Construction of disulfidptosis-related lncRNA signature for predicting the prognosis and immune escape in colon adenocarcinoma DOI Creative Commons
Pan Chen, Jun Yu, Qian Luo

et al.

BMC Gastroenterology, Journal Year: 2023, Volume and Issue: 23(1)

Published: Nov. 10, 2023

Colon adenocarcinoma (COAD) is one of the most frequent types cancer worldwide. Disulfidptosis has been identified as a new mode cell death recently. The goal this study was to explore possibility connection between disulfidptosis and COAD. RNA sequencing data from COAD patients were retrieved Cancer Genome Atlas (TCGA) database for investigation. R software various methods used identify disulfidptosis-related lncRNAs (DRLs) in COAD, prognostic model created based on 6 DRLs (AP003555.1, AL683813.1, SNHG7, ZEB1-AS1, AC074212.1, RPL37A-DT). demonstrated good accuracy predicting prognosis patients, according receiver operating characteristic (ROC) curve Concordance index (C-index) analyses. Gene Ontology (GO) enrichment analysis Kyoto Encyclopedia Genes Genomes (KEGG) revealed significant differences biological functions signaling pathways involved differential genes risk subgroups, including protein - DNA complex subunit organization, Hippo pathway, Wnt pathway. TIDE done groupings study, it found that high-risk group had more immune escape potential less probable react immunotherapy. Real-time quantitative pcr (qRT-PCR) relatively high expression colon lines. In summary, possible novel molecular therapy targets This be tool forecasting clinical practice, well providing insights function mechanism process.

Language: Английский

PANoptosis: bridging apoptosis, pyroptosis, and necroptosis in cancer progression and treatment DOI Creative Commons
Jie Gao,

Anying Xiong,

Jiliu Liu

et al.

Cancer Gene Therapy, Journal Year: 2024, Volume and Issue: 31(7), P. 970 - 983

Published: March 29, 2024

Abstract This comprehensive review explores the intricate mechanisms of PANoptosis and its implications in cancer. PANoptosis, a convergence apoptosis, pyroptosis, necroptosis, plays crucial role cell death immune response regulation. The study delves into molecular pathways each mechanism their crosstalk within emphasizing shared components like caspases PANoptosome complex. It highlights significant various cancers, including respiratory, digestive, genitourinary, gliomas, breast showing impact on tumorigenesis patient survival rates. We further discuss interwoven relationship between tumor microenvironment (TME), illustrating how influences behavior progression. underscores dynamic interplay tumors microenvironments, focusing roles different cells interactions with cancer cells. Moreover, presents new breakthroughs therapy, potential targeting to enhance anti-tumor immunity. outlines strategies manipulate for therapeutic purposes, such as key signaling molecules caspases, NLRP3, RIPK1, RIPK3. novel treatments immunogenic PANoptosis-initiated therapies nanoparticle-based is also explored.

Language: Английский

Citations

33
Rnd3 protects against doxorubicin-induced cardiotoxicity through inhibition of PANoptosis in a Rock1/Drp1/mitochondrial fission-dependent manner DOI Creative Commons
Ge Wen, Xiaohua Zhang,

Jie Lin

et al.

Cell Death and Disease, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 4, 2025

