From silent partners to potential therapeutic targets: macrophages in colorectal cancer DOI Creative Commons
Hayat Khizar, Kamran Ali, Jianwei Wang

et al.

Cancer Immunology Immunotherapy, Journal Year: 2025, Volume and Issue: 74(4)

Published: Feb. 25, 2025

Cancer cells grow and survive in the tumor microenvironment, which is a complicated process. As key part of how colorectal cancer (CRC) progresses, tumor-associated macrophages (TAMs) exhibit double role. Through angiogenesis, this TAM can promote growth cancers. Although being able to modify adjust immune great advantage, these also anti-cancer properties including direct killing cells, presenting antigens, aiding T cell-mediated responses. The delicate regulatory mechanisms between system tumors are composed complex network pathways regulated by several factors hypoxia, metabolic reprogramming, cytokine/chemokine signaling, cell interactions. Decoding figuring out systems become significant building targeted treatment programs. Targeting TAMs CRC involves disrupting chemokine signaling or adhesion molecules, reprogramming them an anti-tumor phenotype using TLR agonists, CD40 modulation, selectively removing subsets that growth. Multi-drug resistance, absence accurate biomarker, drug non-specificity major problems. Combining macrophage-targeted therapies with chemotherapy immunotherapy may revolutionize treatment. Macrophage studies will advance new technology multi-omics methodologies help us understand build specific efficient treatments.

Language: Английский

Nanotherapeutic approaches for transdermal drug delivery systems and their biomedical applications DOI
Shahid Khan, Muneeb Ullah, Sumbul Saeed

et al.

European Polymer Journal, Journal Year: 2024, Volume and Issue: 207, P. 112819 - 112819

Published: Feb. 6, 2024

Language: Английский

Citations

17
The Role of Macrophages in Various Types of Tumors and the Possibility of Their Use as Targets for Antitumor Therapy DOI Open Access
Enar Jumaniyazova, А. V. Lokhonina, D. Sh. Dzhalilova

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(3), P. 342 - 342

Published: Jan. 21, 2025

In solid tumors, tumor-associated macrophages (TAMs) are one of the most numerous populations and play an important role in processes tumor cell invasion, metastasis, angiogenesis. Therefore, TAMs considered promising diagnostic prognostic biomarkers many attempts have been made to influence these cells as part antitumor therapy. There several key principles action on ТАМs: inhibition monocyte/macrophage transition; destruction macrophages; reprogramming macrophage phenotypes (polarization M2 M1); stimulation phagocytic activity CAR-M Despite large number studies this area, date, there no adequate approaches using therapy based alterations TAM functioning that would show high efficacy when administered a mono-regimen for treatment malignant neoplasms. Studies devoted evaluation drugs acting characterized by small sample heterogeneity patient groups; addition, such studies, chemotherapy or immunotherapy is used, which significantly complicates effectiveness agent TAMs. review, we attempted systematize evidence malignancies lung cancer, breast colorectal cervical prostate gastric head neck squamous soft tissue sarcomas.

Language: Английский

Citations

2
Unraveling the enigma of tumor-associated macrophages: challenges, innovations, and the path to therapeutic breakthroughs DOI Creative Commons
Shengwen Shao, Huilai Miao, Wenxue Ma

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 14, 2023

Tumor-associated macrophages (TAMs) are integral to the tumor microenvironment (TME), influencing cancer progression significantly. Attracted by cell signals, TAMs exhibit unparalleled adaptability, aligning with dynamic milieu. Their roles span from promoting growth and angiogenesis modulating metastasis. While substantial research has explored fundamentals of TAMs, comprehending their adaptive behavior, leveraging it for novel treatments remains challenging. This review delves into TAM polarization, metabolic shifts, complex orchestration cytokines chemokines determining functions. We highlight complexities TAM-targeted focusing on adaptability potential variability in therapeutic outcomes. Moreover, we discuss synergy integrating TAM-focused strategies established treatments, such as chemotherapy, immunotherapy. Emphasis is laid pioneering methods like reprogramming immunotherapy adoption single-cell technologies precision intervention. synthesis seeks shed light TAMs’ multifaceted cancer, pinpointing prospective pathways transformative enhancing modalities oncology.

Language: Английский

Citations

29
Targeting of TAMs: can we be more clever than cancer cells? DOI Creative Commons
Julia Kzhyshkowska, Jiaxin Shen, Irina Larionova

et al.

Cellular and Molecular Immunology, Journal Year: 2024, Volume and Issue: 21(12), P. 1376 - 1409

Published: Nov. 8, 2024

АBSTRACT: With increasing incidence and geography, cancer is one of the leading causes death, reduced quality life disability worldwide. Principal progress in development new anticancer therapies, improving efficiency immunotherapeutic tools, personification conventional therapies needs to consider cancer-specific patient-specific programming innate immunity. Intratumoral TAMs their precursors, resident macrophages monocytes, are principal regulators tumor progression therapy resistance. Our review summarizes accumulated evidence for subpopulations number biomarkers, indicating predictive value clinical parameters carcinogenesis resistance, with a focus on solid cancers non-infectious etiology. We present state-of-the-art knowledge about tumor-supporting functions at all stages highlight recently identified by single-cell spatial analytical methods, that discriminate between tumor-promoting tumor-inhibiting TAMs, where both subtypes express combination prototype M1 M2 genes. focuses novel mechanisms involved crosstalk among epigenetic, signaling, transcriptional metabolic pathways TAMs. Particular attention has been given link cell metabolism epigenetic histone lactylation, which can be responsible unlimited protumoral Finally, we explain how interfere currently used therapeutics summarize most advanced data from trials, divide into four categories: inhibition TAM survival differentiation, monocyte/TAM recruitment tumors, functional reprogramming genetic enhancement macrophages.

