Preparation of Environmentally Responsive PDA&DOX@LAC Live Drug Carrier for synergistic tumor therapy DOI Creative Commons
Lu Liu, Xuefen Zhao

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: May 7, 2024

Abstract The development of intelligent, environmentally responsive, and biocompatible photothermal system holds significant importance for the combined therapy tumors. In this study, inspired by lactobacillus, we prepared a biomimetic nanoplatform, PDA&DOX@LAC, tumor photothermal-chemotherapy integrating chemotherapeutic drug doxorubicin (DOX) with dopamine through oxidative polymerization to form polydopamine on surface LAC. PDA&DOX@LAC nanoplatform not only achieves precise controlled release DOX based slightly acidic microenvironment tissues, but also exhibits enzyme-like properties alleviate hypoxia. Under near-infrared light irradiation, it effectively induces ablation cells, enhances cellular uptake increasing temperature, thus efficiently inhibits cell growth. Moreover, in vivo experiments further confirmed that cells apoptosis, releases tumor-associated antigens, is engulfed dendritic activating cytotoxic T lymphocytes, thereby suppressing growth prolonging survival period 4T1 tumor-bearing mice. Therefore, immense potential in targeting therapy, providing valuable insights theoretical foundations novel treatment strategies endogenous substances within body.

Language: Английский

Beyond DNA sensing: expanding the role of cGAS/STING in immunity and diseases DOI Creative Commons
Jin Kyung Seok,

Minhyuk Kim,

Han Chang Kang

et al.

Archives of Pharmacal Research, Journal Year: 2023, Volume and Issue: 46(6), P. 500 - 534

Published: June 1, 2023

Abstract Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) is a DNA sensor that elicits robust type I interferon response by recognizing ubiquitous danger-associated molecules. The cGAS/stimulator of genes (cGAS/STING) activated endogenous DNA, including released from mitochondria and extranuclear chromatin, as well exogenous derived pathogenic microorganisms. cGAS/STING positioned key axis autoimmunity, the inflammatory response, cancer progression, suggesting signaling pathway represents an efficient therapeutic target. Based on accumulated evidence, we present insights into prevention treatment cGAS/STING-related chronic immune diseases. This review presents current state clinical nonclinical development modulators targeting cGAS/STING, providing useful information design strategies.

Language: Английский

Citations

18
cGLRs Join Their Cousins of Pattern Recognition Receptor Family to Regulate Immune Homeostasis DOI Open Access
Vijay Kumar, John H. Stewart

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1828 - 1828

Published: Feb. 2, 2024

Pattern recognition receptors (PRRs) recognize danger signals such as PAMPs/MAMPs and DAMPs to initiate a protective immune response. TLRs, NLRs, CLRs, RLRs are well-characterized PRRs of the host system. cGLRs have been recently identified PRRs. In humans, cGAS/STING signaling pathway is part cGLRs. cGAS recognizes cytosolic dsDNA PAMP or DAMP STING-dependent response comprising type 1 IFN release, NF-κB activation, autophagy, cellular senescence. The present article discusses emergence critical how they regulate responses. We examined role signaling, well-studied cGLR system, in activation following sections discuss dysregulation disease cross-talk with other maintains homeostasis. This understanding will lead design better vaccines immunotherapeutics for various diseases, including infections, autoimmunity, cancers.

Language: Английский

Citations

8
Biomimetic Dual-Target Theranostic Nanovaccine Enables Magnetic Resonance Imaging and Chemo/Chemodynamic/Immune Therapy of Glioma DOI

Tianyu Huang,

Yunqi Guo, Zhiqiang Wang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(21), P. 27187 - 27201

Published: May 15, 2024

Development of theranostic nanomedicines to tackle glioma remains be challenging. Here, we present an advanced blood–brain barrier (BBB)-crossing nanovaccine based on cancer cell membrane-camouflaged poly(N-vinylcaprolactam) (PVCL) nanogels (NGs) incorporated with MnO2 and doxorubicin (DOX). We show that the disulfide bond-cross-linked redox-responsive PVCL NGs can functionalized dermorphin imiquimod R837 through membrane functionalization. The formed having a size 220 nm are stable, deplete glutathione, responsively release both Mn2+ DOX under simulated tumor microenvironment exert chemo/chemodynamic therapy mediated by Mn2+, respectively. combined induces immunogenic death maturate dendritic cells (DCs) activate tumor-killing T cells. Further, composed membranes as antigens, adjuvant abilities DC maturation macrophages M1 repolarization, Mn2+-mediated stimulator interferon gene activation effectively act targets immune With dermorphin-mediated BBB crossing, membrane-mediated homologous targeting, Mn2+-facilitated magnetic resonance (MR) imaging property, designed NG-based enables MR combination chemo-, chemodynamic-, imnune orthotopic significantly decreased recurrence rate.