Abstract Doxorubicin, a representative drug of the anthracycline class, is widely used in cancer treatment. However, Doxorubicin-induced cardiotoxicity (DIC) presents significant challenge its clinical application. Mitochondrial dysfunction plays central role DIC, primarily through disrupting mitochondrial dynamics. This study aimed to investigate impact Rnd3 (a Rho family GTPase 3) on with focus Cardiomyocyte-specific transgenic mice (Rnd3-Tg) and LSP/LSP (N-Tg) were established for vivo experiments, adenoviruses harboring (Ad-Rnd3) or negative control (Ad-Control) injected myocardium vitro experiments. The DIC model was using wild-type, N-Tg, Rnd3-Tg mice, subsequent intraperitoneal injection Dox 4 weeks. molecular mechanism explored RNA sequencing, immunofluorescence staining, co-immunoprecipitation assay, protein-protein docking. administration induced injury cardiac dysfunction, which ameliorated by overexpression. Further, augmentation expression mitigated fragmentation mediated dynamin-related protein 1 (Drp1), thereby ameliorating PANoptosis (pyroptosis, apoptosis, necroptosis) response Dox. Mechanically, interaction between Rho-associated kinase (Rock1) may impede Rock1-induced Drp1 phosphorylation at Ser616, thus inhibiting fission dysfunction. Interestingly, Rock1 knockdown nullified effects cardiomyocytes PANoptosis, as well Dox-induced remodeling elicited Rnd3. enhances resilience against stabilizing dynamics reducing PANoptosis. Our findings suggest that Rnd3/Rock1/Drp1 signaling pathway represents novel target mitigating modulating could be strategic approach safeguarding function patients undergoing

Language: Английский

Citations

2
Current evidence and therapeutic implication of PANoptosis in cancer DOI Creative Commons
Dickson Kofi Wiredu Ocansey, Fei Qian,

Peipei Cai

et al.

Theranostics, Journal Year: 2023, Volume and Issue: 14(2), P. 640 - 661

Published: Dec. 26, 2023

Regulated cell death (RCD) is considered a critical pathway in cancer therapy, contributing to eliminating cells and influencing treatment outcomes. The application of RCD marked by its potential targeted therapy immunotherapy. As type RCD, PANoptosis has emerged as unique form programmed (PCD) characterized features pyroptosis, apoptosis, necroptosis but cannot be fully explained any these pathways alone. It regulated multi-protein complex called the PANoptosome. relatively new concept first described 2019, been shown play role many diseases, including cancer, infection, inflammation. This study reviews PCD particularly emergence implication developing therapeutic strategies for cancer. Studies have that characterization patterns can predict survival response immunotherapy chemotherapy, highlighting used target treatment. also plays limiting spread cells. allows elimination multiple address various challenges treatment, drug resistance immune evasion. Moreover, active investigation mechanisms agents induce likely yield effective treatments improve patient Research on still ongoing, it rapidly evolving field with lead

Language: Английский

Citations

33
Induction Mechanism of Ferroptosis, Necroptosis, and Pyroptosis: A Novel Therapeutic Target in Nervous System Diseases DOI Open Access
Lu Tang, Sitong Liu, Shiwei Li

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(12), P. 10127 - 10127

Published: June 14, 2023

In recent years, three emerging cell deaths, ferroptosis, necroptosis and pyroptosis, have gradually attracted everyone’s attention, they also play an important role in the occurrence development of various diseases. Ferroptosis is idiographic iron-dependent form regulated death with hallmark accumulation intracellular reactive oxygen species (ROS). Necroptosis a necrotic mediated by receptor-interacting protein kinase 1(RIPK1) 3RIPK3. Pyroptosis, known as inflammatory necrosis, programmed necrosis Gasdermin D (GSDMD). It manifested continuous swelling cells until membrane ruptures, resulting release contents activation strong response. Neurological disorders remain clinical challenge patients do not respond well to conventional treatments. Nerve can aggravate neurological This article reviews specific mechanisms these types their relationship diseases evidence for diseases; understanding pathways helpful treatment

Language: Английский

Citations

30
The emerging role of PANoptosis in cancer treatment DOI Open Access

Yongai Xiong

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 168, P. 115696 - 115696

Published: Oct. 12, 2023

Programmed cell death (PCD) is a key mechanism for the study of anticancer drugs and has significant impact on development management cancer. A growing amount data indicates that different kinds PCD, particularly pyroptosis, apoptosis, necroptosis, interact closely. Recent research revealed existence distinct inflammatory PCD modality known as PANoptosis, which controlled by complex PANoptosome complexes built combining elements from pathways. No single route sufficient to explain all physiologic effects seen in PANoptosis. Numerous studies have demonstrated PANoptosis can successfully stop cancer cells growing, proliferating, developing drug resistance. As result, it changed focus targeted therapy. In this review, we outlined molecular processes activation modulation well mechanisms innate immune death. order provide theoretical foundation targeting an anti-cancer target, also highlight PANoptosomes discovered date give overview implications treatment.