Language: Английский

Citations

14
The next frontier in immunotherapy: potential and challenges of CAR-macrophages DOI Creative Commons
Jing Li,

Ping Chen,

Wenxue Ma

et al.

Experimental Hematology and Oncology, Journal Year: 2024, Volume and Issue: 13(1)

Published: Aug. 5, 2024

Abstract Chimeric antigen receptor macrophage (CAR-MΦ) represents a significant advancement in immunotherapy, especially for treating solid tumors where traditional CAR-T therapies face limitations. CAR-MΦ offers promising approach to target and eradicate tumor cells by utilizing macrophages’ phagocytic antigen-presenting abilities. However, challenges such as the complex microenvironment (TME), variability expression, immune suppression limit their efficacy. This review addresses these issues, exploring mechanisms of action, optimal construct designs, interactions within TME. It also delves into ex vivo manufacturing CAR-MΦ, discussing autologous allogeneic sources importance stringent quality control. The potential synergies integrating with existing cancer like checkpoint inhibitors conventional chemotherapeutics are examined highlight possible enhanced treatment outcomes. Furthermore, regulatory pathways scrutinized alongside established protocols cells, identifying unique considerations essential clinical trials market approval. Proposed safety monitoring frameworks aim manage adverse events, cytokine release syndrome, crucial patient safety. Consolidating current research insights, this seeks refine therapeutic applications, overcome barriers, suggest future directions transition from experimental platforms standard care options.

Language: Английский

Citations

12
Combined targeting of senescent cells and senescent macrophages: A new idea for integrated treatment of lung cancer DOI
Ming Gu, Yang Liu, Wenhui Zheng

et al.

Seminars in Cancer Biology, Journal Year: 2024, Volume and Issue: 106-107, P. 43 - 57

Published: Aug. 29, 2024

Language: Английский

Citations

11
Tumor-associated macrophages: Potential therapeutic targets and diagnostic markers in cancer DOI

Junyang Song,

Tian Xiao, Mingyang Li

et al.

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 249, P. 154739 - 154739

Published: Aug. 4, 2023

Language: Английский

Citations

18
Beyond the beat: A pioneering investigation into exercise modalities for alleviating diabetic cardiomyopathy and enhancing cardiac health DOI
Ahsan Riaz Khan,

Mohammed A.H. Alnoud,

Hamid Ali

et al.

Current Problems in Cardiology, Journal Year: 2023, Volume and Issue: 49(2), P. 102222 - 102222

Published: Nov. 23, 2023

Language: Английский

Citations

17
Stimuli‐Mediated Macrophage Switching, Unraveling the Dynamics at the Nanoplatforms–Macrophage Interface DOI Creative Commons
Keya Ganguly,

Rachmi Luthfikasari,

Aayushi Randhawa

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(20)

Published: April 19, 2024

Abstract Macrophages play an essential role in immunotherapy and tissue regeneration owing to their remarkable plasticity diverse functions. Recent bioengineering developments have focused on using external physical stimuli such as electric magnetic fields, temperature, compressive stress, among others, micro/nanostructures induce macrophage polarization, thereby increasing therapeutic potential. However, it is difficult find a concise review of the interaction between stimuli, advanced micro/nanostructures, polarization. This examines present research stimuli‐induced polarization micro/nanoplatforms, emphasizing synergistic fabricated structure stimulation for regeneration. A overview advancements investigating impact including forces, fluid shear photothermal multiple stimulations macrophages within complex engineered structures, provided. The prospective implications these strategies regenerative medicine immunotherapeutic approaches are highlighted. will aid creating stimuli‐responsive platforms immunomodulation

Language: Английский

Citations

8
Immunotherapy and the ovarian cancer microenvironment: Exploring potential strategies for enhanced treatment efficacy DOI Creative Commons
Zhibin Wang, Xiu Zhang, Chao Fang

et al.

Immunology, Journal Year: 2024, Volume and Issue: 173(1), P. 14 - 32

Published: April 15, 2024

Despite progress in cancer immunotherapy, ovarian (OC) prognosis continues to be disappointing. Recent studies have shed light on how not just tumour cells, but also the complex microenvironment, contribute this unfavourable outcome of OC immunotherapy. The complexities immune microenvironment categorize as a 'cold tumour'. Nonetheless, understanding precise mechanisms through which influences effectiveness immunotherapy remains an ongoing scientific endeavour. This review primarily aims dissect inherent characteristics and behaviours diverse cells within along with exploration into its reprogramming metabolic changes. It is expected that these insights will elucidate operational dynamics lay theoretical groundwork for improving efficacy management.

Language: Английский

Citations

6