Environmental Enrichment for Stroke and Traumatic Brain Injury: Mechanisms and Translational Implications DOI

Luwei Nie,

Jinxin He,

Junmin Wang

et al.

Comprehensive physiology, Journal Year: 2023, Volume and Issue: unknown, P. 5291 - 5323

Published: Dec. 29, 2023

Abstract Acquired brain injuries, such as ischemic stroke, intracerebral hemorrhage (ICH), and traumatic injury (TBI), can cause severe neurologic damage even death. Unfortunately, currently, there are no effective safe treatments to reduce the high disability mortality rates associated with these injuries. However, environmental enrichment (EE) is an emerging approach treating rehabilitating acquired injuries by promoting motor, sensory, social stimulation. Multiple preclinical studies have shown that EE benefits functional recovery, including improved motor cognitive function psychological mediated complex protective signaling pathways. This article provides overview of enriched environment protocols used in animal models ICH, TBI, well relevant clinical studies, a particular focus on stroke. Additionally, we explored animals stroke TBI exposed alone or combination multiple drugs other rehabilitation modalities. Finally, discuss potential applications future therapy molecular cellular changes caused rodents TBI. aims advance research for injury. © 2024 American Physiological Society. Compr Physiol 14:5291‐5323, 2024.

Language: Английский

Bioinformatics Analysis of Programmed Cell Death in Spinal Cord Injury DOI
Xuegang He, Bo Deng, Miao Ma

et al.

World Neurosurgery, Journal Year: 2023, Volume and Issue: 177, P. e332 - e342

Published: June 20, 2023

Language: Английский

Citations

6
Cystatin C Attenuates Perihematomal Secondary Brain Injury by Inhibiting the Cathepsin B/NLRP3 Signaling Pathway in a Rat Model of Intracerebral Hemorrhage DOI
Yongfang Zhou, Wentao Dong, Likun Wang

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 61(11), P. 9646 - 9662

Published: April 27, 2024

Language: Английский

Citations

1
Intracerebral Hemorrhage-Induced Brain Injury: the Role of Lysosomal-Associated Transmembrane Protein 5 DOI
Wei Hua, Shuainan Ma,

Yuxin Pang

et al.

Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 60(12), P. 7060 - 7079

Published: Aug. 1, 2023

Language: Английский

Citations

3
The role of pyroptosis in incomplete immune reconstitution among people living with HIV：Potential therapeutic targets DOI Creative Commons
Chao Xia, Xue Zhang, Vijay Harypursat

et al.

Pharmacological Research, Journal Year: 2023, Volume and Issue: 197, P. 106969 - 106969

Published: Oct. 21, 2023

Globally, HIV infection causes significant morbidity and mortality, is a major public health problem. Despite the fact that widespread use of antiretroviral therapy (ART) has substantially altered natural history from originally being universally lethal disease to now chronic medical condition for those taking appropriate treatment, approximately 10-40% people living with (PLWH) who take effective ART maintain long-term viral suppression fail achieve normalization CD4 + T-cell counts. This phenomenon referred as incomplete immune reconstitution or immunological non-response. Although precise mechanisms underlying this outcome have not been elucidated, recent evidence indicates excessive pyroptosis may play crucial role in development reconstitution. Pyroptosis characterized by formation pores cell membrane, rupture, secretion intracellular contents pro-inflammatory cytokines, including IL-1β IL-18. inflammation-induced programmed death leads massive loss T-cells, inflammatory consequences promote sustain Herein, we review possible pathways activated inflammasomes act switches pyroptosis, HIV, well relevance T-cells We also highlight involved reconstitution, thus paving way potential targets treatment

Language: Английский

Citations

3
Environmental Enrichment for Stroke and Traumatic Brain Injury: Mechanisms and Translational Implications DOI

Luwei Nie,

Jinxin He,

Junmin Wang

et al.

Comprehensive physiology, Journal Year: 2023, Volume and Issue: unknown, P. 5291 - 5323

Published: Dec. 29, 2023

Abstract Acquired brain injuries, such as ischemic stroke, intracerebral hemorrhage (ICH), and traumatic injury (TBI), can cause severe neurologic damage even death. Unfortunately, currently, there are no effective safe treatments to reduce the high disability mortality rates associated with these injuries. However, environmental enrichment (EE) is an emerging approach treating rehabilitating acquired injuries by promoting motor, sensory, social stimulation. Multiple preclinical studies have shown that EE benefits functional recovery, including improved motor cognitive function psychological mediated complex protective signaling pathways. This article provides overview of enriched environment protocols used in animal models ICH, TBI, well relevant clinical studies, a particular focus on stroke. Additionally, we explored animals stroke TBI exposed alone or combination multiple drugs other rehabilitation modalities. Finally, discuss potential applications future therapy molecular cellular changes caused rodents TBI. aims advance research for injury. © 2024 American Physiological Society. Compr Physiol 14:5291‐5323, 2024.

Language: Английский

Citations

3