Language: Английский

Citations

7
Green synthesis of MnO2 NPs using Arabic gum: assessing its potential antiviral activity against influenza A/H1N1 DOI Creative Commons
Neda Baghban, Safieh Momeni, Emad Behboudi

et al.

Virology Journal, Journal Year: 2024, Volume and Issue: 21(1)

Published: Feb. 23, 2024

Abstract Background The antiviral properties of metal nanoparticles against various viruses, including those resistant to drugs, are currently a subject intensive research. Recently, the green synthesis and their anti-viral function have attracted lot attention. Previous studies shown promising results in use Arabic gum for with strong properties. In this study we aimed investigate effects MnO 2 (MnO -NPs) synthesized using gum, particularly influenza virus. Methods was used as natural polymer extract synthesize -NPs chemistry approach. were characterized SEM TEM. To evaluate virus titration, cytotoxicity, activity, TCID50, MTT, Hemagglutination assay (HA) performed, respectively. Molecular docking also performed potential activity molecular carried out AutoDock Vina software followed by an analysis VMD interaction between hemagglutinin protein. Results Simultaneous combination treatment green-synthesized resulted 3.5 log HA decrement 69.7% cellular protection, which demonstrated most significant difference protection compared control group ( p -value < 0.01). showed that binding affinities − 3.3 5.8 kcal/mole relating target beta-D-galactopyranuronic acid, Conclusion indicated had virus, highlighting effective inhibition respiratory infections.

Language: Английский

Citations

4
Application of nanoparticles with activating STING pathway function in tumor synergistic therapy DOI
Yi Yang,

Yaning Fang,

Xin‐Yu Du

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 148, P. 114013 - 114013

Published: Jan. 18, 2025

Language: Английский

Citations

0
Nanocarrier-mediated modulation of cGAS-STING signaling pathway to disrupt tumor microenvironment DOI
Sai Kiran S. S. Pindiprolu,

Madhu Tanya Singh,

Magham Sai Varshini

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Language: Английский

Citations

0
Mechanisms and Applications of Manganese-Based Nanomaterials in Tumor Diagnosis and Therapy DOI Creative Commons
Xiaowen Ma, Chuan He, Yang Wang

et al.

Biomaterials Research, Journal Year: 2025, Volume and Issue: 29

Published: Jan. 1, 2025

Tumors are the second most common cause of mortality globally, ranking just below heart disease. With continuous advances in diagnostic technology and treatment approaches, survival rates some cancers have increased. Nevertheless, due to complexity mechanisms underlying tumors, cancer remains a serious public health issue that threatens population globally. Manganese (Mn) is an essential trace element for human body. Its regulatory role tumor biology has received much attention recent years. Developments nanotechnology led emergence Mn-based nanoparticles great potential use diagnosis cancers. nanomaterials can be integrated with conventional techniques, including chemotherapy, radiation therapy, gene augment their therapeutic effectiveness. Further, play synergistic emerging strategies such as immunotherapy, photothermal photodynamic electromagnetic hyperthermia, sonodynamic chemodynamic intervention therapy. Moreover, enhance both precision diagnostics capability combined treatment. This article examines roles associated Mn field physiology biology, focus on application prospects

Language: Английский

Citations

0
Multidimensional applications of prussian blue-based nanoparticles in cancer immunotherapy DOI Creative Commons
Jiayi Zhang, Fang Wang, Zhaogang Sun

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 3, 2025

Abstract Immunotherapy holds notable progress in the treatment of cancer. However, clinical therapeutic effect remains a significant challenge due to immune-related side effects, poor immunogenicity, and immunosuppressive microenvironment. Nanoparticles have emerged as revolutionary tool surmount these obstacles amplify potency immunotherapeutic agents. Prussian blue nanoparticles (PBNPs) exhibit multi-dimensional immune function cancer immunotherapy, including acting nanocarrier deliver agents, photothermal agent improve efficacy immunotherapy through therapy, nanozyme regulate tumor microenvironment, an iron donor induce events related ferroptosis tumor-associated macrophages polarization. This review focuses on advances applications PBNPs immunotherapy. First, biomedical functions are introduced. Then, based PBNPs, we systematically reviewed multidimensional application Finally, challenges future developments PBNPs-based highlighted. Graphical abstract

Language: Английский

Citations

0
cGAS-mediated Antibacterial Immunotherapy Against Tuberculosis by Macrophage-Targeted Manganese Dioxide Nanoagonist DOI

Kangsheng Liao,

Ruihong Chen, Jinwei Zhang

et al.

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
STING-Activating Layered Double Hydroxide Nano-adjuvants for Enhanced Cancer Immunotherapy DOI
Liwei Jia, Qin Yang, Xin Li

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123294 - 123294

Published: March 1, 2025

Language: Английский

Citations

0