Language: Английский

Citations

26
Ursodeoxycholic acid alleviates sepsis-induced lung injury by blocking PANoptosis via STING pathway DOI

Yu-qiong He,

Jiuling Deng,

Cancan Zhou

et al.

International Immunopharmacology, Journal Year: 2023, Volume and Issue: 125, P. 111161 - 111161

Published: Nov. 9, 2023

Language: Английский

Citations

25
Membrane-anchoring clickable Iridium(III) nanosonosensitizer in situ evokes PANoptosis for augmented tumor sono-immunotherapy DOI
Xiaoyu Xu,

Shayibai Shabiti,

Xu Zhang

et al.

Nano Today, Journal Year: 2024, Volume and Issue: 56, P. 102270 - 102270

Published: April 15, 2024

Language: Английский

Citations

14
PANoptosis subtypes predict prognosis and immune efficacy in gastric cancer DOI
Zitao Liu, Liang Sun, Xingyu Peng

et al.

APOPTOSIS, Journal Year: 2024, Volume and Issue: 29(5-6), P. 799 - 815

Published: Feb. 12, 2024

Language: Английский

Citations

13
Neurotoxic β-amyloid oligomers cause mitochondrial dysfunction—the trigger for PANoptosis in neurons DOI Creative Commons
Xiangyuan Meng, Qi Song, Zinan Liu

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: May 14, 2024

As the global population ages, incidence of elderly patients with dementia, represented by Alzheimer's disease (AD), will continue to increase. Previous studies have suggested that β-amyloid protein (Aβ) deposition is a key factor leading AD. However, clinical efficacy treating AD anti-Aβ antibodies not satisfactory, suggesting Aβ amyloidosis may be pathological change rather than Identification causes and development corresponding prevention treatment strategies an important goal current research. Following discovery soluble oligomeric forms (AβO) in 1998, scientists began focus on neurotoxicity AβOs. endogenous neurotoxin, active growth AβOs can lead neuronal death, which believed occur before plaque formation, are factors PANoptosis, newly proposed concept cell death includes known modes pyroptosis, apoptosis, necroptosis, form regulated PANoptosome complex. Neuronal survival depends proper mitochondrial function. Under conditions AβO interference, dysfunction occurs, releasing lethal contents as potential upstream effectors PANoptosome. Considering critical role neurons cognitive function well regulatory survival, investigation mechanisms PANoptosis crucial. This review describes disruption elucidates how activate causing during AD, providing guidance for targeted strategies.

Language: Английский

Citations

12
Exploration of the mode of death and potential death mechanisms of nucleus pulposus cells DOI

Daqian Zhou,

Yongliang Mei,

Chao Song

et al.

European Journal of Clinical Investigation, Journal Year: 2024, Volume and Issue: 54(9)

Published: April 17, 2024

Intervertebral disc degeneration (IVDD) is a common chronic orthopaedic disease in orthopaedics that imposes heavy economic burden on people and society. Although it well established IVDD associated with genetic susceptibility, ageing obesity, its pathogenesis remains incompletely understood. Previously, was thought to occur because of excessive mechanical loading leading destruction nucleus pulposus cells (NPCs), but studies have shown much more complex process inflammation, metabolic factors NPCs death can involve all parts the disc, characterized by causing extracellular matrix (ECM) degradation. The damage pattern like some programmed cell death, suggesting death. apoptosis pyroptosis been studied IVDD, intervertebral still not be fully elucidated using only traditional modalities. With increasing research, new modes PANoptosis, ferroptosis senescence found closely related degeneration. Among these, PANoptosis combines essential elements pyroptosis, necroptosis form highly coordinated dynamically balanced inflammatory process. Furthermore, we believe may also crosstalk senescence. Therefore, review progress research multiple deaths provide guidance for clinical treatment.

Language: Английский

Citations

11