SARS-CoV-2 Infection Risk by Vaccine Doses and Prior Infections Over 24 Months: ProHEpiC-19 Longitudinal Study DOI Creative Commons
Pere Torán‐Monserrat, Noemí Lamonja-Vicente, Anna Costa-Garrido

et al.

JMIR Public Health and Surveillance, Journal Year: 2024, Volume and Issue: 10, P. e56926 - e56926

Published: Nov. 22, 2024

Abstract Background As the vaccination campaign against COVID-19 progresses, it becomes crucial to comprehend lasting effects of on safeguarding new infections or reinfections. Objective This study aimed assess risk SARS-CoV-2 based number vaccine doses, prior infections, and other clinical characteristics. Methods We defined a cohort 800 health care workers in 24-month (March 2020 December 2022) northern Barcelona determine by SARS-CoV-2. used extended Cox models, specifically Andersen-Gill (AG) Prentice-Williams-Peterson, we examined infections. The AG model incorporated variables such as sex, age, job title, chronic conditions, Additionally, 2 Prentice-Williams-Peterson models were adjusted, one for those individuals with no 1 infection another 3 both same covariates model. Results participants (n=605, 75.6% women) received 1, 2, 3, 4 doses vaccine. Compared who unvaccinated, significantly reduced ( P <.001) 66%, 81%, 89%, 99%, respectively. Unit increase 75% <.001). When separating previous was 61% =.02), 88%, 93%, 99% In contrast, reduction only significant fourth dose, at 98% diseases increased 28%‐31% 0‐1 Conclusions suggests that status contribute immunity, supporting effectiveness reducing reinfection up 24 months after follow-up from onset pandemic. These insights our understanding long-term immunity dynamics inform strategies mitigating impact COVID-19.

Language: Английский

The impact of the COVID-19 pandemic on musculoskeletal disorders-related sick leave among healthcare workers: a retrospective analysis of Slovenian national data DOI Creative Commons
Dorjana Zerbo Šporin, Žiga Kozinc,

Ticijana Prijon

et al.

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 6, 2025

Musculoskeletal disorders (MSDs) are one of the main causes health-related absenteeism. MSDs were a known problem among healthcare workers (HCWs) even before COVID-19. The pandemic, with its associated stresses and changes in working conditions, may have influenced incidence duration MSDs-related sick leave (SL) HCWs. aim this study was to compare SL HCWs during COVID-19 focus on differences between age gender groups. A retrospective analysis conducted using Slovenian national data work-related within NACE Rev. 2 "Human health activities" for 2019, 2020, 2021, categorized by age. found that older HCWs, particularly women, consistently had higher than their younger counterparts. However, more common men, while average longer women. On other hand, decreased substantially increased. dynamics related complex several factors, including challenges posed pandemic. Healthcare managers should implement tailored strategies address absenteeism specific groups promote healthier workforce ensure resilient system crises.

Language: Английский

Citations

1
SARS-CoV-2 seroreversion and all-cause mortality in nursing home residents and staff post-primary course vaccination in Belgium between February and December 2021 DOI
Eline Meyers, Liselore De Rop,

Ellen Deschepper

et al.

Vaccine, Journal Year: 2025, Volume and Issue: 51, P. 126865 - 126865

Published: Feb. 20, 2025

Language: Английский

Citations

0
Changes in cerebrovascular reactivity within functional networks in older adults with long-COVID DOI Creative Commons

Jessica Pommy,

Alexander D. Cohen,

Amarpreet Mahil

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: March 26, 2025

Introduction Cognitive symptoms are reported in the vast majority of individuals with long-COVID and there is growing support to suggest neurovascular mechanisms may play a role. Older adults at increased risk for developing complications associated COVID-19, including heightened cognitive decline. Cerebrovascular Reactivity (CVR), marker health, has been linked age related decline role long-COVID, however, this not yet explored. Methods The present study examined group differences CVR 31 older compared cognitively unimpaired without symptoms. Follow up analyses were conducted examine how was both subjective neuropsychological (NP) test performance. A subject-specific approach, Distribution-Corrected Z-scores (DisCo-Z), used. Results Analyses revealed demonstrated significantly greater incidence extreme clusters within brain (&gt;100 voxels) functional networks thought drive attention executive function. Extreme positive positively number negatively correlated NP Discussion These findings among first provide link between functioning changes relevant aging mechanistic studies long-COVID.

Language: Английский

Citations

0
Innovative methods for dissemination of research results during a Pandemic: A Game- Changing Approach in the ORCHESTRA project DOI Creative Commons
Daniele Pantano, Robert J. Davis, Silvia Vitali

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Abstract Background Effective communication is crucial during pandemics to mitigate fear and promote acceptance of public health measures. However, the COVID-19 pandemic revealed significant challenges, including an overwhelming volume scientific information, poor quality control, a rise in false or misleading data. Peer-reviewed publications often faced criticism for fast-tracked review processes, with pre-prints contributing increased retraction rate. These issues undermined trust implementation evidence-based Methods The Horizon2020 ORCHESTRA project developed Global Guidance Group (CGGG), external expert evaluation mechanism, critically assess ensure dissemination accurate relevant findings. CGGG employed Delphi method systematically achieve consensus on research outputs. Findings were tailored stakeholders such as policymakers, community, general public. Results evaluated over 100 peer-reviewed publications, achieving average impact factor 8.7 ensuring use enhanced rigor process improved targeting strategies, addressing gaps engagement pandemic. Conclusions project’s experience highlights value evaluation, supported by consensus-building approaches like method, crises. Broader adoption similar mechanisms could improve integrity effectiveness bolstering policymaking future emergencies.

