METRNL mitigates oxidative stress and inflammatory drawbacks in ovalbumin/lipopolysaccharide-induced allergic airway diseases via the IKK/IκB/NF-κB signaling pathway

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Abstract This study aimed to examine the potential impacts of METRNL as an antioxidant and anti-inflammatory through IκB kinase/inhibitor nuclear factor-kappa B/nuclear factor-kappa-light-chain signaling pathway on many biomarkers lung structure in rats with bronchial asthma induced by ovalbumin/lipopolysaccharide (OVA/LPS). Forty were randomly divided into four equal groups: control group, vehicle diseased (OVA/LPS) group OVA 2.5 ml/kg intratracheal installation/LPS 1.5 mg/kg intraperitoneally, treated (OVA/LPS + METRNL) at a dose 2 mg/rat/day IV. After 4 weeks, plasma tissues analyzed assess oxidative stress inflammatory markers. Additionally, histological assessment was conducted tissues. Bronchial confirmed when increased levels total serum IgE, cell count, neutrophils, eosinophils, macrophages, lymphocyte counts BAL fluid observed. Moreover, OVA/LPS resulted reduction superoxide dismutase (SOD) while raising malondialdehyde (MDA). Furthermore, it elevated concentrations mediators, including tumor necrosis factor-alpha (TNF-alpha), interleukin 17 (IL-17), transforming growth factor beta (TGF-β). The protective effects analyzed. observed are believed result from drug’s properties its action IKK/IκB/NF-κB pathway. investigation indicates that treatment positively improved rats’ biochemical aspects OVA/LPS-induced airway allergic inflammation.

Language: Английский

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Diabetes Mellitus and Associated Vascular Disease: Pathogenesis, Complications, and Evolving Treatments

Advances in Therapy, Journal Year: 2025, Volume and Issue: unknown

Published: April 19, 2025

Diabetes mellitus is a metabolic disorder, characterized by elevated blood sugar levels (hyperglycemia) and insulin dysregulation. This disease associated with morbidity mortality, including significant potential vascular complications. High of hyperglycemia lead to not only reactive oxygen species but also advanced glycation end products, which are detrimental the endothelium reduce protective compounds such as nitric oxide prostacyclin. damage contributes development both macrovascular microvascular The present investigation explores pathophysiological mechanisms diabetic complications evaluates current management strategies, lifestyle modifications, pharmacological treatments, emerging therapies. review underscores importance ongoing progress in diabetes patient education optimal patient-health outcomes quality life for individuals mellitus.

Language: Английский

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Meteorin-like protein (Metrnl): a key exerkine in exercise-mediated cardiovascular health

Archives of Physiology and Biochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 15

Published: April 27, 2025

Cardiovascular diseases (CVDs) remain a leading global cause of mortality, necessitating non‑pharmacological interventions such as exercise. Meteorin‑like protein (Metrnl), an exercise‑induced myokine and adipokine, has emerged critical mediator exercise‑mediated cardiovascular benefits, though its specific mechanisms clinical implications underexplored. This review synthesizes current evidence on Metrnl's role key exerkine in health, focusing regulatory mechanisms, tissue‑specific effects, therapeutic potential for CVD management. A comprehensive analysis preclinical studies was conducted, encompassing molecular, metabolic, anti‑inflammatory pathways linked to Metrnl. Literature from PubMed, Scopus, Web Science systematically reviewed evaluate adaptations. Exercise‑induced Metrnl enhances endothelial function, vascular remodeling, metabolic regulation via AMPK, PPARγ, KIT receptor signaling. It promotes glucose/lipid metabolism, angiogenesis, responses, reducing atherosclerotic risks improving cardiac repair post‑infarction. Clinically, levels correlate with severity, acting biomarker risk stratification. Acute exercise elevates Metrnl, while chronic training effects vary by modality population. Paradoxically, elevated plasma acute events predicts adverse outcomes, whereas reduced conditions (e.g., diabetes, heart failure) reflect dysregulation. bridges benefits health through inter‑organ crosstalk, yet discrepancies exist regulation. Its dual protective stress‑responsive underscores context‑dependent interpretations. Unresolved questions include specificity, tissue autonomy, delivery strategies. is pivotal promising diagnostic CVDs. Translating into applications requires further human trials validate optimize interventions. Harnessing could revolutionize strategies prevention rehabilitation, leveraging exercise's molecular advantages.

Language: Английский

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FAPs orchestrate homeostasis of muscle physiology and pathophysiology

The FASEB Journal, Journal Year: 2024, Volume and Issue: 38(24)

Published: Dec. 13, 2024

As a common clinical manifestation, muscle weakness is prevalent in people with mobility disorders. Further studies of have found that patients present persistent inflammation, loss fibers, fat infiltration, and interstitial fibrosis. Therefore, we propose the concept microenvironment homeostasis, which explains abnormal pathological changes muscles through imbalance homeostasis. And identified an progenitor cell FAP during transition from normal homeostasis to caused by damage diseases. kind pluripotent stem cell, FAPs do not participate myogenic differentiation, but can differentiate into fibroblasts, adipocytes, osteoblasts, chondrocytes. mesenchymal it involved generation extracellular matrix, regulate regeneration, maintain neuromuscular junction. However, disrupted causative factors, activities eventually contribute complex muscles. Targeting mechanisms these changes, appropriate signaling targets for improve even treat In this review, construction microenvironmental find key cells cause after broken. By studying mechanism differentiation apoptosis FAPs, strategy inhibit diseases regeneration.

Language: Английский

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Circulating levels of irisin and Meteorin-like protein in PCOS and its correlation with metabolic parameters

Endokrynologia Polska, Journal Year: 2024, Volume and Issue: unknown

Published: March 19, 2024

Introduction: Research on obesity, which results from excessive food consumption and sedentary lifestyle, has focused increasing energy expenditure. Recently, muscle tissue is being investigated as an endocrine active organ, secreting molecules called myokines. Multiple studies have been performed to assess myokine levels in various disorders, including polycystic ovary syndrome (PCOS) metabolic syndrome. Irisin Meteorin-like protein (Metrnl) are particles which, among others, suggested play important role adipose browning improving insulin sensitivity. Material methods: The study population consisted of 31 women with PCOS 18 healthy individuals. was diagnosed based revised 2003 Rotterdam criteria. anthropometrical, hormonal, biochemical parameters were assessed, oral glucose tolerance test body composition dual X-ray absorptiometry. Serum irisin Metrnl measured by enzyme-linked immunosorbent assay (ELISA). Results: There no differences between the control groups according age, mass index (BMI), waist-to-hip ratio (WHR), fasting glucose, homeostasis model assessment resistance (HOMA-IR), or composition. Assessment concentrations revealed significant women. level negatively correlated BMI, fat mass, concentrations. No relationship found. Conclusions: Although seems be a promising biomarker, inconsistent research limits its value clinical use treatment obesity. not affected population, but it might connected severity disturbances.

Language: Английский

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