Frontiers in Cardiovascular Medicine,
Journal Year:
2024,
Volume and Issue:
11
Published: Sept. 12, 2024
Ischemic
heart
disease
refers
to
the
imbalance
between
supply
and
demand
of
myocardial
blood;
it
has
various
causes
results
in
a
class
clinical
diseases
characterized
by
ischemia
(MI).
In
recent
years,
incidence
cardiovascular
become
higher
higher,
number
patients
with
ischemic
also
increased
year
year.
Traditional
treatment
methods
include
drug
therapy
surgical
treatment,
both
which
have
limitations.
The
former
maybe
develop
risks
resistance
more
significant
side
effects,
while
latter
may
damage
blood
vessels
risk
infection.
At
this
stage,
new
cell-free
method
needs
be
explored.
Many
research
shown
that
exosomes
from
different
cell
sources
can
protect
myocardium
via
intercellular
action
methods,
such
as
promoting
angiogenesis,
inhibiting
fibrosis,
apoptosis
pyroptosis,
providing
basis
for
MI.
review,
we
briefly
introduce
formation
consequences
biology
exosomes,
then
focus
on
role
mechanism
We
discuss
pretreated
Chinese
Western
medicines
ischemia.
potential
diagnostic
markers
therapeutic
Cancer Immunology Immunotherapy,
Journal Year:
2025,
Volume and Issue:
74(5)
Published: March 15, 2025
Abstract
The
TAM
receptor
family
is
getting
more
and
attention
in
the
field
of
tumour
immunity.
Activation
receptors
not
only
aids
survival
multiplication
cells
but
also
increases
their
likelihood
invading
other
spreading.
In
addition,
activation
helps
to
inhibit
anti-tumour
immune
response,
allowing
evade
surveillance.
terms
therapeutic
strategies,
a
number
inhibitors
targeting
are
preclinical
clinical
development.
Despite
significant
progress
trials
recent
years,
challenges
remain.
This
review
delves
into
kinetic
characteristics
family,
dual
role
immunity,
transmission
process
downstream
signalling
pathways.
Based
on
this,
we
analysed
summarised
unique
strategies
combination
therapies
for
regulating
immunity
using
inhibitors.
It
elucidate
key
provides
new
perspectives
future
therapy.
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: Oct. 9, 2023
Introduction
Hypoxia
is
associated
with
unfavorable
prognoses
in
melanoma
patients,
and
the
limited
response
rates
of
patients
to
PD-1/PD-L1
blockade
could
be
attributed
immunosuppressive
tumor
microenvironment
induced
by
hypoxia.
Exercise
offers
numerous
benefits
anti-tumor
process
has
potential
alleviate
hypoxia;
however,
precise
mechanisms
through
which
it
exerts
its
effects
remain
unclear,
presence
synergistic
immunotherapy
yet
definitively
established.
Methods
We
established
a
B16F10
homograft
malignant
model
implemented
two
distinct
exercise
treatments
(low/moderate-intensity
swim)
based
on
mice’s
status.
The
specific
function
manner
exercise-induced
was
determined
RNA
sequencing
analysis
changes
microenvironment.
Furthermore,
moderate-intensity
swim
that
exhibited
superior
suppression
combined
Anti-PD-1
treatment
evaluate
vivo
efficacy
mouse
models.
Results
intervention
yielded
considerable
effect
impeding
growth
promoting
apoptosis.
Immunohistochemistry
revealed
improvements
hypoxia
down-regulation
hypoxia-related
pathways.
Cellular
immunofluorescence
ELISA
analyses
demonstrated
notable
increase
cytotoxic
T
cell
amount
decrease
regulatory
cells,
indicating
an
improvement
immune
In
comparison
monotherapy,
suppressive
combination
therapy
found
enhanced
both
hypoxic
infiltration.
Conclusion
as
modulator
improving
microenvironment,
resulting
promotion
facilitation
biologically
safe
sensitization
immunotherapy.
Frontiers in Oncology,
Journal Year:
2024,
Volume and Issue:
14
Published: May 1, 2024
Background
Fast
adaptation
of
glycolytic
and
mitochondrial
energy
pathways
to
changes
in
the
tumour
microenvironment
is
a
hallmark
cancer.
Purely
ρ
0
cells
do
not
form
primary
tumours
unless
they
acquire
healthy
mitochondria
from
their
micro-environment.
Here
we
explored
effects
severely
compromised
respiration
on
metastatic
capability
4T1
mouse
breast
cancer
cells.
Methods
cell
lines
with
different
levels
respiratory
capacity
were
generated;
Seahorse
extracellular
flux
analyser
was
used
evaluate
oxygen
consumption
rates,
fluorescent
confocal
microscopy
assess
number
SYBR
gold-stained
DNA
nucleoids,
presence
ATP5B
protein
cytoplasm
situ
nuclear
hybridization
establish
ploidy.
MinION
nanopore
RNA
sequence
analysis
compare
transcription
between
lines.
Orthotopic
injection
determine
ability
metastasize
lungs
female
Balb/c
mice.
Results
OXPHOS-deficient
ATP5B-KO3.1
did
generate
tumours.
Severely
OXPHOS
D5
generated
both
lung
metastases.
Cells
metastasis
OXPHOS-competent
OXPHOS-compromised
formed
but
no
metastases
when
re-injected
into
significantly
increased
mtDNA
content,
this
result
capacity,
which
due
decreased
transcription.
Gene
set
enrichment
suggests
that
certain
derived
downregulate
epithelial-to-mesenchymal
related
pathways.
Conclusion
In
summary,
required
for
tumorigenesis
orthotopic
model
even
very
low
are
sufficient
Frontiers in Cardiovascular Medicine,
Journal Year:
2024,
Volume and Issue:
11
Published: Sept. 12, 2024
Ischemic
heart
disease
refers
to
the
imbalance
between
supply
and
demand
of
myocardial
blood;
it
has
various
causes
results
in
a
class
clinical
diseases
characterized
by
ischemia
(MI).
In
recent
years,
incidence
cardiovascular
become
higher
higher,
number
patients
with
ischemic
also
increased
year
year.
Traditional
treatment
methods
include
drug
therapy
surgical
treatment,
both
which
have
limitations.
The
former
maybe
develop
risks
resistance
more
significant
side
effects,
while
latter
may
damage
blood
vessels
risk
infection.
At
this
stage,
new
cell-free
method
needs
be
explored.
Many
research
shown
that
exosomes
from
different
cell
sources
can
protect
myocardium
via
intercellular
action
methods,
such
as
promoting
angiogenesis,
inhibiting
fibrosis,
apoptosis
pyroptosis,
providing
basis
for
MI.
review,
we
briefly
introduce
formation
consequences
biology
exosomes,
then
focus
on
role
mechanism
We
discuss
pretreated
Chinese
Western
medicines
ischemia.
potential
diagnostic
markers
therapeutic