Language: Английский

Citations

0
The impact of COVID-19 on pulmonary, neurological, and cardiac outcomes: evidence from a Mendelian randomization study DOI Creative Commons

Pooja U. Shenoy,

Hrushikesh Udupa,

Jyothika KS

et al.

Frontiers in Public Health, Journal Year: 2023, Volume and Issue: 11

Published: Dec. 14, 2023

Background Long COVID is a clinical entity characterized by persistent health problems or development of new diseases, without an alternative diagnosis, following SARS-CoV-2 infection that affects significant proportion individuals globally. It can manifest with wide range symptoms due to dysfunction multiple organ systems including but not limited cardiovascular, hematologic, neurological, gastrointestinal, and renal organs, revealed observational studies. However, causal association between the genetic predisposition COVID-19 many post-infective abnormalities in long remain unclear. Methods Here we employed Mendelian randomization (MR), robust epidemiological approach, investigate potential associations symptoms, namely pulmonary (pneumonia airway infections bronchitis, emphysema, asthma, rhinitis), neurological (headache, depression, Parkinson’s disease), cardiac (heart failure chest pain) chronic fatigue. Using two-sample MR, leveraged data from large genome-wide study various disorder-specific datasets. Results This analysis was significantly causally linked increased risk developing pneumonia, infections, headache, heart failure. also showed strong positive correlation fatigue, frequently observed symptom patients. our findings on disease, pain were inconclusive. Conclusion Overall, these provide valuable insights into underpinnings its diverse symptoms. Understanding may aid better management treatment patients, thereby alleviating substantial burden it poses global socioeconomic systems.

Language: Английский

Citations

5
The impact of SARS-CoV-2 on healthcare workers of a large University Hospital in the Veneto Region: risk of infection and clinical presentation in relation to different pandemic phases and some relevant determinants DOI Creative Commons
Filippo Liviero,

Anna Volpin,

Patrizia Furlan

et al.

Frontiers in Public Health, Journal Year: 2023, Volume and Issue: 11

Published: Nov. 30, 2023

Aim The aim of this study is to evaluate the incidence SARS-CoV-2 infection and prevalence COVID-19-related symptoms in relation pandemic phases some relevant variables a cohort 8,029 HCWs from one largest Italian University Hospitals. Methods A single-center retrospective was performed on data collected during surveillance HCWs. Cox’s multiple regression estimate hazard ratios infection. Logistic multivariate used assess risk asymptomatic infections onset most frequent symptoms. All analyses were adjusted for sociodemographic occupational factors, phases, vaccination status, previous infections. Results total 3,760 resulted positive (2.0%–18.6% across five phases). rate 7.31 cases per 10,000 person-days, significantly lower phase 1 higher 4 5, compared 3. Younger HCWs, healthcare personnel, unvaccinated subjects showed Overall, 24.5% infections, with probability men, physicians, tested screening, fully vaccinated, those clinical presentation changed over status emergence new variants. Conclusion screening activities allowed early detection cases, limiting epidemic clusters inside hospital wards. reduced symptomatic demonstrating again its paramount value as preventive tool public health.

Language: Английский

Citations

4
Polypharmacy and Antibody Response to SARS-CoV-2 Vaccination in Residents of Long-Term Care Facilities: The GeroCovid Vax Study DOI
Caterina Trevisan, Labjona Haxhiaj, Alba Malara

et al.

Drugs & Aging, Journal Year: 2023, Volume and Issue: 40(12), P. 1133 - 1141

Published: Nov. 8, 2023

Language: Английский

Citations

3
SARS-CoV-2 Infection Risk by Vaccine Doses and Prior Infections Over 24 Months: ProHEpiC-19 Longitudinal Study DOI Creative Commons
Pere Torán‐Monserrat, Noemí Lamonja-Vicente, Anna Costa-Garrido

et al.

JMIR Public Health and Surveillance, Journal Year: 2024, Volume and Issue: 10, P. e56926 - e56926

Published: Nov. 22, 2024

Abstract Background As the vaccination campaign against COVID-19 progresses, it becomes crucial to comprehend lasting effects of on safeguarding new infections or reinfections. Objective This study aimed assess risk SARS-CoV-2 based number vaccine doses, prior infections, and other clinical characteristics. Methods We defined a cohort 800 health care workers in 24-month (March 2020 December 2022) northern Barcelona determine by SARS-CoV-2. used extended Cox models, specifically Andersen-Gill (AG) Prentice-Williams-Peterson, we examined infections. The AG model incorporated variables such as sex, age, job title, chronic conditions, Additionally, 2 Prentice-Williams-Peterson models were adjusted, one for those individuals with no 1 infection another 3 both same covariates model. Results participants (n=605, 75.6% women) received 1, 2, 3, 4 doses vaccine. Compared who unvaccinated, significantly reduced ( P <.001) 66%, 81%, 89%, 99%, respectively. Unit increase 75% <.001). When separating previous was 61% =.02), 88%, 93%, 99% In contrast, reduction only significant fourth dose, at 98% diseases increased 28%‐31% 0‐1 Conclusions suggests that status contribute immunity, supporting effectiveness reducing reinfection up 24 months after follow-up from onset pandemic. These insights our understanding long-term immunity dynamics inform strategies mitigating impact COVID-19.

Language: Английский

Citations

0