Piezo1 mediates abnormal type 2 immune response to aggravate ischemia–reperfusion acute lung injury which by regulating alveolar macrophages derived IL-33: A hypothesis DOI

Xiwang Liu,

Xueke Wang,

Pan YiHang

et al.

Medical Hypotheses, Journal Year: 2023, Volume and Issue: 183, P. 111254 - 111254

Published: Dec. 25, 2023

Language: Английский

Microglial Piezo1 mechanosensitive channel as a therapeutic target in Alzheimer’s disease DOI Creative Commons

Erol D. Ikiz,

Erin R. Hascup, Chilman Bae

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: June 18, 2024

Microglia are the resident macrophages of central nervous system (CNS) that control brain development, maintain neural environments, respond to injuries, and regulate neuroinflammation. Despite their significant impact on various physiological pathological processes across mammalian biology, there remains a notable gap in our understanding how microglia perceive transmit mechanical signals both normal diseased states. Recent studies have revealed possess ability detect changes properties environment, such as alterations stiffness or pressure. These may occur during aging, conditions trauma neurodegenerative diseases. This review will discuss microglial Piezo1 mechanosensitive channels potential therapeutic targets for Alzheimer’s disease (AD). The structure, function, modulation be discussed, well its role facilitating clearance misfolded amyloid-β (Aβ) proteins implicated pathology AD.

Language: Английский

Citations

3
Pleiotropic physiological functions of Piezo1 in human body and its effect on malignant behavior of tumors DOI Creative Commons
Yihan Zhang,

Wen Zou,

Wenlei Dou

et al.

Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15

Published: April 16, 2024

Mechanosensitive ion channel protein 1 (Piezo1) is a large homotrimeric membrane protein. Piezo1 has various effects and plays an important irreplaceable role in the maintenance of human life activities homeostasis internal environment. In addition, recent studies have shown that vital tumorigenesis, progression, malignancy clinical prognosis. involved regulating malignant behaviors variety tumors, including cellular metabolic reprogramming, unlimited proliferation, inhibition apoptosis, stemness, angiogenesis, invasion metastasis. Moreover, regulates tumor progression by affecting recruitment, activation, differentiation multiple immune cells. Therefore, excellent potential as anti-tumor target. The article reviews diverse physiological functions body its major pathways during disease development, describes detail specific mechanisms which affects behavior tumors progress new target for therapy, providing perspectives exploring more on application therapy.

Language: Английский

Citations

2
The Molecular Mechanism of Macrophages in Response to Mechanical Stress DOI

Yuntong Su,

Xing Yin

Annals of Biomedical Engineering, Journal Year: 2024, Volume and Issue: 53(2), P. 318 - 330

Published: Oct. 1, 2024

Language: Английский

Citations

2
Ion channels in macrophages: Implications for disease progression DOI
Li Xu, Yuzhe Du,

Chunlei Yu

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 144, P. 113628 - 113628

Published: Nov. 19, 2024

Language: Английский

Citations

1
Increased expression levels of PIEZO1 in visceral adipose tissue in obesity and type 2 diabetes are triggered by mechanical forces and are associated with inflammation DOI Creative Commons
Victoria Catalán, Javier Gómez‐Ambrosi, Beatriz Ramírez

et al.

Molecular Medicine, Journal Year: 2024, Volume and Issue: 30(1)

Published: Dec. 20, 2024

Language: Английский

Citations

1
Shaping the Immune Landscape: Multidimensional Environmental Stimuli Refine Macrophage Polarization and Foster Revolutionary Approaches in Tissue Regeneration DOI

Jing-Dong Xue,

Jing Gao, Chao Feng

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0
Research progress on the immunological functions of Piezo1 a receptor molecule that responds to mechanical force DOI Creative Commons
Hao Xing,

Huan Liu,

Zhengqi Chang

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 139, P. 112684 - 112684

Published: July 14, 2024

The human immune system is capable of defending against, monitoring, and self-stabilizing various cells. Differentiation, proliferation, development these cells are regulated by biochemical signals. Moreover, biophysical signals, such as mechanical forces, have been found to affect cell function, thus introducing a new area immunological research. Piezo1, mechanically sensitive ion channel, was awarded the Nobel Prize for Physiology Medicine in 2021. This channel present on surface many cells, when stimulated force, it controls calcium (Ca

Language: Английский

Citations

0
Functional Role of Piezo1 in the Human Eosinophil Cell Line AML14.3D10: Implications for the Immune and Sensory Nervous Systems DOI Creative Commons
Sung-Min Hwang, Jimin Song,

Jung Ju Choi

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(9), P. 1157 - 1157

Published: Sept. 14, 2024

Mechanosensitive ion channels, particularly Piezo are widely expressed in various tissues. However, their role immune cells remains underexplored. Therefore, this study aimed to investigate the functional of Piezo1 human eosinophil cell line AML14.3D10. We detected

Language: Английский

Citations

0
The Dual Roles of Lamin A/C in Macrophage Mechanotransduction DOI Creative Commons
Yao Wang, Sabine Ruf, Lei Wang

et al.

Cell Proliferation, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 22, 2024

Cellular mechanotransduction is a complex physiological process that integrates alterations in the external environment with cellular behaviours. In recent years, role of nucleus has gathered increased attention. Our research investigated involvement lamin A/C, component nuclear envelope, macrophages under compressive force. We discovered hydrostatic force induces heterochromatin formation, decreases SUN1/SUN2 levels, and transiently downregulates A/C. Notably, downregulated A/C permeability to yes-associated protein 1 (YAP1), thereby amplifying certain effects force, such as inflammation induction proliferation inhibition. Additionally, deficiency detached linker nucleoskeleton cytoskeleton (LINC) from consequently reducing force-induced DNA damage IRF4 expression. summary, exerted dual on macrophage responses mechanical compression, promoting outcomes while inhibiting others. It operated through two distinct mechanisms: enhancing impairing intracellular mechanotransmission. The results this study support understanding mechanisms may assist identifying potential therapeutic targets for mechanotransduction-related diseases.

Language: Английский

Citations

0
Piezo1 mediates abnormal type 2 immune response to aggravate ischemia–reperfusion acute lung injury which by regulating alveolar macrophages derived IL-33: A hypothesis DOI

Xiwang Liu,

Xueke Wang,

Pan YiHang

et al.

Medical Hypotheses, Journal Year: 2023, Volume and Issue: 183, P. 111254 - 111254

Published: Dec. 25, 2023

Language: Английский

Citations

0