Digital Spatial Profiling identifies phospho-JNK as a biomarker for early risk stratification of aggressive prostate cancer DOI Open Access
Samaneh Eickelschulte,

Adam Kaczorowski,

Florian Janke

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 22, 2024

Abstract Background Prostate cancer (PCa) is a highly heterogeneous disease, with cases ranging from indolent to aggressive forms. Ongoing research focuses on identifying new biomarkers improve early risk stratification in PCa, addressing current limitations accurately evaluate disease progression. A promising approach aid PCa digital spatial profiling (DSP) of tissue. Methods total 94 regions interest 38 patients at first diagnosis were analyzed for the expression 44 proteins, including components PI3K-AKT, MAPK, and cell death signaling pathways as well immune markers. An additional validation cohort consisting 154 long-term follow-up data was using immunohistochemistry (IHC) assess consistency identified across larger sample set. Results DSP proliferation marker Ki-67 phospho-c-Jun N-terminal protein kinase (p-JNK), member MAPK pathway, significantly upregulated proteins (Gleason scores 4 5) compared score 3). The upregulation p-JNK confirmed through IHC. High associated shorter time biochemical recurrence (log-rank, p=0.1). Conclusion Our results indicate that may contribute progression serve an biomarker stratification. Identifying this could be crucial advancing management critical unmet need more targeted therapies treatment PCa. Further studies are recommended role

Language: Английский

Cellular Aging and Senescence in Cancer: A Holistic Review of Cellular Fate Determinants DOI Creative Commons
Muhammad Tufail, Yuqi Huang,

Jia-Ju Hu

et al.

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2024

This comprehensive review navigates the complex relationship between cellular aging, senescence, and cancer, unraveling determinants of fate. Beginning with an overview aging's significance in explores processes, changes, molecular pathways influencing senescence. The senescence as a dual mechanism acting suppressor contributor, focusing on its impact therapy response. highlights opportunities for cancer therapies that target further examines senescence-associated secretory phenotype strategies to modulate aging influence tumor behavior. Additionally, mechanisms escape cells, emphasizing their prognosis resistance therapy. article addresses current advances, unexplored aspects, future perspectives understanding cancer.

Language: Английский

Citations

4
Preoperative MRI-based predictive model for biochemical recurrence following radical prostatectomy DOI
Qianyu Peng, Ling Xu,

Daming zhang

et al.

Abdominal Radiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Language: Английский

Citations

0
Molecular Signatures of Cellular Senescence in Cancer: A Critical Review of Prognostic Implications and Therapeutic Opportunities DOI

Debora C Santos-Sousa,

Suzan Gonçalves Rosa, Eduardo Cremonese Filippi–Chiela

et al.

Mechanisms of Ageing and Development, Journal Year: 2025, Volume and Issue: unknown, P. 112052 - 112052

Published: March 1, 2025

Language: Английский

Citations

0
Novel biomarkers and drug correlations of non-canonical WNT signaling in prostate and breast cancer DOI Creative Commons
Yongming Huang,

Meiyin Fan,

Yushuai Liu

et al.

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Sept. 30, 2024

Language: Английский

Citations

0
Digital Spatial Profiling identifies phospho-JNK as a biomarker for early risk stratification of aggressive prostate cancer DOI Open Access
Samaneh Eickelschulte,

Adam Kaczorowski,

Florian Janke

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 22, 2024

Abstract Background Prostate cancer (PCa) is a highly heterogeneous disease, with cases ranging from indolent to aggressive forms. Ongoing research focuses on identifying new biomarkers improve early risk stratification in PCa, addressing current limitations accurately evaluate disease progression. A promising approach aid PCa digital spatial profiling (DSP) of tissue. Methods total 94 regions interest 38 patients at first diagnosis were analyzed for the expression 44 proteins, including components PI3K-AKT, MAPK, and cell death signaling pathways as well immune markers. An additional validation cohort consisting 154 long-term follow-up data was using immunohistochemistry (IHC) assess consistency identified across larger sample set. Results DSP proliferation marker Ki-67 phospho-c-Jun N-terminal protein kinase (p-JNK), member MAPK pathway, significantly upregulated proteins (Gleason scores 4 5) compared score 3). The upregulation p-JNK confirmed through IHC. High associated shorter time biochemical recurrence (log-rank, p=0.1). Conclusion Our results indicate that may contribute progression serve an biomarker stratification. Identifying this could be crucial advancing management critical unmet need more targeted therapies treatment PCa. Further studies are recommended role

Language: Английский

Citations

0