Neural Regeneration Research,
Journal Year:
2024,
Volume and Issue:
20(5), P. 1258 - 1276
Published: June 3, 2024
The
central
nervous
system,
information
integration
center
of
the
body,
is
mainly
composed
neurons
and
glial
cells.
neuron
one
most
basic
important
structural
functional
units
with
sensory
stimulation
excitation
conduction
functions.
Astrocytes
microglia
belong
to
cell
family,
which
main
source
cytokines
represents
defense
system
system.
Nerve
cells
undergo
neurotransmission
or
gliotransmission,
regulates
neuronal
activity
via
ion
channels,
receptors,
transporters
expressed
on
nerve
membranes.
Ion
large
transmembrane
proteins,
play
crucial
roles
in
maintaining
homeostasis.
These
channels
are
also
for
control
membrane
potential
secretion
neurotransmitters.
A
variety
cellular
functions
life
activities,
including
regulation
generation
excitation,
occurrence
receptor
potential,
heart
pulsation,
smooth
muscle
peristalsis,
skeletal
contraction,
hormone
secretion,
closely
related
associated
passive
transport.
Two
types
potassium
calcium
various
neurological
disorders,
Alzheimer’s
disease,
Parkinson’s
epilepsy.
Accordingly,
drugs
that
can
affect
these
have
been
explored
deeply
provide
new
directions
treatment
disorders.
In
this
review,
we
focus
different
their
involvement
disorders
such
as
depression,
epilepsy,
autism,
rare
We
describe
several
clinical
target
could
be
used
treat
concluded
there
few
improve
pathology
diseases
by
acting
ions.
Although
a
novel
ion-channel-specific
modulators
discovered,
meaningful
therapies
largely
not
yet
realized.
lack
target-specific
drugs,
requirement
cross
blood–brain
barrier,
exact
underlying
mechanisms
all
need
further
attention.
This
review
aims
explain
urgent
problems
research
progress
comprehensive
aiming
arouse
community’s
interest
development
channel-targeting
identification
therapeutic
targets
increase
cure
rate
reduce
adverse
reactions
other
systems.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(5), P. 1935 - 1935
Published: Feb. 24, 2025
The
role
of
amyloid
beta
peptide
(Aβ)
in
memory
regulation
has
been
a
subject
substantial
interest
and
debate
neuroscience,
because
both
physiological
clinical
issues.
Understanding
the
dual
nature
Aβ
is
crucial
for
developing
effective
treatments
Alzheimer's
disease
(AD).
Moreover,
accurate
detection
quantification
methods
isoforms
have
tested
diagnostic
purposes
therapeutic
interventions.
This
review
provides
insight
into
current
knowledge
about
vivo
vitro
by
fluid
tests
brain
imaging
(PET),
which
allow
preclinical
recognition
disease.
Currently,
priority
development
new
therapies
given
to
potential
changes
progression
In
light
increasing
amounts
data,
this
was
focused
on
employment
Frontiers in Aging Neuroscience,
Journal Year:
2025,
Volume and Issue:
17
Published: March 19, 2025
The
global
extension
of
human
lifespan
has
intensified
the
focus
on
aging,
yet
its
underlying
mechanisms
remain
inadequately
understood.
article
highlights
aspects
genetic
susceptibility
to
impaired
brain
bioenergetics,
trends
in
age-related
gene
expression
related
neuroinflammation
and
senescence,
impact
stem
cell
exhaustion
quiescence
accelerated
aging.
We
also
review
accumulation
senescent
cells,
mitochondrial
dysfunction,
metabolic
disturbances
as
central
pathological
processes
emphasizing
how
these
factors
contribute
inflammation
disrupt
cellular
competition
defining
aging
trajectory.
Furthermore,
we
discuss
emerging
therapeutic
strategies
future
potential
integrating
advanced
technologies
refine
assessments.
combination
several
methods
including
analysis,
neuroimaging
techniques,
cognitive
tests
digital
twins,
offer
a
novel
approach
by
simulating
monitoring
individual
health
trajectories,
thereby
providing
more
accurate
personalized
insights.
Conclusively,
estimation
trajectories
is
crucial
for
understanding
managing
processes,
potentially
transforming
preventive
improve
outcomes
populations.
Neural Regeneration Research,
Journal Year:
2024,
Volume and Issue:
20(5), P. 1258 - 1276
Published: June 3, 2024
The
central
nervous
system,
information
integration
center
of
the
body,
is
mainly
composed
neurons
and
glial
cells.
neuron
one
most
basic
important
structural
functional
units
with
sensory
stimulation
excitation
conduction
functions.
Astrocytes
microglia
belong
to
cell
family,
which
main
source
cytokines
represents
defense
system
system.
Nerve
cells
undergo
neurotransmission
or
gliotransmission,
regulates
neuronal
activity
via
ion
channels,
receptors,
transporters
expressed
on
nerve
membranes.
Ion
large
transmembrane
proteins,
play
crucial
roles
in
maintaining
homeostasis.
These
channels
are
also
for
control
membrane
potential
secretion
neurotransmitters.
A
variety
cellular
functions
life
activities,
including
regulation
generation
excitation,
occurrence
receptor
potential,
heart
pulsation,
smooth
muscle
peristalsis,
skeletal
contraction,
hormone
secretion,
closely
related
associated
passive
transport.
Two
types
potassium
calcium
various
neurological
disorders,
Alzheimer’s
disease,
Parkinson’s
epilepsy.
Accordingly,
drugs
that
can
affect
these
have
been
explored
deeply
provide
new
directions
treatment
disorders.
In
this
review,
we
focus
different
their
involvement
disorders
such
as
depression,
epilepsy,
autism,
rare
We
describe
several
clinical
target
could
be
used
treat
concluded
there
few
improve
pathology
diseases
by
acting
ions.
Although
a
novel
ion-channel-specific
modulators
discovered,
meaningful
therapies
largely
not
yet
realized.
lack
target-specific
drugs,
requirement
cross
blood–brain
barrier,
exact
underlying
mechanisms
all
need
further
attention.
This
review
aims
explain
urgent
problems
research
progress
comprehensive
aiming
arouse
community’s
interest
development
channel-targeting
identification
therapeutic
targets
increase
cure
rate
reduce
adverse
reactions
other
systems.
