2023, Volume and Issue: 11(8), P. 1361 - 1361

Published: Aug. 14, 2023

ORCHESTRA (“Connecting European Cohorts to Increase Common and Effective Response To SARS-CoV-2 Pandemic”) is an EU-funded project which aims help rapidly advance the knowledge related prevention of infection management COVID-19 its long-term sequelae. Here, we describe early results this project, focusing on strengths multiple, international, historical prospective cohort studies highlighting those are potential relevance for vaccination strategies, such as necessity a vaccine booster dose after primary course in hematologic cancer patients solid organ transplant recipients elicit higher antibody titer, protective effect severe clinical manifestation emergence post-COVID-19 conditions. Valuable data regarding epidemiological variations, risk factors sequelae, efficacy different subpopulations can support further defining public health policies.

Language: Английский

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